Study of clinical and hematological profile in children with dengue fever in a teaching hospital in Telangana

Abstract

Introduction:The aim of the study was to determine the clinical and hematological profile in patients with Dengue fever. Materials and Methods: This was a prospective study done at Malla Reddy Medical College for Women, Telangana, for a period of six months. A total of 110 cases of dengue infection were studied. The patient demographics, clinical symptoms, hematological characteristics such as hemoglobin, total leucocyte count, platelet count, serological studies and abdominal ultrasound findings were noted. Results: In the present study, 85/110 (77.2%) cases were of dengue fever, 20/110 (18.1%) were dengue hemorrhagic fever (DHF) and 05/110 (4.5%) were of dengue shock syndrome (DSS). Patient age ranged from 0-12 years. Majority, 55/110 (50%) were among 6-8 years. Males were affected more than females (59% boys and 41% were girls). Moderate thrombocytopenia was seen in 54.5% of cases and raised hematocrit (>47%) was observed in 22.7% cases. Most of the cases 75 (68.1%) were noted in September and October. Conclusion: Dengue is a common viral infection which may have serious consequences especially in children. Simple haematological parameters along with serological tests and ultrasound of abdomen are helpful in the diagnosis and appropriate management of these patients. managed, may lead to rapid death, particularly in children [5,6]. Dengue is an acute febrile disease caused by a flavivirus with four known serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). The four serotypes can lead to variable clinical presentations, ranging from asymptomatic to severe forms [7].Children represent more peculiar characteristics since dengue diagnosis, and recognition of severe forms are both more difficult to find than in adults. The common signs and symptoms are fever, headache, myalgia, arthralgia, and bleeding manifestations. The exact clinical profile is necessary for the patient's management and hence, crucial for saving life [8]. Aim of the study:To study clinical and hematological profile in children with dengue fever.

A study on predictors of severe dengue in pediatric patients in a tertiary care hospital in Telangana

“…Anand et al [19] reported hepatomegaly in 57% of cases which is similar to our study but splenomegaly was seen only in children with concurrent malaria or Gram-negative infection. As per studies done by Sastry et al [20] and Sahana et al [21], more frequent association of organomegaly and fluid collection were reported in severe dengue than our study. Mishra et al [7] reported more GI bleed (76.9) in severe dengue group than ours.…”

Hematological and coagulation profile of dengue infection in age group 1 to 12 years children in a tertiary care hospital

“…Non-severe dengue includes both DF and DFW and SD includes DHF/DSS. We had included age group from 1 to 12 years and maximum numbers of cases were seen in the age group >6 years of age (51%) and the least affected age group was 1-3 years of age (21%) which was similar findings to the many other studies like 5 The mean age group in this study was 6.8. More involvement in children > 6years could be explained by the diurnal adaptation of Aedes mosquito in stored water.…”