Study of Different Encapsulating Agents for the Microencapsulation of Vitamin B12

Carlan, Ioana C.; Estevinho, Berta N.; Rocha, Fernando

doi:10.30638/eemj.2018.086

Cited by 11 publications

(2 citation statements)

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“…In addition, a decrease in the vitB12 time release was observed, suggesting more bioavailability for the digestive system. In a comparative study, the encapsulation of vitamin B12 using different shell materials by the spray-drying technique was stated [62]. The results showed spherical and smooth B12 microcapsules with a product yield between 27% and 50%.…”

Section: Encapsulation Of Water-soluble Vitamins By Spray Dryingmentioning

confidence: 99%

Recent Advances in Water-Soluble Vitamins Delivery Systems Prepared by Mechanical Processes (Electrospinning and Spray-Drying Techniques) for Food and Nutraceuticals Applications—A Review

Coelho

Estevinho

Rocha

2022

Foods

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Water-soluble vitamins are essential micronutrients in diets and crucial to biochemical functions in human body physiology. These vitamins are essential for healthy diets and have a preventive role against diseases. However, their limitations associated with high sensitivity against external conditions (temperature, light, pH, moisture, oxygen) can lead to degradation during processing and storage. In this context, microencapsulation may overcome these conditions, protecting a biomolecule’s bioavailability, stability, and effectiveness of delivery. This technique has been used to produce delivery systems based on polymeric agents that surround the active compounds. The present review focuses on the most relevant topics of water-soluble vitamin encapsulation using promising methods to produce delivery vehicles—electrohydrodynamic (electrospinning and electrospraying) and spray-drying techniques. An overview of the suitable structures produced by these processes is provided. The review introduces the general principles of the methods, advantages, disadvantages, and involved parameters. A brief list of the used physicochemical techniques for the systems’ characterization is discussed in this review. Electrospinning and spray-drying techniques are the focus of this investigation in order to guarantee vitamins’ bioaccessibility and bioavailability. Recent studies and the main encapsulating agents used for these micronutrients in both processes applied to functional food and nutraceutical areas are highlighted in this review.

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Section: Encapsulation Of Water-soluble Vitamins By Spray Dryingmentioning

confidence: 99%

Recent Advances in Water-Soluble Vitamins Delivery Systems Prepared by Mechanical Processes (Electrospinning and Spray-Drying Techniques) for Food and Nutraceuticals Applications—A Review

Coelho

Estevinho

Rocha

2022

Foods

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“…1,8,9 Electrohydrodynamic methods are of interest in the scientific community as well as in industry. 8,28 Previous studies on the encapsulation of vitamins 17,[29][30][31][32] were developed by the authors, using electrohydrodynamic methods. 9,17,33 A promising vitamin B12 encapsulated into zein microstructures was reported by Coelho et al for food and nutraceutical applications.…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed B‐complex vitamins/zein microparticles for drug sustained release and antioxidant applications

Coelho,

Giron,

Rocha

et al. 2023

J of Chemical Tech & Biotech

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B‐complex vitamins are important compounds for the human body, namely for brain and cell function and preventing infections and diseases. However, the instability associated to these vitamins is a critical problem. Their encapsulation into delivery systems that are able to protect them against undesirable conditions can be one solution. The present study focuses on the encapsulation of the B‐complex vitamin at different concentrations (1, 5 and 10% w/w) by an electrohydrodynamic technique. The synergistic effect of the vitamins B in the enhancing antioxidant activity of the microstructures is investigated. Zein, a prolamine protein found in corn, was the chosen wall material. The matrices were analysed in terms of the surface morphology, encapsulation efficiency, antioxidant activity and release of the B‐vitamins from the zein microstructures. Spherical microbeads were produced with size between 0.32 and 0.38 μm and with high efficiency of encapsulation. Vitamins release profiles were obtained and the results suggested similar release profiles (in the range of 10 ‐ 40 hours) for the vitamin B3, vitamin B6, B3 plus B6 and B3 plus B6 plus B9. The Weibull model was used to adjust the experimental release profiles. Regarding the assessed antioxidant activity, it was possible to visualize an activity enhancement of the vitamin B3, vitamin B9, combined vitamins B6 and B9. Overall, the proposed encapsulation microsystems are a suitable alternative for the encapsulation of sensitive bioactive ingredients, such as vitamins, against external conditions, maintaining the indispensable stability essential for food, nutraceutical and pharmaceutical products.This article is protected by copyright. All rights reserved.

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Production of vitamin B1 microparticles by a spray drying process using different biopolymers as wall materials

2020

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The aim of this work was to microencapsulate vitamin B1 by spray‐drying using different encapsulating agents (arabic gum, carrageenan, chitosan, maltodextrin, modified chitosan, modified starch, pectin, sodium alginate, and xanthan) and to characterize the microcapsules and study their release. Microcapsules with a 0.25% (w/w) content of vitamin B1 were produced. The product yield results ranged from 17%‐52% and the encapsulation efficiency from 66%‐100%. Three categories of morphology, regular spherical shape, irregular spherical shape with rough surface, and irregular shape, were identified. Their sizes, determined by laser granulometry, ranged from 0.11‐1.32 μm, in terms of number distribution, and from 3.76‐34.43 μm, in volume distribution. Controlled release studies were performed by spectrophotometric analysis, in deionized water (20°C) and simulated gastric fluid (37°C). Different release behaviours were observed from just 10 seconds (modified starch) up to more than 24 hours (xanthan). Kinetic models such as zero‐order, first‐order, Higuchi, Korsmeyer‐Peppas, and Weibull were applied. The Weibull model showed the best fitting with the experimental data. All release tests were repeated after 4 months and showed good stability over time. A mass loss of vitamin B1 lower than 20% was detected. This study demonstrates the possibility of encapsulating vitamin B1 using different encapsulating agents by a spray‐drying technique. Depending on the intended applications, for fast release, adequate results were obtained for maltodextrin, arabic gum, modified chitosan, and sodium alginate, and for slow release, adequate results were only obtained for chitosan and pectin.

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Study of Different Encapsulating Agents for the Microencapsulation of Vitamin B12

Cited by 11 publications

References 0 publications

Recent Advances in Water-Soluble Vitamins Delivery Systems Prepared by Mechanical Processes (Electrospinning and Spray-Drying Techniques) for Food and Nutraceuticals Applications—A Review

Recent Advances in Water-Soluble Vitamins Delivery Systems Prepared by Mechanical Processes (Electrospinning and Spray-Drying Techniques) for Food and Nutraceuticals Applications—A Review

Electrosprayed B‐complex vitamins/zein microparticles for drug sustained release and antioxidant applications

Production of vitamin B1 microparticles by a spray drying process using different biopolymers as wall materials

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