Study of compound droplet dynamics and separation of immiscible liquids on EWOD DMF

Nahar, Mun Mun; Moon, Hyejin; Wijethunga, Pavithra A. L.

doi:10.1109/nems.2017.8017115

Cited by 1 publication

(1 citation statement)

References 9 publications

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“…Through the application of voltage to the pixel electrode, alterations in the wettability of the solid-liquid interface occur, inducing arbitrary movement of the droplet across the twodimensional plane under the influence of surface tension [3]. Endowed with notable characteristics such as portability, integrity, low cost, minimal reagent consumption, and superior efficiency [4]- [6], DMF holds great promise for applications in in vitro diagnostics, proteomics analysis, single-cell sorting, and nucleic acid testing [7]- [10]. Nevertheless, conventional DMF chips relying on passive arrays encounter significant challenges in terms of expandability, primarily arising from constraints in signal lines and available wiring space.…”

Section: Introductionmentioning

confidence: 99%

41‐2: Invited Paper: Active‐matrix Digital Microfluidics System for High‐Throughput Droplet Sample Processing

Jiang,

Wang,

Zhang

et al. 2024

Symp Digest of Tech Papers

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We introduce a high‐throughput field programmable active‐matrix digital microfluidics system designed for large‐scale biological experiments. The fabricated microfluidics chip consists of a 640×280‐pixel array, each pixel measuring at 100×100 μm . This configuration enables the addressing of individual pixels, facilitating parallel droplet manipulation. The system utilizes 9T2C GOA circuits for generating row scanning signals, and 3T1C pixel circuits to provide driving voltage to individual pixels. The system exhibited a notably elevated proficiency in high‐resolution droplet generation and manipulation, with over 80% droplet division success rate and more than 20 hours of stable single‐droplet movement. The minimum volume of an individual droplet amenable to stable manipulation is 1.2 nL, featuring a droplet resolution of four pixels, which is two orders of magnitude less than the previously reported volume at IEDM. This research lays the foundation for the utilization of digital microfluidics in the realms of in vitro diagnostics and biological and chemical experiments focused on single‐cell analyses.

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