Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status

Raman, R.; Manimaran, D; Rachakatla, Praveen; Bharathi, K.; Afroz, Tameem; Sagar, Radha

doi:10.7860/jcdr/2016/17459.7718

Cited by 11 publications

(9 citation statements)

References 11 publications

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“…But in HAART-naïve HIV-infected adults, the CD4 count was significantly and inversely correlated with APTT. The finding was in agreement with a study conducted in Nigeria, Iran, and India [12, 45, 46]. The possible reason is that when CD4 count decreases there was an increase in the incidence of lupus anticoagulant and anticardiolipin antibodies.…”

Section: Discussionsupporting

confidence: 92%

“…This study was in agreement with the researches done in Karimnagar, India, and Mbarara, Uganda, which found low platelet count in HIV patients compared to HIV negatives [12, 13]. Studies conducted in Sudan, Benin city of Nigeria, and the Anambra state of Nigeria also found low platelet count in HIV-infected individuals compared to healthy controls [28–30].…”

Section: Discussionsupporting

confidence: 91%

“…The abnormalities caused by HIV infection include thrombocytopenia [11], endothelial cell dysfunction, activation of coagulation factors, and presence of anti-phospholipids antibody [12]. Both in vivo and in vitro studies showed that HIV has an ability to bind to the host cell via their receptor found on the surface of the host cells.…”

Section: Introductionmentioning

confidence: 99%

“…Such complications limit the production of most coagulation factors, natural anticoagulants, fibrinolytic factors, and hematopoietic growth hormones which may contribute for hemostatic disorders [22, 23]. Furthermore, highly active antiretroviral therapy (HAART) drugs have adverse effects and cause hepatic damage that leads to a decreased production of coagulation factors [12]. HAART drugs especially protease inhibitors cause endothelial dysfunction by their effects on the metabolism of lipid and glucose [24].…”

Section: Introductionmentioning

confidence: 99%

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Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

Seyoum

Enawgaw

Getaneh

et al. 2018

BioMed Research International

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Objective We aimed at assessing the basic coagulation parameters of HIV-infected adults at the University of Gondar Hospital antiretroviral therapy clinic. Methods A comparative cross-sectional study was conducted from February to May 2017. A total of 300 study participants, consisting of 100 HAART-naïve HIV-infected adults, 100 HIV-infected adults who were taking HAART, and 100 HIV-seronegative apparently healthy adults, were included. Basic coagulation functional assays such as PT, APTT, and INR were determined by coagulation analyzer. CD4 cells and platelet count were analyzed by FACS count and SYSMEX K-21N automated analyzer, respectively. The data were entered, cleaned, and edited using Epi Info version 7 and analyzed using SPSS version 20. Kruskal-Wallis H, Dunn-Bonferroni pairwise comparison test, and Spearman's rank-order correlation analysis were used for inferential statistics. The results were expressed by a median and presented in tables. P value < 0.05 was considered as statistically significant. Results PT, APTT, and INR were significantly higher, whereas platelet count was significantly lower in HIV-infected adults (both who were taking HAART and HAART-naïve) than HIV-seronegative adults (P < 0.001). PT and INR were significantly higher, and platelet count was significantly lower in HAART-naïve HIV-infected adults than HIV-infected adults who were taking HAART. In Spearman's rank-order correlation analysis, APTT has shown a significant negative correlation with a CD4 count in HAART-naïve HIV-infected adults. Conclusion HIV-infected adults are more likely to develop coagulation abnormality than HIV-seronegative subjects. Coagulation parameters need to be checked regularly to monitor coagulation disorders in HIV-infected adults.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

Seyoum

Enawgaw

Getaneh

et al. 2018

BioMed Research International

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“…Regarding changes related to TCD4 + cell count, we observed higher values of vWF for the male HIV reactive group with > 400 cells / mm 3 . We know that lower TCD4 + T counts (<200 cells / mm 3 ) are related to drastic changes in coagulation and disease progression [60,61,71]. In studies with younger populations, the change in vWF was associated with changes in inflammatory and coagulation markers [57,71].…”

Section: Discussionmentioning

confidence: 99%

Hemostasis in elderly patients with human immunodeficiency virus (HIV) infection—Cross-sectional study

et al. 2020

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Introduction: Aging and chronic HIV infection are clinical conditions that share the states of inflammation and hypercoagulability. The life expectancy of the world population has increased in the last decades, bringing as complications the occurrence of diseases that undergoing metabolic, bone, cardiological, vascular and neurological alterations. HIVinfected patients experience these changes early and are living longer due to the success of antiretroviral therapy. The objectives of this study was to evaluate some changes in the plasma hemostatic profile of 115 HIV-reactive elderly individuals over 60 years old in the chronic phase of infection, and compare with 88 healthy uninfected elderly individuals. Plasma determinations of D-dimers, Fibrinogen, von Willebrand Factor, Antithrombin, Prothrombin Time, Activated Partial Thromboplastin Time, and platelet count were performed. In the HIV-reactive group, these variables were analyzed according to viral load, protease inhibitor use and CD4 + T lymphocyte values. After adjusted values for age and sex, the results showed higher levels of Antithrombin (103%; 88%, p = 0.0001) and Prothrombin Time activities (92.4%; 88.2%, p = 0.019) in the HIV group compared to the control group. We observed higher values of Fibrinogen in protease inhibitor users in both the male (p = 0.043) and female (p = 0.004) groups, and in the female HIV group with detected viral load (p = 0.015). The male HIV group with a CD4 + count> 400 cells / mm 3 presented higher von Willebrand Factor values (p = 0.036). D-Dimers had higher values in the older age groups (p = 0.003; p = 0.042, respectively). Conclusion: Our results suggest that the elderly with chronic HIV infection with few comorbidities had a better hemostatic profile than negative control group, reflecting the success of treatment. Protease inhibitor use and age punctually altered this profile.

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Plasma levels of fibrinolytic and coagulation biomarkers in HIV‐infected individuals on highly active antiretroviral therapy: A case‐control study in a Northern Ghanaian population

Derigubah

Nkansah

Mensah

et al. 2023

Health Science Reports

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Background and Aim: Impaired coagulation and fibrinolysis have been implicated in thromboembolism in human immunodeficiency virus (HIV)-infected individuals. This study evaluated the plasma levels of plasminogen activator inhibitor-1 (PAI-1) and coagulation biomarkers in HIV-infected individuals on highly active antiretroviral therapy (HAART).Methods: This matched case-control study from March to December, 2020 comprised 76 participants: 38 HIV-positive individuals on HAART and 38 apparently healthy HIV-negative individuals as controls. Blood samples were collected for prothrombin time (PT), activated partial thromboplastin time (aPTT), D-dimers, PAI-1, and soluble fibrin monomer complex (SFMC) estimations. The data were analysed using SPSS version 22.0 and statistical significance was set at p < 0.05.

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Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and ART Status

Cited by 11 publications

References 11 publications

Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

Basic Coagulation Parameters among Human Immunodeficiency Virus-Infected Adults in Gondar, Northwest Ethiopia: A Comparative Cross-Sectional Study

Hemostasis in elderly patients with human immunodeficiency virus (HIV) infection—Cross-sectional study

Plasma levels of fibrinolytic and coagulation biomarkers in HIV‐infected individuals on highly active antiretroviral therapy: A case‐control study in a Northern Ghanaian population

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