Loosening of bolted joint structure is a critical failure mode mainly caused by the slippage and friction behaviours on the thread and bearing surfaces. Domestic and foreign scholars have conducted a series of studies on the loosening mechanism and anti-loosening methods of bolted joint structures; however, there are fewer summaries on the influencing factors of loosening of bolted joint structures. This paper takes the phenomenon of loosening of bolted joint structure as the research object, summarizes the research method of loosening of bolt joint structure and the influencing factors, and summarizes the influencing law of loosening of bolted joint structure in four aspects, namely, preload force, external load factors, structural factors, and operating temperature, to provide references for the design of anti-loosening of bolted joint structure.