Study of Ischemia Modified Albumin as a Biomarker in Acute Ischaemic Stroke

Menon, Bindu; Ramalingam, K.; Krishna, Vamsi

doi:10.1159/000488188

Cited by 30 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, some studies showed that the levels of IMA may be diverse in different ischemic conditions such as stroke, mesenteric ischemia and different types of cancer. [9][10][11] We hypothesized that a newly developed practical and inexpensive method 'dynamic TD homeostasis' and IMA can be evaluated in the serum of patients with cervical cancer in conjunction with current diagnostic tests. Herein, our objective is to evaluate whether there is a difference between cervical cancer patients and healthy individuals by means of dynamic TD homeostasis, IMA and other oxidative stress parameters.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Thiol‐disulfide status of patients with cervical cancer

Sezgin

Kıncı

Pirinççi

et al. 2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

Aim: The evaluation of dynamic thiol-disulfide homeostasis among patients with the cancer of the uterine cervix. Methods: The study was conducted in 62 cervical cancer patients and 61 healthy women who had been followed up in an obstetrics and gynecology clinic between September 2018 and April 2020. Serum disulfide, native thiol, total thiol, ischemia modified-albumin, total antioxidant and oxidant capacities, and oxidative stress index values were measured in all participants. Results: The mean plasma disulfide levels of the cervical cancer group was statistically significantly higher than that of the control group (25.79 AE 6.90 μmol/L, 22.31 AE 6.11 μmol/L, respectively) (P = 0.004). Plasma native thiol and total thiol levels were lower in cervical cancer patients (299.27 AE 99.05 μmol/L and 350.86 AE 102.72 μmol/L, respectively) compared to controls, but no statistically significant difference was observed (318.00 AE 93.75 μmol/L and 376.44 AE 98.51 μmol/L, respectively) (P = 0.284, P = 0.161). With respect to the ischemia modified-albumin level, no statistically significant difference was observed between two groups. There were statistically significant positive association between disulfide level and both the stage of cervical cancer (r = 0.278, P = 0.029) and total oxidant capacity level (r = 0.256, P = 0.046). Conclusion: Dynamic thiol-disulfide homeostasis may participate in the pathophysiological mechanisms of cervical cancer and may be a potential biomarker for early identification of cervical cancer in future.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Ischemia modified‐albumin (IMA) is a biochemical test used in cases that may cause an acute ischemic condition such as acidosis, free radical damage and hypoxia. However, some studies showed that the levels of IMA may be diverse in different ischemic conditions such as stroke, mesenteric ischemia and different types of cancer 9–11 …”

Section: Introductionmentioning

confidence: 99%

Thiol‐disulfide status of patients with cervical cancer

Sezgin

Kıncı

Pirinççi

et al. 2020

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…Ischemia-modi ed albümin (IMA) is the altered form of albumin as a result of oxidative stress and is de ned as a new marker used in determining ischemic events [24]. Although IMA was rst de ned as a myocardial ischemic marker, studies have shown that it increases in non-cardiac oxidative stress and ischemia states, such as cerebrovascular diseases, in ammatory diseases, pulmonary embolism, and chronic liver diseases [24][25][26][27][28]. Besides, the thiol/disul de balance developed by Erel et al is used to evaluate the oxidant/antioxidant balance in oxidative damage [29].…”

Section: Introductionmentioning

confidence: 99%

Effect of Methylenetetrahydrofolate Reductase (MTHFR) gene mutations and oxidative stress in silent brain infarction

Koşar¹,

Tepebaşı²,

Şengeze³

et al. 2021

Preprint

View full text Add to dashboard Cite

Ischemic infarctions occur under the influence of genetic and environmental factors. In our study, the role of ischemia-modified albumin and thiol balance, which are new markers in determining oxidative damage together with MTHFR gene mutations and homocysteine levels, in the development of SBI was investigated. White matter lesions in the magnetic resonance imaging (MRI) results of the patients were evaluated according to the Fazekas scale and divided into groups (Grade 0, 1, 2, and 3). Homocysteine, folate, B12, IMA, total thiol, and native thiol were measured by biochemical methods. The mutations in MTHFR genes were investigated by the RT-PCR method. According to our results, a significant difference was found between the groups in age, homocysteine, folate, IMA, total thiol, and native thiol parameters (p<0.05). When we compared the groups in terms of genotypes of the C677T gene, we found a significant difference in TT genotype between grades 0/3 and 1/3 (p<0.05). We determined that homocysteine and IMA levels increased and folate levels decreased in CC/TT and CT/TT genotypes in the C677T gene (p<0.05). Considering our results, the observation of homocysteine and IMA changes at the genotype level of the MTHFR C677T gene and between the groups, and the deterioration of thiol balance between the groups suggested that these markers can be used in the diagnosis of silent brain infarction.

show abstract

“…IMA is accepted as a marker of oxidative stress, ischemia and endothelial disfunction. There are several recent studies that point to the relationship between IMA and infections, cardiovascular diseases and stroke . IMA levels have also been evaluated in some inflammatory and rheumatological diseases such as rheumatoid arthritis and Behçet's disease .…”

Section: Introductionmentioning

confidence: 99%

“…There are several recent studies that point to the relationship between IMA and infections, cardiovascular diseases and stroke. [14][15][16][17] IMA levels have also been evaluated in some inflammatory and rheumatological diseases such as rheumatoid arthritis and Behçet's disease. 18,19 The Birmingham Vasculitis Activity Score (BVAS) is a validated tool for assessment of disease activity in patients with many different forms of vasculitis.…”

Section: Introductionmentioning

confidence: 99%

Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch‐Schönlein purpura)

et al. 2019

View full text Add to dashboard Cite

Aim The aims of the study are to investigate serum neopterin and ischemia modified albumin (IMA) levels in patients with immunoglobulin A vasculitis (IgAV) and evaluate the association of these markers with disease activity and relapse. Method Thirty‐four consecutive adult patients (24 male and 10 female) admitted to the rheumatology clinic and met the IgAV American College of Rheumatology (ACR) criteria were enrolled in this cross‐sectional study. Demographic and clinical features of IgAV and a control group were recorded into a predefined protocol. Disease activity was categorized as “remission” or “active” according to Birmingham Vasculitis Activity Score (BVAS). BVAS ≥ 1 was accepted as "active". Serum neopterin levels, high‐sensitivity C‐reactive protein (hsCRP) and IMA were evaluated according to BVAS and compared to the healthy control group. Results Serum median (interquartile range) neopterin, IMA levels and hsCRP were higher in the study group than in control group (2.01 [12.5] ng/mL vs 1.77 [1.37] ng/mL, 0.67 [0.2] ng/mL vs. 0.43 [0.17] ng/mL, 5.6 [17.1] mg/L vs. 1.55 [1.6] mg/L, P = .095, P < .001 and P = .002, respectively). When evaluated according to BVAS, IMA and hsCRP levels were significantly higher in the group with active disease (0.77 [0.12] vs 0.61 [0.13] and 14.85 [4.6], P = .009 and P = .03, respectively). Serum neopterin levels were significantly higher in the active group compared to BVAS (18.95 [32.36] vs 1.63 [1.48], P < .001). Conclusion Oxidative stress is important in IgAV pathogenesis. Roles of hsCRP, neopterin and IMA as potential markers of diagnosis and disease activity seem to be worth studying in future studies with larger study groups.

show abstract

Study of Ischemia Modified Albumin as a Biomarker in Acute Ischaemic Stroke

Cited by 30 publications

References 13 publications

Thiol‐disulfide status of patients with cervical cancer

Thiol‐disulfide status of patients with cervical cancer

Effect of Methylenetetrahydrofolate Reductase (MTHFR) gene mutations and oxidative stress in silent brain infarction

Serum neopterin and ischemia modified albumin levels are associated with the disease activity of adult immunoglobulin A vasculitis (Henoch‐Schönlein purpura)

Contact Info

Product

Resources

About