Study of Burden in Polycystic Ovary Syndrome at Global, Regional, and National Levels from 1990 to 2019

Abstract

Increasing attention has recently been paid to the harm of polycystic ovary syndrome (PCOS) to women. However, due to the inconsistency of global clinical diagnostic standards and the differing allocation of medical resources among different regions, there is a lack of comprehensive estimation of the global incidence and disability-adjusted life years (DALYs) of PCOS. Thus, it is difficult to assess the disease burden. We extracted PCOS disease data from 1990 to 2019 from the Global Burden of Disease Study (GBD) 2019 and estimated the incidence, DALYs, and the corresponding age-standardized rates (ASRs) of PCOS, as well as the socio-demographic index (SDI) quintiles, to describe epidemiological trends at the global level, encompassing 21 regions and 204 countries and territories. Globally, the incidence and DALYs of PCOS have increased. Its ASR also shows an increasing trend. Among them, the high SDI quintile seems relatively stable, whereas other SDI quintiles are constantly rising over time. Our research has provided clues regarding the disease pattern and epidemic trend of PCOS and analyzed the possible causes of disease burden in some specific countries and territories, which may have some value in health resource allocation and health policy formulation and prevention strategies.

Global and regional trends and age-period-cohort effects in polycystic ovary syndrome burden from 1990 to 2019, with predictions to 2040

“…Although several previous studies have reviewed the burden of PCOS in multiple regions and countries (Gao et al, 2023;Liu et al, 2021;Sa ri et al, 2022), there are some shortcomings. For example, disability adjusted life years (DALYs) are reported, rather than years lived with disability (YLDs).…”

Exploring the Therapeutic Potential of Natural Products in Polycystic Ovarian Syndrome (PCOS): A Mini-Review of Lipid Profile, Blood Glucose, and Ovarian Histological Improvements

“…The prevalence of this disease was reported to be 5.6-8% in Europe [8]. According to recent studies, the prevalence of PCOS in Malaysia is 36.23%, based on the Rotterdam criteria, and 6.8%, based on the National Institute of Health (NIH) [9]. It has been shown that the cause of infertility is failure to ovulate in approximately 75% of cases [8].…”