Study of matrix‐induced effects in multi‐residue determination of pesticides by online gel permeation chromatography‐gas chromatography/mass spectrometry

Yu, Sha; Xu, Xia

doi:10.1002/rcm.6193

Cited by 30 publications

(10 citation statements)

References 53 publications

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“…Endogenous substances include salts, carbohydrates, amines, urea, lipids, peptides, and metabolites (Little, Wempe et al 2006; Sviridov and Hortin 2009; Ismaiel, Zhang et al 2010). Exogenous substances contributing to matrix effects include mobile phase additives such as trifluoroacetic acid (TFA) and buffer salts (Garcia 2005) plastic materials such as phthalates, and the commonly used anticoagulant, Li-heparin (Mei, Hsieh et al 2003; Yu and Xu 2012). …”

Section: Sources Of Matrix Effectsmentioning

confidence: 99%

“…While the mechanism has not yet been explained, co-eluted matrix components that contribute to such effects include phthalates, caffeine, aliphatic acids, alcohol, aldehydes, and sterols (Yu and Xu 2012). We hypothesize that these matrix components may compete with or suppress the ionization ability of analytes in the gas phase.…”

Section: Matrix Effects In Gas Chromatography-mass Spectrometrymentioning

confidence: 99%

See 1 more Smart Citation

Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring

Panuwet

Hunter

DʼSouza

et al. 2015

Critical Reviews in Analytical Chemistry

288

190

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The ability to quantify levels of target analytes in biological samples accurately and precisely, in biomonitoring, involves the use of highly sensitive and selective instrumentation such as tandem mass spectrometers and a thorough understanding of highly variable matrix effects. Typically, matrix effects are caused by co-eluting matrix components that alter the ionization of target analytes as well as the chromatographic response of target analytes, leading to reduced or increased sensitivity of the analysis. Thus, before the desired accuracy and precision standards of laboratory data are achieved, these effects must be characterized and controlled. Here we present our review and observations of matrix effects encountered during the validation and implementation of tandem mass spectrometry-based analytical methods. We also provide systematic, comprehensive laboratory strategies needed to control challenges posed by matrix effects in order to ensure delivery of the most accurate data for biomonitoring studies assessing exposure to environmental toxicants.

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Section: Sources Of Matrix Effectsmentioning

confidence: 99%

Section: Matrix Effects In Gas Chromatography-mass Spectrometrymentioning

confidence: 99%

Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring

Panuwet

Hunter

DʼSouza

et al. 2015

Critical Reviews in Analytical Chemistry

288

190

View full text Add to dashboard Cite

show abstract

“…Matrix effects, expressed as suppression or enhancement of instrument signals, have been generally recognized as an important and serious error source in the quantitative analysis of trace-level compounds in food samples by using either the GC-MS/MS or LC-MS/MS method. − In our previous trial on analysis flavorings in infant formula by LC-MS/MS, the matrix effects were discussed and verified by contrastive experiments. To correct matrix effects, a combination of isotope-labeled internal standards and matrix-matched calibration solutions was performed, and satisfactory results were obtained.…”

Section: Resultsmentioning

confidence: 99%

Determination of Four Flavorings in Infant Formula by Solid-Phase Extraction and Gas Chromatography–Tandem Mass Spectrometry

Shen

Chen

et al. 2014

J. Agric. Food Chem.

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Increasing attention has been focused on the artificial flavorings added in foods, especially those for infants and children. For the first time, a sensitive and efficient analytical method based on gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed for the simultaneous identification and quantification of four flavoring agents (vanillin, methylvanillin, ethylvanillin, and coumarin) in infant formula samples. The flavorings in samples were extracted with methanol/water (v/v, 1:1), cleaned up by solid-phase extraction, and determined by GC-MS/MS in selected reaction monitoring (SRM) mode. Both isotope-labeled internal standards and matrix-matched calibration solutions were used to correct the matrix effects. The limit of quantification (LOQ) was calculated as 10 times the standard deviation, and it was 10.0 μg kg (-1) for vanillin, methylvanillin, ethylvanillin, and coumarin. The average recoveries were in the range of 82.8-107.5% with relative standard deviations (RSDs) below 8.9% measured at three concentration levels (10, 50, and 100 μg kg(-1)). The proposed method is suitable for the sensitive and accurate simultaneous determination of four flavoring agents in infant formula samples and also provided potential use for reference in terms of real analysis of other foods.

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“…Gas chromatography − tandem mass spectrometry (GC-MS/MS) with multiple reaction monitoring (MRM) mode has been proven to be a powerful and widely used analytical technique for trace pesticides in all kinds of sample because of its high selectivity, precision, sensitivity and confirmation [24,25]. Matrix effects have been generally recognized as an important and serious error source in the quantitative analysis of trace-level compounds in food samples by using the GC-MS method [26]. The stable isotope dilution assay (SIDA) is a good way to solve the matrix effect [27].…”

Section: Introductionmentioning

confidence: 99%

Determination of anthraquinone in tea by stable isotope dilution assay-gas chromatography-tandem mass spectrometry

Xie¹,

Huang²,

Deng³

et al. 2020

SN Appl. Sci.

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The aim of this study was to develop an analytical method for the accurate determination of the anthraquinone residue in tea samples (Pu'er tea, oolong tea, green tea, and black tea) by stable isotope dilution assay-gas chromatographytandem mass spectrometry (SIDA-GC-MS/MS). Samples were purified by solid-phase extraction after extraction with n-hexane:acetone (1:1, v/v). The anthraquinone residue was then detected by selected reaction monitoring (SRM) in electron ionization mode. Anthraquinone-d8 was added in the tea sample extraction process to eliminate the matrix effect. The average recoveries were in the range of 84.2-98.1% at different spiked levels (0.02, 0.04 and 0.08 mg kg −1 ), and the relative standard deviations were below 9.7%. The limits of quantification, calculated as 10 times the standard deviation, was 0.02 mg kg −1 . The developed method is simple, rapid, and accurate to quantitate the concentration of anthraquinone residues in tea samples.

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Study of matrix‐induced effects in multi‐residue determination of pesticides by online gel permeation chromatography‐gas chromatography/mass spectrometry

Cited by 30 publications

References 53 publications

Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring

Biological Matrix Effects in Quantitative Tandem Mass Spectrometry-Based Analytical Methods: Advancing Biomonitoring

Determination of Four Flavorings in Infant Formula by Solid-Phase Extraction and Gas Chromatography–Tandem Mass Spectrometry

Determination of anthraquinone in tea by stable isotope dilution assay-gas chromatography-tandem mass spectrometry

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