Study of Gallium Oxide Nanoparticles Conjugated with β-Cyclodextrin: An Application To Combat Cancer

Ganguly, Bichitra Nandi; Verma, Vivek; Chatterjee, Debanuj; Satpati, Biswarup; Debnath, Sushanta; Saha, Partha

doi:10.1021/acsami.6b04807

Cited by 32 publications

(24 citation statements)

References 36 publications

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“…In the spectrum of GaCurNPs, most of the peaks corresponding to the curcuminic structure were observed with a slight shift in the wavenumber and intensity due to the interaction with GaO(OH). 36 No characteristic bands of GaO(OH) were observed in the FT-IR spectrum possibly due to overlapping and chemical modification. 37 Unlike in curcumin, the O–H stretching of enolic and phenolic parts merged to form a broad peak centered at 3330 cm –1 .…”

Section: Resultsmentioning

confidence: 99%

Gallium–Curcumin Nanoparticle Conjugates as an Antibacterial Agent against Pseudomonas aeruginosa: Synthesis and Characterization

et al. 2022

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Combating antibiotic resistance has found great interest in the current clinical scenario. Pseudomonas aeruginosa , an opportunistic multidrug-resistant pathogen, is well known for its deadly role in hospital-acquired infections. Infections by P. aeruginosa are among the toughest to treat because of its intrinsic and acquired resistance to antibiotics. In this study, we project gallium–curcumin nanoparticle (GaCurNP) conjugates as a prospective candidate to fight against P. aeruginosa . The synthesized GaCurNPs were spherical with an average size ranging from 25–35 nm. Analysis by Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy deduced the nature of interaction between gallium and curcumin. Conjugate formation with gallium was found to improve the stability of curcumin at the physiological pH. When tested after 24 h of contact, at the physiological pH and 37 °C, the degradation of curcumin bound in the GaCurNPs was 26%, while that of native curcumin was 95%. The minimum inhibitory concentration (MIC) of GaCurNPs was found to be 82.75 μg/mL for P. aeruginosa ( ATCC 27853). GaCurNPs also showed excellent biofilm inhibition at 4MIC concentration. Raman spectroscopic analysis showed that GaCurNPs are capable of disrupting the cells of P. aeruginosa within 3 h of contact. Live/dead imaging also confirmed the compromised membrane integrity in cells treated with GaCurNPs. Scanning electron microscopy analysis showed membrane lysis and cell structure damage. The AlamarBlue assay showed that when L929 cell lines were treated with GaCurNPs with concentrations as high as 350 μg/mL, the cell viability elicited by the nanoparticles was 70.89%, indicating its noncytotoxic nature. In short, GaCurNPs appear to be a promising antibacterial agent capable of fighting a clinically significant pathogen, P. aeruginosa .

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Section: Resultsmentioning

confidence: 99%

Gallium–Curcumin Nanoparticle Conjugates as an Antibacterial Agent against Pseudomonas aeruginosa: Synthesis and Characterization

et al. 2022

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“…In addition, we confirmed that the diffraction patterns on Figure 1 can be assigned to the orthorhombic GaOOH structure and are in agreement with literature reports. 25 …”

Section: Results and Discussionmentioning

confidence: 99%

Ga Ion-Enhanced and Particle Shape-Dependent Generation of Reactive Oxygen Species in X-ray-Irradiated Composites

2018

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The reported results test the effects of the collective behavior hypothesized to contribute to the production of more reactive oxygen species (ROS) in vitro and result in an enhanced radiosensitization. The role of particle shape in composites with gallium oxyhydroxide (GaOOH) particles and Matrigel is studied. Particles of two different shapes are embedded into the gel to understand only the materials effect on the generation of ROS rather than cell penetrating variations. The paper reports materials characterization by scanning electron microscopy and X-ray diffraction. The stability of the particles within the composite is assessed by quantification of leached metal using inductively coupled plasma mass spectrometry. The amount of ROS in each construct under variable radiation conditions is quantified in the presence and absence of PC12 cells seeded on top of the composites. The viability of cells is also recorded under different in vitro conditions. The collective materials characterization and the results from the bioassays are used to explain the role of anisotropy on the radiosensitization of nanostructures containing Ga. The presence of Ga ions in composites can have a radiosensitizing effect, and the amount of the available Ga3+ determines the magnitude of the radiosensitization. The shape of the particles determines the stability in aqueous solutions and release of Ga3+ that triggers ROS production. The concentration and shape of Ga-containing materials can be combined to generate an additive effect by increasing the amount of available free metal ions in solution. The studies with GaOOH containing composites enable one to explore the role of key parameters that lead to an increased efficiency of radiation treatments.

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“…However, an increase in the hydrodynamic size distributions was observed due to the oxidation of LMNPs to form elliptical-shaped Ga oxide hydroxide (GaOOH) nanorods 48 h after production (Figure b). The oxidation of LMNPs is an alternative to conventional sol–gel technique for producing GaOOH nanorods with an organic coating . We discovered that the formation of oxide nanorods could be inhibited by passivating the LMNP surface with trisodium citrate antioxidant (Figure b), thereby significantly improving stability.…”

Section: Grafting Liquid Metal Particles With Polymersmentioning

confidence: 99%

Liquid Metal Particles and Polymers: A Soft–Soft System with Exciting Properties

Tang

Qiao

2021

Acc. Mater. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Gallium-based liquid metal alloys are a special type of material that is in the liquid state at (or near) room temperature. They are particularly attractive due to their unique combination of a fluidic and metallic body, together with a chemically reactive and functionable surface. As a fluid, liquid metals provide the best union of stretchability, deformability, and electrical conductivity among all soft materials. Such an advantage in combination with their low toxicity and relatively good biocompatibility have imparted liquid metals with unique features that can be harnessed for versatile applications in fields such as electronics, energy, chemistry, and biomedical research. More importantly, the fluidic nature of liquid metals allows them to be readily processed using shear for making particles with variable sizes (from nm to mm), which is not possible with solid materials. These particles have a liquid metal core−solid metal oxide shell (conductor−semiconductor) structure, allowing them to merge, transform shape, change phase, respond to stimuli, and self-heal. Despite these unique features, limited surface stability and functionality, unpredictable reactivity, and uncontrollable hydrophilicity of liquid metal particles niche their wider applications in biomedical fields. To bestow liquid metal particles with desirable surface properties while taking the benefits offered by soft features, another important soft materialpolymerscan be synthesized and engineered on an on-demand basis to coat or embed liquid metal particles. This leads to the formation of liquid metal−polymer soft composites with versatile surface properties. More specifically, polymer segments with corresponding functions for surface anchoring, tuning solubility, enhancing biocompatibility, providing stimuli-responsive properties, and further bioconjugation can be linked together, thereby forming macromolecules to graft liquid metal particles for yielding soft− soft systems with exciting properties. Herein, we provide a concise review of our contributions to the production, investigation, characterization, and application of liquid metal particle−polymer composites. First, we summarize various top-down techniques developed for producing micro-to nanosized liquid metal particles. We highlight two platforms we developed for tackling long-existing problems encountered by sonicationthe most widely adopted method for producing liquid metal particles. Second, we discuss the design of polymers for surface modification of particles. Various grafting strategies for polymers synthesized using different approaches are elaborated. We also discuss factors that affect the colloidal and chemical stability of the composite in biological buffers. Methods for further surface functionalization of the composite are presented, followed by providing examples of biomedical and sensing applications for the system. Next, we introduce the fabrication, unique properties, and applications of elastomeric hybrid composit...

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Study of Gallium Oxide Nanoparticles Conjugated with β-Cyclodextrin: An Application To Combat Cancer

Cited by 32 publications

References 36 publications

Gallium–Curcumin Nanoparticle Conjugates as an Antibacterial Agent against Pseudomonas aeruginosa: Synthesis and Characterization

Gallium–Curcumin Nanoparticle Conjugates as an Antibacterial Agent against Pseudomonas aeruginosa: Synthesis and Characterization

Ga Ion-Enhanced and Particle Shape-Dependent Generation of Reactive Oxygen Species in X-ray-Irradiated Composites

Liquid Metal Particles and Polymers: A Soft–Soft System with Exciting Properties

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