Study of Cucurbita extract effect on changes of AGEs, lipid and glycemic profile and CRP in type 1 diabetic rats

Abstract

Background: Clinically, diabetes is an important risk factor or a range of diseases including nephropathy,retinopathy, angiopathy and deficiency and it is increasing in prevalence according to some estimates. (Cucurbita pepo L.) from the cucurbitaceae family has a low calorie but high nutritional and medical value. The aim of this study was to observe the effect of cucurbita extract on serum factors of STZ induced diabetic rats including glucose level AGEs, lipid profile (cholesterol, HDL, LDL, and TG) and CRP. Material and methods: Diabetes type1 was induced to Male albino-wistar rats by STZ at a dosage of 50 mg kg -1. 17 rat were divided into three groups randomly including diabetic treated with extract, diabetic control and normal group. Diabetic group were force fed orally by cucurbita extract. The animals were anesthetized with ether at the end of 30 days and the blood was collected by syringe from their hearts for estimation of plasma glucose, TG, HDL, LDL, total cholesterol, CRP and AGEs Results: After measuring the serum factors and compares the result of the three groups to each other meaningful difference that shows the positive effect of cucurbita extract has been seen. Conclusion: According to the results we suggest that squash extract could have positive effect on regulating some of blood elements like glucose which are under the bad effect of diabetes type1 in rats. But more investigations are needed in this field to demonstrate the real benefits of cucurbita in curing diabetes and its related signs.

In Vitro Role of Pumpkin Parts as Pharma-Foods: Antihyperglycemic and Antihyperlipidemic Activities of Pumpkin Peel, Flesh, and Seed Powders, in Alloxan-Induced Diabetic Rats

“…Abuelgassim and Al-Showayman [ 50 ] studied the effect of pumpkin seed supplementation in diet on serum glucose level in atherogenic rats and found nonsignificant data of blood glucose level in atherogenic rats and rats fed with pumpkin seeds diet. Results supporting our study were present when Sayahi and Shirali [ 51 ] studied the effect of pumpkin ( Cucurbita pepo ) fruit extract on serum glucose concentrations and found a significant decrease in blood glucose level in diabetic groups treated with pumpkin fruit extract.…”

“…Mohamed et al [ 60 ] studied the effect of substituting pumpkin seed protein isolate at 25, 50, 75, and 100% level with casein on serum lipid levels in CCl 4 -intoxicated rats and found supporting results. Sayahi and Shirali [ 51 ] studied the effect of pumpkin ( Cucurbita pepo ) fruit extract on serum lipid concentrations, and contradictory results for TG and TC were obtained with a nonsignificant increase in TG as in diabetic group, TG were 92.40 mg/dl, and in group treated with pumpkin extract, TG were 93.16 mg/dl, and a significant increase in TC as in diabetic group TC was 66.60 mg/dl, and it was increased to 73.83 mg/dl in diabetic group treated with pumpkin fruit extract. Results for LDL-C and HDL-C were similar to our study as an increase in HDL-C was observed (diabetic rats' group: 34.28 mg/dl and pumpkin extract-treated group: 38.76 mg/dl), and decrease in LDL-C was observed (diabetic rats' group: 14.60 mg/dl and pumpkin extract-treated group: 13.16 mg/dl).…”

The Effect of Bitter Melon (Momordica charantia L.) Leaves Extractonon Glycated Albumin in Diabetic Foot Ulcers: Randomized Controlled Trial

“…Diabetes mellitus (DM) has increased the prevalence in the world, especially in developing countries 1,2 . The prevalence numbers in patients with diabetes mellitus were growing rapidly in the world that might generally correlated lead as with living in the urban area, increasing older adult population, and lifestyle alteration 3 . Diabetes is a metabolic disease characterized by hyperglycemia and impaired carbohydrate metabolism, fat, and insulin resistance, and it becomes one of the causes of death in the world 4 .…”

Effect of Ethanol Extract of Cucurbita pepo Leaves on the Lipid Profile of Wistar Albino Rats

“…In the present work, the effect of dietsupplementation with the extract of C. pepo leaves on lipid profile of rats was studied to observe for hypolipidemic potential. Previous works in the area have paid mind to the hypolipidemic potential of the fruits and seeds [11][12][13]. Hence, this work is novel in the sense that it pays attention to the leaves, which hitherto, had received very little attention.…”