Study of High Blood Pressure and its Effect to Cancer

Abstract

Study of High Blood Pressure and its Effect to Cancer

Exploring the Impact of Allogeneic Gamma Delta T Cell Adoptive Transfer on HIV Replication in a Humanized Mouse Model

“…This research focuses on investigating the adoptive transfer of allogeneic γδ T cells and its impact on HIV replication within a humanized mouse model. Humanized mice, generated by engrafting immunodeficient mice with human hematopoietic stem cells, provide a valuable platform for studying human-specific immune responses in vivo [4]. The intricate interplay between allogeneic γδ T cells and HIV within this model system holds the key to understanding the potential risks and benefits associated with this novel immunotherapeutic strategy [5].…”

Progress in Humanized Mouse and Rat Models for Advancing HIV Research: Transitioning from Traditional Approaches to Innovative Strategies

“…These models have proven instrumental in studying critical aspects of HIV infection, such as viral entry, replication, latency, and the dynamics of the host immune response. They serve as invaluable tools for preclinical testing of antiretroviral drugs and other therapeutic strategies, facilitating a more accurate prediction of treatment outcomes before advancing to human clinical trials [7].…”

Navigating Unexplored Frontiers: Leveraging Gamma-Delta T Cells for the Control of Human Immunodeficiency Virus (HIV)

“…The relentless global battle against Human Immunodeficiency Virus (HIV) continues to underscore the urgent need for innovative therapeutic strategies that can complement existing antiretroviral treatments. In the pursuit of such breakthroughs, the immune system's intricate machinery, particularly the enigmatic gamma-delta (γδ) T cells, has emerged as a focal point of interest [1]. While conventional T cells have been extensively studied, the unique characteristics and potential therapeutic applications of γδ T cells remain underexplored, representing a reservoir of "unknown unknowns" in the quest for effective HIV control [2].…”