Study of haematological parameters in malaria

Surve, Ketaki Motram; Kulkarni, Anjali; Rathod, Santosh; Bindu, Rajan S

doi:10.18203/2320-6012.ijrms20172446

Cited by 12 publications

(23 citation statements)

References 9 publications

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“…In studies like Yadav RK et al, and Surve KM et al, had similar rates of male: female ratio which is 1.32:1 in both. 7,8 In other studies like Khuraiya P et al, and Patel G et al 9,10 also some near similar rates above studies which are 1.26: 1 and 1.30:1 respectively. Some studies showed very high incidence in males compared to females like Kalavati GP et al, showed a very high male incidence which is more than three times that of the female which is 3.38:1.…”

Section: Discussionsupporting

confidence: 66%

“…14 In Another study group Surve KM et al, fever was present in 99% of the patients. 8 But in all study groups, the predominant complaint is fever only. Along with fever, chills and rigors is also a common symptom observed in the majority of studies.…”

Section: Discussionmentioning

confidence: 88%

“…9,11,14 But in Surve KM et al, study group it was observed in only 64% of patients which showing lower incidence of chills and rigors when compared to this study. 8 It was also noted that 27% of the patients had easy fatiguability as their presenting complaint. There was no mention regarding this in any other studies.…”

Section: Discussionmentioning

confidence: 99%

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Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

et al. 2020

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Background: Malaria is a major health problem in many parts of India and some parts of Andhra Pradesh is one of the endemic areas for malaria. The objective was to study clinical profile and outcome of malaria in both species and mixed infection.Methods: Present study was carried out on 100 patients admitted during the period of November 2016 - October 2018 in Narayana medical college and hospital, Nellore. Malaria confirmed by Peripheral thick and thin smear or Antigen Assay underwent detailed clinical history and physical examination. This was followed by monitoring the outcome of the patients with respect to morbidity and mortality.Results: Out Of the 100 patients 58 patients were from rural background, males were predominant, most common age group was 20-30 (34%) followed by 31-40 (31%). Out of 100 patients, 54 patients were falciparum,44 patients had vivax and two had mixed infection. All of the patients had fever followed by chills and rigors (75%), nausea and vomiting (59%), easy fatiguability (28%), pain abdomen (17), cough (14%) in both infections, altered sensorium was seen in only falciparum (20.3%). On clinical examination,70% of the patients had pallor, splenomegaly in 46%, icterus (23%), hepatomegaly (14%) and pedal edema in12 patients were observed. All 0f the patients were treated with appropriate antimalarial drugs for appropriate duration, and all were recovered without any mortality.Conclusions:Malaria is very common disease in our country especially in South India, which is one of the endemic areas. Severe malaria usually caused by the falciparum more than vivax, early diagnosis and treatment decreases the mortality and morbidity.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 88%

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Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

et al. 2020

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“…Malaria could lead to changes in haematological status alongside with other conditions such as anaemia, thrombocytopenia and leukocytosis, leukopenia, lymphocytosis, monocytosis, eosinophilia and neutrophilia (23). Thrombocytopenia is among the major haematological aberrations frequently observed among malaria patients (24).…”

Section: Pathophysiology Of Malaria On Hematological Parameters Changmentioning

confidence: 99%

Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Asmerom

Yalew

Getaneh

2019

Preprint

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Background: Hematological changes are the most common complications encountered in malaria and they play a major role in malaria pathology. Hematological changes like red blood cells, platelets and leukocytes have been observed in patients with malaria. Therefore, this study aimed to compare hematological parameters of malaria infected adult patients in Alamata Hospital, Northeast Ethiopia from February 01- April 30, 2019. Methods: Comparative cross sectional study was used to compare the hematological parameters on a total of 238 study participants, consisting of 119 malaria infected patients and 119 malaria negative controls at Raya Alamata Hospital. Malaria diagnosis was done based on thick and thin blood films microscopy. Hematological parameters were determined by using an automated, DiRUi BCC/3000B hematology analyzer. Malaria parasite density was determined by counting the asexual parasites against 200 WBCs, and then calculated by using the standard formula. Data for the different hematological parameters were expressed as mean (±SD). Independent t-test was used for comparison the hematological parameters between the two groups. Binary logistic regression model was constructed for categorical dependent variables to see associations between predictors and outcomes. Results: In current study parameters like red blood cells count, hemoglobin, mean corpuscular volume, platelets count, and eosinophil counts were significantly lowered in malaria-infected patients than the controls. The prevalence of anemia and thrombocytopenia in malaria patients was 39.5% and 56.3%, respectively. Being female and malaria parasitaemia were found significantly associated with thrombocytopenia. The odds of developing thrombocytopenia with high malaria parasitaemia were 8.4 times more likely develop thrombocytopenia.Conclusion: Anemia and thrombocytopenia were the two common hematological abnormalities seen in malaria patients. The platelet count during malaria infection was inversely correlated with the parasitaemia. Malaria patients should be checked for the presence of hematological abnormalities such as anemia and have to be managed for those abnormalities. Keywords: Malaria, Malaria parasitaemia, Hematological parameters, Ethiopia

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“…Malaria surveillance for the period from 1995 to 2011 is shown that API (Annual parasite rate) has been steadily declining in India from 3.29 in 1995 to 1.10 in 2011 [2]. Malaria causing plasmodium are parasites of blood and hence induce haematological alterations [3]. The anaemia is caused by excess removal of non-parasitized erythrocytes in addition to immune destruction of parasitized red cells, and impaired compensation for this loss by bone marrow dysfunction [4,5].…”

Section: Introductionmentioning

confidence: 99%

Study of haematological parameters in malaria: a prospective study

Babariya¹,

Parmar²

2020

Trop J Pathol Microbiol

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Background: A blood parasites plasmodia is responsible for malaria hence there are haematological alterations in malaria. The haematological changes that have been reported to accompany malaria include anaemia, thrombocytopenia, leucocytosis and leucopenia. Methods: Total 585 smear positive malaria cases were taken and various haematological parameters were studied. Results: Out of 585 smear positive cases, P. vivax was positive in 422 (72%) cases, while P. falciparum was positive in 160 (27%) cases and mixed infection was found in 3 (1%) cases. Anaemia was seen in 420 (71.79%) cases. Normocytic normochromic blood picture was the most common type in anaemic patients 223 (38.11%). Next common finding was Normocytic hypochromic RBCs 185 (31.62%). Microcytic hypochromic RBCs found in 152 (25.98%) cases. Thrombocytopenia was seen in total 490 (83.76%) of the patients. Moderate thrombocytopenia was more common and present in 409 (70%) of patients while Severe thrombocytopenia was seen in 81 (13.84%) of cases. In falciparum malaria thrombocytopenia was present in 90% of the patients while it was present in 81.27% of the patients in vivax malaria. 129 cases (22.05%) shows leucopoenia out of which 81 (13.84%) belong to P. vivax, 45 (7.69%) belong to P. falciparum and 3 (1%) were belong to mixed infection. Total Leucocyte Count was normal in 77.95 % of the patients. Conclusions: Various haematological findings can help in early diagnosis of malaria which is essential for timely and appropriate treatment which can limit the morbidity and prevent further complications.

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Study of haematological parameters in malaria

Cited by 12 publications

References 9 publications

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

Clinical profile of falciparum, vivax and mixed infections of malaria, from a tertiary care hospital, Coastal Andhra, India

Hematological parameters of malaria infected adult patients in Raya Alamata Hospital, Northeast Ethiopia.

Study of haematological parameters in malaria: a prospective study

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