Study of magnesium, glycosylated hemoglobin and lipid profile in diabetic retinopathy

Kareem, Ishrat; Jaweed, Syed Abdul; Bardapurkar, Jayashree Suhas; Patil, V. P.

doi:10.1007/bf02894270

Cited by 47 publications

(36 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This can alter the activity of membrane bound sodium, potassium ATPase [21,22], which is involved in the maintenance of gradients of sodium and potassium and in glucose transport. Low levels of magnesium can reduce secretion of insulin by the pancreas [23].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Trace Elements in Diabetes Mellitus

Praveeena¹,

Pasula²,

K³

2013

JCDR

View full text Add to dashboard Cite

Introduction: Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide. Its related morbidity is due to its micro and macro angiopathic complications. Aim:The aim of this study was to measure and compare the serum levels of zinc and magnesium in normal individuals and in diabetic patients.Method: Analysis of minerals was done in plasma by using a Varian Spectra AA 220 model atomic absorption spectrophotometer. Result:Our observations showed a definite lowering of serum magnesium (p<0.001) and serum zinc levels (p<0.001) were significant in diabetic group. Conclusion:The cause of diabetic hypomagnesaemia is multifactorial. An altered metabolism, a poor glycaemic control and osmotic diuresis may be contributory factors. Decreased serum zinc levels in diabetes may be caused by an increase in urinary loss. These decreased levels of trace elements cause disturbances in glucose transport across cell membrane lead to insufficient formation and secretion of insulin by pancreas which compromise in the antioxidant defense mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Osmotic actions of glycosuria and hyperglycaemia may work together in causing hypomagnesaemia and hyperglycaemia per se alone, which are known to depress the net tubular reabsorption of magnesium in normal humans [22,24,25,27].…”

Section: Discussionmentioning

confidence: 99%

Trace Elements in Diabetes Mellitus

Praveeena¹,

Pasula²,

K³

2013

JCDR

View full text Add to dashboard Cite

show abstract

“…The osmotic action of glucosuria prevents the net tubular reabsorption of Mg (40). The connection between the loss of Mg and the occurrence of DM is supported by therapeutic findings on T2DM, which likely increase Mg levels.…”

Section: Scientificmentioning

confidence: 79%

Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

Moustafa¹

2016

Acta Facultatis Medicae Naissensis

View full text Add to dashboard Cite

SU M M A RYInsulin resistance and β-cell function impairment play a role in the pathogenesis of type 2 diabetes (T2DM). Insulin signaling is inhibited by fetuin-A, an abundant plasma protein. Fetuin-A is also a candidate marker of the T2DM risk. This case-control study aimed to determine whether fetuin-A serum level is related to insulin resistance, β-cell function impairment, and total and ionized Ca and Mg serum levels in Erbil patients with T2DM.A total of 60 patients with T2DM were recruited, and 30 healthy persons were included in the control group. Fetuin-A and insulin concentrations were measured through ELISA. Other biochemical parameters were determined spectrophotometrically. Insulin resistance (HOMA2IR), insulin sensitivity (HOMA2%S), and β-cell function were examined by using a homeostatic model assessment 2 (HOMA2).Fasting serum insulin, fetuin-A serum levels, and HOMA2IR were significantly increased. HOMA2%S of the patients with diabetes was significantly lower than that of the control group. The total serum and ionized Ca and Mg contents and the Ca/Mg ratio were reduced in the patients.Therefore, fetuin-A is related to T2DM pathogenesis and is strongly associated with insulin resistance and glycemic control in T2DM patients. Future large-scale studies are necessary to validate fetuin-A as an indicator of IR in T2DM patients.

show abstract

“…This association between diabetes mellitus and magnesium is said to have a wide range of impact on diabetic control and complications. (7,8) The present study was undertaken with an aim to estimate level of magnesium in patients with type 2 diabetic and to correlate the serum magnesium concentrations with HbA1C, blood sugar fasting, blood sugar post prandial, Serum Urea and Serum Creatinine with that of healthy control subjects.…”

Section: Introductionmentioning

confidence: 99%