Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations

Sainsbury, Elizabeth; Amaral, Rui; Blayney, A. W.; Walsh, R. M.; O’Brien, Fergal J.; O’Leary, Cian

doi:10.1016/j.bbiosy.2022.100046

Cited by 13 publications

(14 citation statements)

References 91 publications

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“…Surgery is only indicated for chronic TM perforations (over 3 months) and this procedure is called myringoplasty (or tympanoplasty if ossicles are involved), which involves the placement of an autologous graft (typically temporalis fascia or auricular cartilage) over or under the defect to encourage wound healing and restore hearing. The success rate for such surgery is approximately 87% ( Tan et al, 2016 ), but the harvesting of autologous grafts is associated with donor site morbidity (infection and pain) and higher operation cost ( Villar-Fernandez and Lopez-Escamez, 2015 ; Sainsbury et al, 2022 ).…”

Section: Current and Emerging Therapeutic Optionsmentioning

confidence: 99%

“…For the repair of TM, much research has been focused on developing biocompatible scaffolds using natural or synthetic materials such as collagen, chitosan, decellularized tissue and polylactic acid (PLA) ( Hussain and Pei, 2021 ; Sainsbury et al, 2022 ). Some of the current commercially available scaffolding materials indicated for myringoplasty are EpiFilm ® (Medtronic, Ireland), which is a hyaluronic acid-derived implantable device, and acellular dermal allografts such as Alloderm (Allergan, Ireland) ( Vos et al, 2005 ; Sayin et al, 2013 ).…”

Section: Current and Emerging Therapeutic Optionsmentioning

confidence: 99%

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Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear

Delaney,

Liew,

Lye

et al. 2023

Front. Pharmacol.

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Despite significant advances in the development of therapeutics for hearing loss, drug delivery to the middle and inner ear remains a challenge. As conventional oral or intravascular administration are ineffective due to poor bioavailability and impermeability of the blood-labyrinth-barrier, localized delivery is becoming a preferable approach for certain drugs. Even then, localized delivery to the ear precludes continual drug delivery due to the invasive and potentially traumatic procedures required to access the middle and inner ear. To address this, the preclinical development of controlled release therapeutics and drug delivery devices have greatly advanced, with some now showing promise clinically. This review will discuss the existing challenges in drug development for treating the most prevalent and damaging hearing disorders, in particular otitis media, perforation of the tympanic membrane, cholesteatoma and sensorineural hearing loss. We will then address novel developments in drug delivery that address these including novel controlled release therapeutics such as hydrogel and nanotechnology and finally, novel device delivery approaches such as microfluidic systems and cochlear prosthesis-mediated delivery. The aim of this review is to investigate how drugs can reach the middle and inner ear more efficiently and how recent innovations could be applied in aiding drug delivery in certain pathologic contexts.

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Section: Current and Emerging Therapeutic Optionsmentioning

confidence: 99%

Section: Current and Emerging Therapeutic Optionsmentioning

confidence: 99%

Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear

Delaney,

Liew,

Lye

et al. 2023

Front. Pharmacol.

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“…Significant attention has been paid lately to the methods of re-generative medicine in the closure of TM perforations [ 18 ]. Since the 1990s, with the development of tissue engineering, synthetic materials have demonstrated great potential for TM restoration [ 19 ]. The use of tissue-engineered scaffolds provides significant advantages such as the reduction in surgery time and minimizing surgical tissue damage, reduction in economic expenses, and an increase in the percentage of positive morphofunctional results [ 5 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Collagen Matrix to Restore the Tympanic Membrane: Developing a Novel Platform to Treat Perforations

Svistushkin,

Kotova,

Zolotova

et al. 2024

Polymers

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Modern otology faces challenges in treating tympanic membrane (TM) perforations. Instead of surgical intervention, alternative treatments using biomaterials are emerging. Recently, we developed a robust collagen membrane using semipermeable barrier-assisted electrophoretic deposition (SBA-EPD). In this study, a collagen graft shaped like a sponge through SBA-EPD was used to treat acute and chronic TM perforations in a chinchilla model. A total of 24 ears from 12 adult male chinchillas were used in the study. They were organized into four groups. The first two groups had acute TM perforations and the last two had chronic TM perforations. We used the first and third groups as controls, meaning they did not receive the implant treatment. The second and fourth groups, however, were treated with the collagen graft implant. Otoscopic assessments were conducted on days 14 and 35, with histological evaluations and TM vibrational studies performed on day 35. The groups treated with the collagen graft showed fewer inflammatory changes, improved structural recovery, and nearly normal TM vibrational properties compared to the controls. The porous collagen scaffold successfully enhanced TM regeneration, showing high biocompatibility and biodegradation potential. These findings could pave the way for clinical trials and present a new approach for treating TM perforations.

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“…Tissue engineering is a field concerned with the development of functional tissues by the combination of cells, scaffolds, biomaterials, and biologically active ingredients. The main aim of tissue engineering is to fabricate functional constructs that restore and improve damaged tissue functions [1][2][3][4][5][6][7][8][9]. It was first introduced in the late 1980s in a meeting held by the National Science Foundation in the USA [10], while the first published paper that used the term tissue engineering as it is known today was in 1991 by a paper entitled "Functional Organ Replacement: The New Technology of Tissue Engineering" [11], while in 2008, the first completely tissue-engineered organ was a trachea transplanted in a 30-year-old woman to replace an end-staged damaged airway [12,13].…”

Section: Introductionmentioning

confidence: 99%

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

2022

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Tissue engineering has emerged as an interesting field nowadays; it focuses on accelerating the auto-healing mechanism of tissues rather than organ transplantation. It involves implanting an In Vitro cultured initiative tissue or a scaffold loaded with tissue regenerating ingredients at the damaged area. Both techniques are based on the use of biodegradable, biocompatible polymers as scaffolding materials which are either derived from natural (e.g. alginates, celluloses, and zein) or synthetic sources (e.g. PLGA, PCL, and PLA). This review discusses in detail the recent applications of different biomaterials in tissue engineering highlighting the targeted tissues besides the in vitro and in vivo key findings. As well, smart biomaterials (e.g. chitosan) are fascinating candidates in the field as they are capable of elucidating a chemical or physical transformation as response to external stimuli (e.g. temperature, pH, magnetic or electric fields). Recent trends in tissue engineering are summarized in this review highlighting the use of stem cells, 3D printing techniques, and the most recent 4D printing approach which relies on the use of smart biomaterials to produce a dynamic scaffold resembling the natural tissue. Furthermore, the application of advanced tissue engineering techniques provides hope for the researchers to recognize COVID-19/host interaction, also, it presents a promising solution to rejuvenate the destroyed lung tissues. Graphical abstract

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Tissue engineering and regenerative medicine strategies for the repair of tympanic membrane perforations

Cited by 13 publications

References 91 publications

Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear

Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear

Collagen Matrix to Restore the Tympanic Membrane: Developing a Novel Platform to Treat Perforations

Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review

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