Study of CSF C-reactive protein in meningitis to differentiate bacterial meningitis from aseptic meningitis in children between 1 month and 12 years of age

Natani, Bhagwan Sahai; Goyal, Prashant; Agarwal, Ankit; Bhatia, Subhash; Kumar, Malvika

doi:10.18203/2349-3291.ijcp20171703

Cited by 4 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The similar observations were made by other studies done elsewhere, where the most common isolates were streptococcus pneumonia. 19,20 Among 17,22 The institute mortality of patients with bacterial meningitis was 13.46% which is comparable with the previous studies. 23,24 CRP in CSF was positive in 86 (82.69%) of the CSF samples with culture positivity which was statistically significant (p<0.01) in detecting cases of bacterial meningitis.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

Kamble

2023

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Bacterial meningitis is a significant cause of mortality and morbidity in children worldwide. C-reactive protein (CRP) raises rapidly in the first 24-48 hours of occurrence of bacterial meningitis and in large incremental increases thereafter. The present study was undertaken to find out the correlation between cerebrospinal fluid (CSF)-CRP and bacterial meningitis in paediatric age group. Methods: A total 123 children aged between 1 month to 12 years, in whom meningitis was suspected during the study period were included. Lumbar puncture performed at L3-L4 and CSF sample not more than 3 ml collected in 4 sterile containers. 1ml sent for protein and sugar, 0.5ml each sent for CSF cytology and CSF-CRP, 1ml sent for CSF culture sensitivity and gram staining. Results: The institutional incidence of bacterial meningitis was 3.37%. Fever (93.26%) and altered sensorium (92.30%), were the commonest symptoms and neck rigidity (58.65%) was the commonest meningeal sign. The neurologic assessment showed abnormal mental status (34.61%), abnormal cranial nerve findings (10.57%) and abnormal motor function (13.46%). The mean CRP level was 15.36±0.67 mg/l. Pneumococcus was the commonest isolated organism (53.48%) in CSF culture. The institutional mortality was 13.46%. CSF-CRP was positive in 104 (82.69%) of the culture-positive cases with a sensitivity of 82.69%, specificity 84.21%, positive predictive value 96.62% and negative predictive value of 47.05%. Conclusions: CRP levels in CSF offers a moderate sensitivity and specificity as well as high positive predictive value. This indicates that CSF-CRP is a better marker in differentiating bacterial meningitis and it can serve as a useful screening test for bacterial meningitis.

show abstract

Section: Discussionsupporting

confidence: 87%

“…A similar finding was also reported in various other studies. 5,19,22 The level of CRP in CSF is variable and usually less than that of plasma. It depends on the amount of CRP released into CSF from plasma by ultrafiltration and secretion by inflamed meninges.…”

Section: Discussionmentioning

confidence: 99%

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

Kamble

2023

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…Belagavi et al 13 has shown that CSF-CRP has sensitivity and specificity of 83.3% and 100%, respectively, with an accuracy of 98% in adults with meningitis. Natani et al 14 conducted a study in children aged between 1 mo and 12 y with meningitis and had shown that CSF-CRP has sensitivity and specificity of 72.92% and 85.71%, respectively, with an accuracy of 78.89%. The study concluded that CSF-CRP can be used as an initial test for the diagnosis of bacterial meningitis.…”

Section: Discussionmentioning

confidence: 99%

Role of CSF-CRP as a Diagnostic Marker in Neonatal Meningitis

Balasubramanin

Bandiya

Niranjan

et al. 2018

Journal of Neonatology

View full text Add to dashboard Cite

Background: Cerebrospinal fluid C-reactive protein (CSF-CRP) in adults and children has been shown to be useful for the diagnosis of bacterial meningitis; however, it has not been evaluated in neonates. Objective: To study the role of CSF-CRP as a diagnostic marker in neonatal meningitis and determine optimal cut-offs for diagnosis. Study Design: Prospective observational study from June 2017 to December 2017. Methodology: Routine CSF analysis along with CSF-CRP was performed in neonates who qualified for lumbar puncture. Results: At a cut-off value of 3.8 mg/L, CSF-CRP had a sensitivity of 0.96 and a specificity of 0.44, with positive and negative predictive values of 0.63 and 0.91, respectively. Conclusion: CSF-CRP has higher diagnostic efficiency than other CSF markers. At a value of 3.8 mg/L, it has a high sensitivity and a negative predictive value to rule out meningitis.

show abstract

Comparing CSF Parameters Between Children Diagnosed With Bacterialand Aseptic Meningitis

Sah¹,

Manandhar

Pareek

et al. 2021

ijsr

View full text Add to dashboard Cite

Introduction: Diagnosis of meningitis in children cannot rely on clinical examination. Present study aimed to evaluate the role of CSF examination in differentiating bacterial from aseptic meningitis in children less than 14 years of age. Methodology: This observational crosssectional study included children aged 1 month to 14 years with a diagnosis of meningitis. Children were classied as bacterial meningitis or aseptic meningitis. CSF examination was conducted to measure CRP, cell count, neutrophil count, lymphocytes, glucose levels and protein levels. Statistical comparison was made between children with bacterial meningitis and aseptic meningitis. Results: Children aged less than 2 years had the highest incidence of meningitis to the extent of 30.6%. CSF examination revealed than CRP was found to be positive in 81.82% of the patients with bacterial meningitis, while only 3.45% of the patients with aseptic meningitis had a positive CRP (p value < 0.001). It was observed that median cell count and neutrophil count were signicantly higher among patients with bacterial meningitis as compared to those with aseptic meningitis. While, median lymphocyte count was signicantly lower in patients with bacterial meningitis as compared to those with aseptic meningitis (p value < 0.001). Furthermore, we observed that CSF glucose less than 50% of that blood levels was observed in 81.82% of the patients with bacterial meningitis, which was signicantly higher than those diagnosed with aseptic meningitis (p value < 0.05). Conclusions: CSF CRP and biochemical parameters like cell count, neutrophils and glucose levels can aid in differentiating bacterial from aseptic meningitis

show abstract

Study of CSF C-reactive protein in meningitis to differentiate bacterial meningitis from aseptic meningitis in children between 1 month and 12 years of age

Cited by 4 publications

References 13 publications

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

A study of cerebrospinal fluid C-reactive protein in bacterial meningitis among paediatric age group in a tertiary care hospital

Role of CSF-CRP as a Diagnostic Marker in Neonatal Meningitis

Comparing CSF Parameters Between Children Diagnosed With Bacterialand Aseptic Meningitis

Contact Info

Product

Resources

About