Study of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory marker for diabetic nephropathy in type 2 diabetic patients

Abdallah, Ali Ibrahim; Abdelaziz, Ahmed Ateia; El-Sayed, El-Sayed El-Meghawry; Emran, Tarek M.

doi:10.21608/ejhm.2018.10137

Cited by 15 publications

(11 citation statements)

References 7 publications

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“…Because both PLR and NLR have previously been used as markers for inflammation 36,37 . Also, PLR, NLR, and SII are standard tests that are inexpensive and predictive indicators for diabetic patients 38–41 . As well as in diabetes, PLR, NLR, and SII levels are considered predictive and prognostic markers for metabolic diseases such as diabetes with complications 40–43 .…”

Section: Discussionmentioning

confidence: 99%

Assessment of the systemic immune‐inflammation index in type 2 diabetic patients with and without dry eye disease: A case‐control study

Alhalwani,

Jambi,

Borai

et al. 2024

Health Science Reports

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BackgroundThe inflammation plays a role in the pathophysiology of type‐2 diabetes progression, and the mechanism remains unclear. The systemic immune‐inflammation index (SII) is a novel inflammatory marker for type 2 diabetes patients and integrates multiple indicators in complete blood counts and routine blood tests.AimSince there is no international diagnostic standard for dry eye disease (DED), this study uses low‐cost inflammatory blood biomarkers to investigate the correlation between SII and DM2–DED and determine the diagnosis indices of other biomarkers in DM2–DED.MethodologyA case‐control retrospective analysis of totel patients n = 293 randomly selected and categorized into four groups: DED, DM2, DM2‐DED, and healthy subjects. Demographic and blood biomarker variables were classified as categorical and continuous variables. The platelet‐to‐lymphocyte ratio (PLR), lymphocytes‐to‐lymphocyte ratio, neutrophil‐to‐lymphocyte ratio (NLR), and SII were calculated platelet count multiply by NLR and analyzed for their correlation for all groups.ResultsFocusing on DM2‐DED patients was more common in females, 59.6%, than in males, 40.2%. The mean ages were 60.7 ± 11.85 years, a statistically significant difference with all groups. In the study group DM2‐DED, there was an increase in all blood markers compared to all remaining groups except PLR. Only neutrophil, hemoglobin A1c (HbA1c), and fasting blood sugar levels were statistically significant differences in DM2‐DED patients (p > 0.001, p < 0.001, and p < 0.001, respectively) compared to all groups. There was a positive correlation between HbA1c and PLR, HbA1c and NLR, and HbA1c and SII (r = 0.037, p = 0.705; r = 0.031, p = 0.754; and r = 0.066, p < 0.501, respectively) in the DM2‐DED group.ConclusionThis study demonstrated that elevated SII values were linked to elevated HbA1c in DM2‐DED patients. The potential of SII and HbA1c as early diagnostic indicators for ocular problems associated with diabetes mellitus is highlighted by their favorable connection in diagnosing DM2‐DED.

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Section: Discussionmentioning

confidence: 99%

Assessment of the systemic immune‐inflammation index in type 2 diabetic patients with and without dry eye disease: A case‐control study

Alhalwani,

Jambi,

Borai

et al. 2024

Health Science Reports

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“…The inflammatory markers may cause insulin resistance by inhibiting β-cell function and by accelerating apoptosis. 3,4 these markers is not done routinely and is costly. Therefore, NLR and PLR have emerged as a novel surrogate markers.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, NLR and PLR have emerged as a novel surrogate markers. 3,4 Turkmen et al, reported the platelet involvement in atherosclerosis by secreting proinflammatory cytokines. 9 However, platelets releases thromboxanes, which may exacerbate inflammation in patients with elevated platelet count.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of neutrophil and platelet-to-lymphocyte ratio as inflammatory markers in type 2 diabetes mellitus patients

et al. 2023

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Background: Diabetes mellitus (DM), metabolic disease, and its prevalence are increasing in India. DM causes micro- and macrovascular complications. Inflammation is one of the contributing factor in the pathophysiology of DM. Aims and Objectives: This study aimed to evaluate neutrophil and platelet-to-lymphocyte ratio (PLR) in T2DM patients. Materials and Methods: This study was carried out in Biochemistry Department, Lt. B.R.K.M Government Medical College, Chhattisgarh, India. In this study, 150 type 2 DM patients were considered as cases and 150 normal subjects were considered as controls. Baseline data was collected from subjects. All subjects underwent physical and clinical examination. Fasting and post prandial venous blood samples were collected. FBS, PPBS, renal profile (urea, creatinine and uric acid) were estimated in serum sample. EDTA samples were used for complete blood count (CBC). Neutrophil-to-lymphocyte ratio (NLR) and PLR ratio were calculated from CBC values. HbA1c was estimated using whole blood sample. Blood pressure and BMI were recorded. Results: In this study, mean age of 61.2±4.0 years, systolic blood pressure 136.2±14.4 mmHg, diastolic blood pressure 100.1±12.5 mmHg, BMI 28.1±2.6 (kg/m2), FBS 180.7±22.3 mg/dL, PPBS 289.3±33.2 mg/dL, HbA1c 8.1±0.7%, serum urea 39.1±8.3 mg/dL, creatinine 1.1±0.2 mg/dL, uric acid 7.1±2.0 mg/dL, lymphocytes 18.3±3.0%, NLR 8.1±3.1, and PLR 20.3±7.1 were significantly increased in cases than controls. Conclusion: Elevated ratios of NLR and PLR may serve as markers of inflammation in T2DM. These are inexpensive and helpful to assess the inflammatory status in T2DM.

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“…Recent data indicate that MPVLR, calculated from blood counts, is associated with a risk of developing chronic micro- and macrovascular diabetic complications [ 31 , 32 ]. The importance of NLR and PLR in the development of microvascular complications [ 33 ] as predictive and prognostic markers in the development of diabetic nephropathy and retinopathy has also been emphasised [ 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Dietary Intake of Polyphenols or Polyunsaturated Fatty Acids and Its Relationship with Metabolic and Inflammatory State in Patients with Type 2 Diabetes Mellitus

et al. 2022

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Background: The aim of the study was to evaluate the relationship between polyphenol or polyunsaturated fatty acids (PUFAs) consumption and the selected metabolic and inflammatory markers in type 2 diabetes (T2DM) patients. Methods: The study enrolled 129 diabetics (49 men, mean age 64.1 ± 9.8 years) with different amounts of polyphenol and PUFAs consumption. Results: A significant effect of polyphenol or PUFAs omega-3 consumption on fasting glucose concentration (FG) or glycated haemoglobin fraction (HbA1c) was reported. A negative association was observed between FG and total polyphenol, flavonoid, flavan-3-ol and stilbene intake. In the group with high flavonoid intake, the FG was significantly lower compared to the group characterised by low flavonoid intake. Polyphenols, except stilbenes, did not modulate HbA1c. Additionally, higher consumption of PUFAs omega-3 significantly decreased HbA1c, and the intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids negatively and significantly correlated with FG and HbA1c. Further analysis confirmed a significant association between EPA + DHA intake and HbA1c, with significant interactions with age and gender or with body mass index and waist-to-hip ratio. The dietary intake of polyphenols or PUFAs was independent of familial diabetes or diabetic diet application. Conclusions: Our study indicates a positive effect of high consumption of flavonoids, omega-3 PUFAs and stilbenes on the markers of carbohydrate metabolism balance and the absence of such an effect on other cardiometabolic markers and inflammatory conditions.

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Study of neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) as a predictor inflammatory marker for diabetic nephropathy in type 2 diabetic patients

Cited by 15 publications

References 7 publications

Assessment of the systemic immune‐inflammation index in type 2 diabetic patients with and without dry eye disease: A case‐control study

Assessment of the systemic immune‐inflammation index in type 2 diabetic patients with and without dry eye disease: A case‐control study

Assessment of neutrophil and platelet-to-lymphocyte ratio as inflammatory markers in type 2 diabetes mellitus patients

Dietary Intake of Polyphenols or Polyunsaturated Fatty Acids and Its Relationship with Metabolic and Inflammatory State in Patients with Type 2 Diabetes Mellitus

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