Abstract:Very low birth weight (VLBW) is an important cause of infant mortality and still a challenge for achieving Millennium Development Goal (MDG) in Bangladesh. Our study was to see the risk factors and its outcome of VLBW neonates in a tertiary level Faridpur Medical College Hospital (FMCH), outside capital Dhaka. This prospective cross sectional study was conducted in neonatal Unit of pediatric department in FMCH. All neonates who were admitted here had been selected and we find out the very low birth weight neonates for our study purpose. All anthropometric measurements were taken by us in our department. We took all the informations about neonates within our study period of six months (November 2013 to April 2014) through a prescribed protocol. Total 1126 neonates admitted within our study period of 6 months. Among 1126 neonates 76 of them were VLBW. Among 76 VLBW neonates 38 (50%) were male and 38 (50%) were female, but 22 of them were expired, which was 28.94% of total VLBW neonates. Most expired on month of March which was 38.46%. Among expired VLBW neonates 10 (45.45%) of them were male and 12 (54.55%) of them were female. Total 48 (63.15%) mothers of VLBW neonates delivered at hospital of them Caesarean section occurs in 40 (52.63%) mothers of VLBW neonates and normal vaginal delivery (NVD) occurs in 36 cases (47.37%). Home delivery occurs in mothers of 28 VLBW neonates. Among them 15 (53.57%) were done by traditional birth attendance (TBA), 8 (28.57%) by local dai and 5 (17.86%) by relatives of the family of VLBW neonates. We found mothers of 41 (53.95%) VLBW neonates had premature rupture of membrane (PROM), 8 (10.53%) had eclampsia, 4 (5.26%) had leaking membrane and 4 (5.26%) had history of accident. Maternal age of VLBW neonates are more common between 18 to 24 years of age that was 53.95% (41 in number) but 27 mothers (35.52%) were below 18 years of age . We found in our study that the survival rate of VLBW neonates in our institute is not like developed countries but it is better than many developing countries around the world.

Abstract:The objectives of this present study is to evaluate the clinical profile and pattern of various drugs used in the treatment of typhoid fever. A retrospective analysis of Paediatric patients suffering from typhoid fever was done at Department of Paediatrics, Faridpur Medical College Hospital, Faridpur during the year 2015-2016. Diagnosis of patients was based on clinical features, Widal test and blood culture. The sensitivity pattern of isolates from blood culture was recorded. The mode of presentation, clinical course, treatment history, laboratory investigations reports, antibiotic administered, response to therapy and the complications were recorded. Total number of 50 cases of typhoid fever were studied. Out of these 23 (46%) were males and 27 (54%) were females. Average age of presentation was 8.2 years. Average duration of hospital stay was 10.8 days. Fever was present in all patients. Resistance of S. typhi to amoxicillin, chloramphenicol, ampicillin and co-trimoxazole were significantly high. Ciprofloxacin also showed resistance in 21.4% of cases. Sensitivity to cephalosporin was 100% in our study. Ciprofloxacin was the most commonly used antibiotic in our study (26 patients). Chloramphenicol alone was used in 2 patients and in 3 patients it was given after 6 days of ciprofloxacin treatment. Third generation cephalosporin (ceftriaxone) alone were used in 10 patients. Indiscriminate use of drugs in typhoid fever should be discouraged. Appropriate antibiotic as indicated by sensitivity tests should be employed to prevent the development of resistant strains of S. typhi.

Urinary tract infection is a common complication of Nephrotic syndrome, many cases remain asymptomatic. This study was aimed to determine the possible underlying causes of urinary tract infection in Nephrotic syndrome. The study population in this descriptive study included children aged six months to fourteen years old with Nephrotic syndrome referred to Paediatric ward of Faridpur Medical College Hospital from June 2015 to March 2016. The mean age was 6.12±3.25 years in UTI group and 7.26±3.39 years in without UTI group. Male were predominant in both groups, 15(60.0%) in UTI group and 24(64.9%) in without UTI group. Serum albumin, total protein, urinary protein excretion, the number of white blood cells, hemoglobin, erythrocyte sedimentation rate, blood creatinine, nitrogen, blood urea, serum triglycerides were not statistically significant between the groups. The most common microorganisms involved in urinary tract infection were: Escherichia coli (13%) & Klebsiella (13%). Majority 29(46.8%) patients had fever, 12(19.4%) had diarrhea, 11(17.7%) had bad smell of urine, 10(16.1%) had vomiting associated with diarrhea and 10(16.1%) had respiratory symptoms. Children with nephrotic syndrome are frequently predisposed to urinary tract infection and in most cases it is asymptomatic, often undiagnosed. E. coli is the commonest organism causing UTI.Faridpur Med. Coll. J. Jan 2018;13(1): 35-39

Abstract:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common hereditary enzyme disorder and more than 200 million people have a deficiency in this enzyme. G6PD deficiency is an X-linked enzyme defect, and one of its main signs is the presence of hemolytic anemia. It is a worldwide important cause of neonatal jaundice and causes life threatening hemolytic crisis in childhood. At later ages, certain drugs such as anti-malarial drugs and fava beans cause hemolysis among G6PD deficiency patients. The frequency and severity is influenced by genetic and cultural factors. It is common in Mediterranean, African and some East Asian populations but rare in Bangladeshi peoples. Genetic counseling may be of benefit for patients and their families. Other treatment is symptomatic and supportive.

Abstract:Iron deficiency anaemia and febrile seizures are two common diseases in children worldwide as well as in developing country. A prospective case-control study was carried out in the Department of Paediatrics, Faridpur Medical College Hospital. The study was done during the period from January'2015 to September'2015 with 50 children with first simple febrile seizure as cases and other 50 controls. There were no significant differences in terms of ESR, WBC, platelets, RBC, MCHC, and TIBC levels between the cases and the control group. HB, HCT, MCH, mean serum ferritin and serum iron, were significantly low in the febrile convulsion group as compared to control group.