Study of effect of 1% sodium hyaluronate application on tympanic membrane perforation

Abstract

<p class="abstract"><strong>Background:</strong> Topical applications of hyaluronic acid have been found to have beneficial effects on closure of tympanic membrane perforations.<strong> </strong>The aim of the study was to evaluate the role of 1% sodium hyaluronate in the repair of small or medium sized dry central tympanic membrane perforation and improvement in hearing following closure of tympanic membrane perforation.</p><p class="abstract"><strong>Methods:</strong> 50 patients with dry central perforation of inflammatory or traumatic origin were taken up. Maximum of 4 applications of 1% sodium hyaluronate were given at weekly intervals. Final mapping for closure of tympanic membrane perforation and hearing assessment was done after 3 months. </p><p class="abstract"><strong>Results:</strong> 26 perforations closed completely while 18 perforations showed significant reduction in size. Thus 44 or 88% perforations showed positive response to 1% sodium hyaluronate application. Hearing Improvement was observed on pure tone audiometry with the average hearing gain in patients after complete closure of tympanic membrane perforation was 12.40 dB with p value of 0.001.</p><p class="abstract"><strong>Conclusions:</strong> Study showed the beneficial effects of 1% sodium hyaluronate application in closure of small and medium size perforations of tympanic membrane perforation and improvement in hearing.</p><p class="abstract"> </p>

Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations

“…No significant difference was observed between the treated and control group with 85.65% of the control group closing with a mean of 10.6 ± 5.23 weeks, the treated group had a closure rate of 94.8% and a mean closure time of 6.61 ± 4.59 weeks. A study from 2018 using HyA for TM repair [15] assessed fifty patients with dry chronic TM perforations of 1−3mm who received a topical application of 1% sodium hyaluronate, four times a week for a month. Each patient was followed up weekly for the first four weeks, then three months after the last application of 1% sodium hyaluronate.…”

“… Biomolecule Results Model TM perforation Refs. EGF 100% closure rate range 3–12 days Human Chronic [68] EGF 96.2% closure rate range 3–14 days Human Subacute [69] Fat graft soaked in PRP Increase in adipocyte area, decrease in granulation tissue area in comparison to fat graft alone Rat Acute [70] FGF-2 98.1% closure for non-pathological TMP, 10.1 ± 4.6 days Human Not specified [71] 86.7% closure rate for pathological TMP, 19.1 ± 7.3 days 1% HyA topical application 52% closure Human Acute and chronic, 1–3 mm [15] 36% TMP size reduction. Time of closure not specified EGF and FGF-2 EGF – 91.11% closure rate 9-16.5 days Human Acute dry [72] FGF-2 – 93.18% closure rate 7-15 days Human Insulin Accelerated healing, 100% closure 5-7days.…”