Study of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Hypertensives and Normotensives

Abstract

Background and Aim: Long-term hypertension proceed to development of atherothrombotic disease and it's a major healthcare problem worldwide. Platelets and neutrophils play an important role in Cardiovascular (CV) events and development of atherothrombotic disease. Recently, Neutrophil/lymphocyte Ratio (NLR) and Platelet/lymphocyte Ratio (PLR), which can be easily calculated from the differential blood count, have been proposed as novel systemic inflammation-based markers predictive of thrombotic events. The aim of the present study was to explore the association between NLR and PLR with hypertension and as an indicator of cardiovascular risk. Methods: It's a cross sectional study. 50 Hypertensive patients aged 40-60 years, males and females with the history of Previously diagnosed hypertension >1 year duration or taking anti-hypertensive medications with blood pressure Systolic BP > 140 mm Hg, Diastolic BP > 90 mmHg were taken as study group. 50 normotensives aged 40-60, males and females with Systolic BP < 140 mmHg, Diastolic BP < 90 mmHg were taken as control group, who were matching socioeconomically with study group. A detailed history and physiological parameters were taken. Blood pressure was measured via auscultatory method using sphygmomanometer. Under aseptic precautions, 3 ml of venous blood samples were collected and analysed. Results: Neutrophil to Lymphocyte Ratio (NLR) was significantly higher (p<0.01) in study group. Platelet to Lymphocyte Ratio (PLR) was also higher in study group but statistically not significant (p>0.05). Conclusion: Hypertensives with higher NLR have greater risk for athero-thrombotic and atherosclerotic events.

Pathogenesis of hematological parameters in hypertension

“…Although the platelet-to-lymphocyte ratio (PLR) was found to be higher in a study group of hypertensive patients, the difference was not statistically significant [62]. A study conducted by Bayrakci et al [63] indicated that a high PLR in individuals with hypertension might suggest an increased risk of atherosclerosis, and this could potentially have predictive value in the future.…”

“…Additionally, larger-scale studies should be used to clarify how antihypertensive medication types affect NLRs [61]. Likewise, higher NLR hypertensives have been shown to be more susceptible to atherothrombotic and atherosclerotic events [62].…”

A cross-sectional study of neutrophil to lymphocyte ratio as a reliable inflammatory index among hypertensives in Government Rajaji Hospital, Madurai

“…Hypertension is a major risk factor to the development of atherothrombosis which is responsible for about 25% of deaths worldwide. 1 Neutrophils and platelets play a major and significant role in the development of atherothrombosis leading to fatal cardiovascular and cerebrovascular events. Presently, neutrophil lymphocyte ratio and platelet lymphocyte ratio which can be easily calculated from complete blood count have been identified as novel systemic inflammation-based indices predictive of cardiovascular risk.…”