Study of heating curves generated by magnetite nanoparticles aiming application in magnetic hyperthermia

Abstract

Malignant tumors occur by uncontrolled multiplication of the body's cells. Currently, a promising technique, called magnetic hyperthermia, has been intensively researched. The technique makes it possible to interrupt the growth of tumor cells by the localized application of heat from the magnetization/demagnetization of magnetic nanoparticles (the Joule effect). The amount of heat generated depends on the magnetic material and the characteristics of the external magnetic field. In this work, magnetite Fe 3 O 4 particles (core-shell layer type) were synthesized by the wet coprecipitation method and coated with a polymer blend of polyethylene glycol and polyvinylpyrrolidone (PEG/PVP). The nanoparticles were subjected to a magnetic field of intensity equal to 12 kA m −1 and frequency 202 kHz. Under these conditions, specific absorption rate (SAR) values between 15-48 W g −1 were obtained. The heating curves obtained were adjusted with a proposed mathematical model. The adjustments were satisfactory and showed a good correlation coefficient (at an averaged level of 0.99). In addition, hysteresis curves and FTIR spectra were obtained. Keywords Magnetic hyperthermia • Nanoparticles • Magnetite • Mathematical model List of symbols I Electric current, [A] f Frequency, [kHz] t Magnetic field exposure time, [min] ΔT Temperature variation in the hyperthermia assay, [°C]

Investigating the specific absorption rate and antimicrobial activity of Mn0.25Fe2.75O4/Ag ferrogel based on carboxymethyl cellulose/polyvinyl alcohol composite polymer

“…This phenomena is showed in the graph as a line which is used to calculate the SAR-parameter. 59 The illustration of the adiabatic and the non-adiabatic as the ideal and actual processes correspondingly is exhibited in Figure 11.with m magnetite , m Ag , m CMC . m PVA , , and m water are Mn 0.25 Fe 2.75 O 4 mass, Ag, CMC, PVA, and water, respectively.…”

“…This phenomena is showed in the graph as a line which is used to calculate the SAR-parameter. 59 The illustration of the adiabatic and the non-adiabatic as the ideal and actual processes correspondingly is exhibited in Figure 11.…”

“…The thermal that generated from this relaxation mechanisms or caused by the hysteresis losses is reliant on the size, structure, and magnetic properties of the nanoparticles. 59 Moreover, the SAR value is related to the amount of the heat absorbed by the tissues that targeted by the sample, 62,63 so this also can be explained as the heat dissipation power per unit mass of the magnetic materials in the Mn 0.25 Fe 2.75 O 4 /Ag ferrogel that subjected to the AC magnetic field.…”

Preparation and Characterization of Zinc Ferrite and Gadolinium Iron Garnet Composite for Biomagnetic Applications

“…Their high surface-to-volume ratio [ 6 ] is responsible for their outstanding magnetic properties. In accordance with B. Issa et al [ 7 , 8 ], the primary characteristics that they must have to be used for biomedical applications are biocompatibility and non-toxicity; a particle size distribution between 10 and 200 nm [ 9 ]; a high saturation magnetization (M s ) to provide easy control of the particles in the blood through a moderate external magnetic field; and the possibility of better targeting of the pathologic tissue. By controlling the size, material, and coating of the MNPs, it is possible to improve and modify their properties considering the biomedical application in question.…”

Numerical Investigation of Ferrofluid Preparation during In-Vitro Culture of Cancer Therapy for Magnetic Nanoparticle Hyperthermia

“…The phenomenon of MF heating under the AC magnetic field is a complex physical effect, where the electromagnetic (EM) energy is converted to power dissipation induced via Brownian and Néel relaxation, and hysteresis losses (in large-sized MNPs) [ 39 , 40 , 41 ]. The induction heating of MNPs exposed to an applied magnetic field (AMF) is specified as the specific loss power (SLP), also called the specific absorption rate (SAR) [ 42 , 43 , 44 ], which is a quantity that evaluates the efficiency of nanoparticles in transforming EM energy into power. The SLP can be calculated by calorimetric and magnetic methods [ 7 , 45 , 46 ].…”