Study of glass transition phenomena in the supercooled liquid phase of methocarbamol, acetaminophen and mephenesin

Dielectric Spectroscopy in Ibuprofen-Dioxane Mixture

“…The inverse temperature dependence of peak loss frequency is described well by Arrhenius Eqn. (4), and the corresponding details are tabulated in Table 1. The…”

“…Before each dielectric scan, the dielectric cell was calibrated with benzene at room temperature. For details of the experimental setup, the reader may consult the earlier publications [4][5][6].…”

“…The study of vitrification transition phenomena has always been interested in hydrogen-bonded supercooled liquids composed of small molecules [1][2][3][4][5][6]. It is known for decades that several monohydroxy alcohols [7][8][9][10][11][12][13][14][15] and amides [16] hydrogen bonded glass forming systems results in intramolecular and intermolecular hydrogen bonding and behave differently.…”

Acetaminophen, Methocarbamol, Guaifenesin and Mephenesin in Propylene Glycol: Solubility and Phase Behaviour for Use in Medical Industry

“…The dielectric cell was then filled with the liquid mixture without entrapping air bubbles, and data were taken during cooling and heating cycles in the argon atmosphere. For further details of the experimental setup, the reader may consult the earlier publications from this laboratory [15,16]. Prior to each dielectric run, the dielectric cell was calibrated with benzene at room temperature.…”

“…For orally administered drugs solubility is the most important parameter. As discussed in a number of publications [10][11][12][13][14][15][16] improvement in the water solubility of pharmaceuticals improves drug absorption and hence bioavailability of the drugs. Therefore, solubility behavior of drugs in PG is useful for pharmaceutical dose design.…”