Study of gallbladder cancer in the light of proteomics

Pradhan, Arpit Kumar; Saha, Soham; Ghosh, Shyamasree

doi:10.7287/peerj.preprints.1357v2

Cited by 2 publications

(2 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Non-synonymous SNPs (nsSNPs) results in amino acid sequence alterations in proteins and can lead to structural and functional alteration in the protein structure (6)(7) . Advancements in high throughput sequencing have increased the number of DNA sequence variants being submitted but the real challenge remains in understanding 4 their role in diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Insilico analysis of structural and functional impact of SNPs in Pleckstrin

Pradhan

Jainarayanan²,

Nithishwer³

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

Pleckstrin (PLEK) gene has been associated with a variety of disorders including autoimmune, inflammatory diseases and cancer. Mutation in this gene has been reported to be associated with autoimmune celiac disease (CD), increased atrophy in multiple sclerosis (MS), obstructive sleep apnea (OSA), abdominal aortic aneurysms, over expression in inflammatory disorders including periodontis, risk for ependymoma relapse, bladder cancer, melanoma, lung, and colorectal cancer revealing the importance of study of the PLEK. PLEK gene has been reported from other animals and therefore we have studied the molecular evolution of the PLEK gene by insilico approaches. Single nucleotide polymorphisms (SNPs), in humans have been reported to cause potential structure-function alteration in proteins. In this study we have tried to understand by insilico approaches the (i) molecular evolution of PLEK and (ii) the impact of potentially deleterious single non-synonymous SNPs (nsSNPs) on the structure and function of Pleckstrin protein. We report for the first time using molecular dynamic simulation (MDS), the impact of SNPrs17035364 and rs3816281 on the structural alterations of Pleckstrin with implications in altering its biological function which may find importance as diagnostic markers.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Computational models and tools have helped screening of SNPs that affect the function of proteins and provides an insight to the structural basis of disease-causing mutation. Insilico approaches to study SNPs have enabled us to understand the structural modifications in certain protein and their direct impact in gall bladder cancer 6,7 .…”

Section: Introductionmentioning

confidence: 99%