Study of factors influencing the decreased HDL associated PON1 activity with aging

Serés, I.; Paragh, György; Deschene, Elaine; Fülöp, Tamás; Khalil, Abdelouahed

doi:10.1016/j.exger.2003.08.001

Cited by 153 publications

(130 citation statements)

References 40 publications

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“…[24] Moreover, PON activity decreases with increased age. [25] In our study, the pre-treatment serum PON levels of the ISSHL patients were significantly (p<0.05) higher than those of controls. The pre-treatment serum PON levels were high in recovered (either complete or partial recovery) patients after treatment.…”

Section: Discussionmentioning

confidence: 61%

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Düzer¹

2014

Kulak Burun Bogaz Ihtis Derg

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Objectives: This study aims to investigate the correlation between serum anti-heat-shock protein 70 (anti-HSP 70) levels, serum paraoxonase (PON) levels and prognosis of idiopathic sudden sensorineural hearing loss (ISSHL). Patients and Methods:Twenty-five patients with ISSHL as the study group and 25 healthy volunteers as the control group were enrolled in this study. Blood samples were obtained from all patients before the treatment initiation and on the 10 th day of the treatment from only patients of the study group. Idiopathic sudden sensorineural hearing loss was defined as the hearing loss between 250-6.000 Hz frequencies. The recoveries in the hearing thresholds were evaluated at 10 days of the treatment.Results: When the pre-treatment serum PON, anti-HSP 70 levels and the post-treatment serum PON, anti-HSP 70 levels of the patients with ISSHL were compared, we observed that the post-treatment serum PON levels of the recovered patients increased, while the post-treatment serum anti-HSP 70 levels of recovered patients decreased. Conclusion:We believe that serum levels of anti-HSP 70 and PON can be used as markers for estimating and evaluating the prognosis of ISSHL patients.Key Words: Heat-shock protein 70; idiopathic sudden sensorineural hearing loss; paraoxonase; prognosis.

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Section: Discussionmentioning

confidence: 61%

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Düzer¹

2014

Kulak Burun Bogaz Ihtis Derg

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“…The PON1 activity was measured in the absence (basal activity) and presence of NaCl (salt-stimulated activity) 6 . Briefly, the rate of paraoxon hydrolysis was measured by the increase of absorbance at 412 nm at 25 °C.…”

Section: Paraoxonase Activitymentioning

confidence: 99%

Association of paraoxonase activity and atherosclerosis in patients with chronic hepatitis B

Karsen¹,

Binici²,

Sünnetçioğlu³

et al. 2012

Af Hlth Sci

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Background: The hepatitis B virus is a significant pathogen that causes cirrhosis, and hepatocellular cancer as a result of the damage it causes to liver cells. Its infection affects more than 400 million people globally. Although there is an effective vaccine and treatment methods, almost 1, 000, 000 people die every year. Objective: To investigate paraoxonase and arylesterase activities along with oxidative status parameters and serum lipid levels, and to find out if there is any increased susceptibility to atherogenesis. Methods: Thirty-four subjects with chronic hepatitis B and 39 healthy subjects as control were enrolled in the study. Age, body mass index and gender, Serum Triglycerides (TG), High-density Lipoprotein (HDL) and Low-Density lipoprotein (LDL) levels, serum paraoxonase-1 and arylesterase activities were determined. Oxidative and antioxidative statuses were evaluated by measuring serum-free sulfhydryl groups, lipid hydroperoxide levels, total antioxidant capacity, total oxidant status, and oxidative stress index. Results: Serum TG and LDL levels were higher while serum HDL levels were lower in patients with chronic hepatitis B than in controls but the differences did not reach statistical significance. Serum paraoxonase-1 and arylesterase activities, plasma free sulfhydryl groups, and total antioxidant capacity were significantly lower in patients than in controls (p=0.018, p=0.005, p<0.001, p=0.037 respectively), while lipid hydroperoxide, total oxidant status, and oxidative stress index were significantly higher (for all p<0.001). Conclusion:The diminution in the paraoxonase-1 and arylesterase activities could contribute to the accelerated development of atherosclerosis in patients with chronic hepatitis B.

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“…We carried out multiple regression analysis using the stepwise method to determine the variables best predicted PON1 arylesterase activities adjusting for age, sex, BFP, HDL-C, leptin, adiponectin in the model. At first (Model 1), a less adjusted model was constructed in which, beside the two adipokines that showed significant univariate correlation with PON1 arylesterase activity, the impact of sex and age were tested, since our previous investigation showed significant decrease in PON1 activity with age through the whole lifetime (33). Although HDL-C and BFP did not show significant univariate correlation with PON1 arylesterase activity, we investigated their impact in Model 2 adjusting them to the previous parameters in Model 1, since PON1 is associated to a subfraction of HDL and BFP reflects well the degree of obesity in adolescent children (34).…”

mentioning

confidence: 99%

Human Paraoxonase-1 Activity in Childhood Obesity and Its Relation to Leptin and Adiponectin Levels

et al. 2010

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Childhood obesity is a predisposing factor for adult cardiovascular diseases. Human serum paraoxonase (PON1) may protect against atherosclerosis by hydrolyzing lipid peroxides in oxidized LDL. Alterations and potential correlations of PON1 activities, leptin and adiponectin levels in childhood obesity were studied. We measured PON1 paraoxonase and arylesterase activities, anthropometric parameters, leptin and adiponectin levels in 59 white, obese (obese group-OB: BMI corrected for age: 95.1 Ϯ 3.5 percentile, age: 11.9 Ϯ 1.6 y) and 51 normal-weight children (control group-C: BMI corrected for age: 64.1 Ϯ 8.4 percentile, age: 12.0 Ϯ 3.9 y ng/mL; p Ͻ 0.0001) and lower adiponectin levels (OB: 7.56 (5.69/12.06) g/mL versus. C: 11.51 (8.84/14.49) g/mL; p Ͻ 0.001) compared with the normal-weight group. PON1 arylesterase activity showed inverse univariate correlation with leptin (r ϭ Ϫ0.29; p Ͻ 0.05) and positive correlation with adiponectin levels (r ϭ 0.39; p Ͻ 0.01). In multiple regression analysis adiponectin was strongly associated with PON1 arylesterase activity in obese children (␤ ϭ 0.45, p Ͻ 0.02). Our results emphasize the importance of the investigated metabolic alterations which may have further effects on cardiovascular morbidity and mortality in later adulthood. Altered levels of leptin, adiponectin and PON1 activities may be useful markers beside the general risk factors in childhood obesity.

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Study of factors influencing the decreased HDL associated PON1 activity with aging

Cited by 153 publications

References 40 publications

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Association of paraoxonase activity and atherosclerosis in patients with chronic hepatitis B

Human Paraoxonase-1 Activity in Childhood Obesity and Its Relation to Leptin and Adiponectin Levels

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