Study of Clinical Profile and Antibiotic Response in Typhoid Fever at Faridpur Medical College Hospital

Saha, Aloke Kumar; Hassan, Kamrul; Kundu, Lakshman Chandra; Saha, Shyamal Kumar; Begum, Poly

doi:10.3329/fmcj.v12i1.33455

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Abdominal pain was present in only 10% of patients. 17 Likewise in another study pyrexia was present in all individuals followed by emesis and abdominal pain in 31% patients, findings are somewhat similar to our study 18 So it was demonstrated in the above study that the percentage of children achieving defervescence within 96 hours was greater in the ceftriaxone treated children as compared to the those who were administered ciprofloxacin 10 . Another study by Butt T et al reported similar results 19 .…”

Section: Exact Sig (1-sided)supporting

confidence: 88%

Clinical Efficacy Of Ceftriaxone Versus Ciprofloxacin In Paediatric Enteric Fever

Farhat¹,

Shaukat²,

Khan³

2018

J. Bahria Uni. Med. Dent. Coll.

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Objective: Determination of the clinical effectiveness of ciprofloxacin versus ceftriaxone in children with enteric fever on the basis of defervescence within 72 hours of commencement of treatment. Duration and Place of Study: This randomized controlled trial was carried out from 15th May to 15th November 2017 in pediatrics units of Benazir Bhutto Shaheed Teaching Hospital Abbottabad and Jinnah International Hospital Abbottabad. Methodology: 90 children with uncomplicated enteric fever were admitted and divided randomly into two groups, Group A was administered I/V Ceftriaxone 75mg/kg OD and Group B was given I/V Ciprofloxacin 10mg/kg BD for seven days. Response to drug was taken as defervescence within 72 hours while continued fever after 72 hours was taken as no response. The data was analyzed by using SPSS Version 21.00. Results: In our research study 53(58.9%) children were male and 37(41.1%) patients were female. The mean age was 8.43±3.17 years encompassing 4 to 14 years, mean weight of the patients in kg was 29.54±10.8 kg. Efficacy of ceftriaxone group was 93.3% while in ciprofloxacin group 62.2% patients became afebrile in 72 hours. The proportion of achieving defervescence within 72 hours was higher with ceftriaxone than with ciprofloxacin Conclusion: Ceftriaxone is more efficacious in terms of achieving defervescence than ciprofloxacin in children having enteric fever.

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Section: Exact Sig (1-sided)supporting

confidence: 88%

Clinical Efficacy Of Ceftriaxone Versus Ciprofloxacin In Paediatric Enteric Fever

Farhat¹,

Shaukat²,

Khan³

2018

J. Bahria Uni. Med. Dent. Coll.

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“…Splenomegaly was found in 64% of our patients while hepatomegaly was found in 30% only, and lymphadenopathy was found on the clinical examination in 14% of the cases. Hepatomegaly was detected in 18% and splenomegaly was present in 36% of patients in a study done by Saha [23].…”

Section: Discussionmentioning

confidence: 92%

Clinical Characteristics and Antibiotics Sensitivity of Culture Positive Typhoid Fever Patients in Baghdad Teaching Hospital - A Single Center Study

Asreah

Atta

SarKo

2022

Open Access Maced J Med Sci

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BACKGROUND: Enteric fever caused by Salmonella Typhi is an endemic disease in Iraq. Variations in presentations make it a diagnostic challenge. If untreated or treated inappropriately then it is a serious disease with potentially life-threatening complications. The recent emergence of drug resistant strains of S. Typhi is a rising public health problem and a clinical concern to the physician. AIM: The objectives of the study were to assess and describe the patterns of antimicrobial resistance, clinical characteristics, epidemiological distribution, and complications of typhoid fever. PATIENTS AND METHODS: Fifty cases of typhoid fever (culture proven) were collected during the period from February 2019 to November 2019 in the medical wards of Baghdad Teaching Hospital. Detailed history, physical examination, and laboratory investigations were conducted and statistical analysis of the results was done, prospective observational study was conducted. RESULTS: During the study period, 50 cases of typhoid fever were documented, mean age of presentation was 30.7 ± 12.8, 60% of the cases were male gender, gastrointestinal complications were the most common (90%) followed by hematological complications (71%). Mortality of typhoid fever in our study was 2%. High percentage of resistance to third generation cephalosporins, ciprofloxacin, and azithromycin was found (96%, 56%, and 56%, respectively) while good sensitivity to trimethoprim and meropenem was found (94% and 76%, respectively). Significant association was also found between the development of typhoid fever complications and the presence of anemia, thrombocytopenia, lymphopenia, and eosinopenia. Significant association was also found between the complications and the infection with strains resistant to cephalosporins, ciprofloxacin, and azithromycin. CONCLUSIONS: There is a concerning increase in resistance toward cephalosporins, ciprofloxacin, and azithromycin while meropenem and trimethoprim are emerging as effective drugs. There was high incidence of complications found (84%).Lymphopenia, anemia, eosinopenia, and thrombocytopenia are independent risk factors for the development of complications of typhoid fever.

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Study of Clinical Profile and Antibiotic Response in Typhoid Fever at Faridpur Medical College Hospital

Cited by 2 publications

References 9 publications

Clinical Efficacy Of Ceftriaxone Versus Ciprofloxacin In Paediatric Enteric Fever

Clinical Efficacy Of Ceftriaxone Versus Ciprofloxacin In Paediatric Enteric Fever

Clinical Characteristics and Antibiotics Sensitivity of Culture Positive Typhoid Fever Patients in Baghdad Teaching Hospital - A Single Center Study

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