The inertial subrange scaling of the axial velocity component is examined for the centre line of turbulent pipe flow for Reynolds numbers in the range 249 Re λ 986. Estimates of the dissipation rate are made by both integration of the one-dimensional dissipation spectrum and the third-order moment of the structure function. In neither case does the non-dimensional dissipation rate asymptote to a constant; rather than decreasing, it increases indefinitely with Reynolds number. Complete similarity of the inertial range spectra is not evident: there is little support for K41, and effects of Reynolds number are not well represented by Kolmogorov's "extended similarity hypothesis", K62. The second-order moment of the structure function does not show a constant value, even when compensated by K62. When corrected for the effects of finite Reynolds number, the third-order moments of the structure function accurately support the " 4 5 ths" law, but they do not show a clear plateau. In common with recent work in grid turbulence, nonequilibrium effects can be represented by an heuristic scaling that includes a global Reynolds number as well as a local one. It is likely that nonequilibrium effects appear to be particular to the nature of the boundary conditions. Here, the principal effects of the boundary conditions appear through finite turbulent transport at the pipe centre line which constitutes a source or a sink at each wavenumber.