Study of Antimutagenic Potential of Phytoconstituents Isolated from Terminalia arjuna in the Salmonella/Microsome Assay

Kaur, Satwinderjeet; Kumar, Subodh; Kaur, P.; Chandel, Madhu

doi:10.5099/aj100200164

Cited by 18 publications

(10 citation statements)

References 26 publications

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“…Plants like Acacia salicina [44] , Mangifera indica L . [45] ), Phellinus rimosus [46] , Terminalia arjuna [47] , Uncaria tomentosa [48] ), Heterotheca inuloides [49] , Ajuga bracteosa [50] and many more have shown effective antimutagenic properties.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense

et al. 2017

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“…In another study, phytoconstituents isolated from Terminalia arjuna suppressed the mutagenic effect of the aromatic amine, i.e., 2-aminofluorene (2-AF) (Kaur et al 2010). The observed activity was found to be a consequence of the inhibition of the metabolic activation of 2-AF to the mutagenic forms.…”

Section: Antimutagens That Inhibit the Activation Of Mutagensmentioning

confidence: 99%

Antimutagenic compounds and their possible mechanisms of action

et al. 2014

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Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described.

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“…They were reported to work through possible inhibition of L-azidoalanine and O 6 -methylguanine formation [34]. Similarly, Terminalia arjuna constituents were reported to suppress the mutagenic effect of the aromatic amine, i.e., 2-aminofluorene (2-AF) by inhibiting its metabolic activation [35].…”

Section: Inhibition Of Promutagen Bioactivationmentioning

confidence: 99%

Fruits and Vegetables as Dietary Sources of Antimutagens

Gautam¹,

Saxena²,

Kumar³

2016

J Food Chem Nanotechnol

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Mutation is the process leading to heritable changes in the genetic material of an organism and caused mainly by the external factors, including chemical and physical agents, or can also occur spontaneously due to errors in DNA replication, repair, and recombination. Agents contributing to the mutagenic burden in the environment could be from industrial sources, wide spectrum applications of biocides in the agriculture, and other contaminants. As many of these mutagenic chemicals can induce severe disorders in humans including cancer and a large spectrum of inherited diseases, it is important to detect such mutagenic agents precisely and rapidly, and also look for an approach to combat them. Natural occurring dietary antimutagens primarily from health protective foods such as fruits and vegetables could provide a mechanism to counteract the deleterious effect of these mutagens. The World Health Organization (WHO) indicates that one-third of all cancer deaths are preventable and that diet is closely linked to cancer prevention. These health protective phytochemicals particularly antimutagenic ones could provide an effective solution to these concerns. The current review deals with understanding of the mutagenic events, methods of its analysis and a brief compilation of the existing scientific findings related to the dietary sources having potential to counteract the effects of the mutagenic exposures from different sources. The review would provide an opportunity to look into the science, think about the possible future perspectives and mechanism to translate the outcome of the scientific research for benefits of the mankind.

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Study of Antimutagenic Potential of Phytoconstituents Isolated from Terminalia arjuna in the Salmonella/Microsome Assay

Cited by 18 publications

References 26 publications

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense

Antimutagenic compounds and their possible mechanisms of action

Fruits and Vegetables as Dietary Sources of Antimutagens

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