Study of gene expression alteration in male androgenetic alopecia: evidence of predominant molecular signalling pathways

Abstract

This study provides compelling evidence for distinct molecular events contributing to alopecia that may pave the way for new therapeutic approaches.

Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration

“…Several molecules secreted by mast cells could contribute to HF turnover, including histamine and serotonin which promote epidermal keratinocyte proliferation in situ [83]. Mast cell activity is also suspected to contribute to hair loss disorders, such as androgenic alopecia and cicatricial alopecia [84][85][86].…”

Serum androgens and prostate‐specific antigen levels in androgenetic alopecia: is there a difference between frontal and vertex baldness?

“…Androgenetic alopecia (AGA) is the most common form of hair loss in men. A distinct pattern of progressive hair loss, starting from the frontal area and the vertex of the scalp, is caused by a combination of genetic and hormonal factors …”

“…A distinct pattern of progressive hair loss, starting from the frontal area and the vertex of the scalp, is caused by a combination of genetic and hormonal factors. 1 A prevailing hypothesis that has been argued for over 20 years is that AGA, especially when it occurs in younger men, might be a marker of increased risk of prostate cancer (PCa) later in life. [2][3][4][5][6][7][8][9][10] Screening for early PCa is one of the most challenging and controversial issues in all of medicine.…”

Regulatory pathways implicated in male androgenetic alopecia pathogenesis

“…Overall, this study by Michel and colleagues has provided a transcriptome‐based validation of the established regulatory mechanisms involved in AGA and also introduced inflammation as a potentially implicated factor in AGA.…”

“…In this issue of the BJD , Michel and colleagues present their findings on the transcriptomic characteristics of hair follicles from individuals with androgenetic alopecia (AGA) . Although AGA development is established to be dependent on androgen and genetic predisposition (reviewed in Heilmann‐Heimbach et al …”