Study of antimicrobial activity and atomic force microscopy imaging of the action mechanism of cashew tree gum

Campos, Débora A.; Ribeiro, Alexandra C.; Costa, Eduardo M.; Fernandes, João; Tavaria, Freni K.; Araruna, Felipe Bastos; Eiras, Carla; Eaton, Peter; Leite, José Roberto S. A.; Pintado, Manuela

doi:10.1016/j.carbpol.2012.05.034

Cited by 55 publications

(31 citation statements)

References 9 publications

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“…CG was chosen as the capping agent for the AgNPs because this polymer has been previously applied in AgNP synthesis, and showed antimicrobial activity [ 9 , 10 ]. In addition, cashew gum itself is highly non-toxic and shows mild antibacterial activity [ 10 , 17 ]. Several types of chemical modifications have previously been used to treat CG in order to improve its technological properties [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…The application of natural polymers has been important for the stabilization of the colloidal system, as well as for improved biocompatibility [ 16 ]. Due to the antimicrobial properties of cashew gum alone [ 17 ], as well as its ability to reduce silver to form nanoparticles that are coupled with high biocompatibility [ 9 , 10 ], cashew gum-capped silver nanoparticles appear to be a possibly useful antimicrobial agent with which to load gels for topical applications to wounds. No previous work has demonstrated the production and characterization of hydrogels containing such particles however.…”

Section: Introductionmentioning

confidence: 99%

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In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

Akmf

et al. 2017

IJMS

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Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

Akmf

et al. 2017

IJMS

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“…Campos et al (183) evaluated two A. occidentale starch (10 to 60 mg/mL) samples (crude and purified) against E. coli, S. aureus, Listeria innocua, P. aeruginosa, Enterococcus faecium, and Lactobacillus acidophilus strains. Both samples were able to inhibit growth, with MICs ranging from 20 to 30 mg/mL for the crude starch, and 40 to 60 mg/mL for the purified starch.…”

Section: In Vitro Studies Antibacterial Propertiesmentioning

confidence: 99%

Antioxidant, Antimicrobial, and Anticancer Effects of Anacardium Plants: An Ethnopharmacological Perspective

et al. 2020

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Anacardium plants have received increasing recognition due to its nutritional and biological properties. A number of secondary metabolites are present in its leaves, fruits, and other parts of the plant. Among the diverse Anacardium plants' bioactive effects, their antioxidant, antimicrobial, and anticancer activities comprise those that have gained more attention. Thus, the present article aims to review the Anacardium plants' biological effects. A special emphasis is also given to their pharmacological and clinical efficacy, which may trigger further studies on their therapeutic properties with clinical trials.

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“…Similar results have been observed by Quelemes et al [40] where the use of cashew gum, which is structurally similar to RAG, did not inhibit bacterial growth within the range of concentrations tested. It is known that molecular weight, charge density, and/or the distribution of the polysaccharides play an important role in their biological activity [85]. Therefore, the absence of antimicrobial activity by RAG could be attributed to the repulsion between the charge of the molecule (zeta potential −24.50 ± 0.9 mV) and the cell wall of the bacterium, where the zeta potential can range from −10 to −90 mV [86].…”

Section: Evaluation Of Rag In Secretory Diarrhea Induced By Etecmentioning

confidence: 99%

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

Araújo

Oliveira²,

Sousa

et al. 2020

Pharmaceuticals

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Anadenanthera colubrina var. cebil (Griseb.) Altschul (Fabaceae family), commonly known as the red angico tree, is a medicinal plant found throughout Brazil’s semi-arid area. In this study, a chemical analysis was performed to investigate the antidiarrheal activity and safety profile of red angico gum (RAG), a biopolymer extracted from the trunk exudate of A. colubrina. Upon FT-IR spectroscopy, RAG showed bands in the regions of 1608 cm−1, 1368 cm−1, and 1029 cm−1, which relate to the vibration of O–H water molecules, deformation vibration of C-O bands, and vibration of the polysaccharide C-O band, respectively, all of which are relevant to glycosidic bonds. The peak molar mass of RAG was 1.89 × 105 g/mol, with the zeta potential indicating electronegativity. RAG demonstrated high yield and solubility with a low degree of impurity. Pre-treatment with RAG reduced the total diarrheal stool and enteropooling. RAG also enhanced Na+/K+-ATPase activity and reduced gastrointestinal transit, and thereby inhibited intestinal smooth muscle contractions. Enzyme-Linked Immunosorbent Assay (ELISA) demonstrated that RAG can interact with GM1 receptors and can also reduce E. coli-induced diarrhea in vivo. Moreover, RAG did not induce any signs of toxicity in mice. These results suggest that RAG is a possible candidate for the treatment of diarrheal diseases.

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Study of antimicrobial activity and atomic force microscopy imaging of the action mechanism of cashew tree gum

Cited by 55 publications

References 9 publications

In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent

Antioxidant, Antimicrobial, and Anticancer Effects of Anacardium Plants: An Ethnopharmacological Perspective

Biopolymer Extracted from Anadenanthera colubrina (Red Angico Gum) Exerts Therapeutic Potential in Mice: Antidiarrheal Activity and Safety Assessment

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