Study of polyvinyl alcohol nanofibrous membrane by electrospinning as a magnetic nanoparticle delivery approach

Abstract

Electrospinning technique was used to fabricate polyvinyl alcohol (PVA)-based magnetic biodegradable nanofibers. PVA solution was mixed with ferrofluid or magnetic nanoparticles (MNPs) powder and formed two individual nanofibrous membranes (PVA/ferrofluid and PVA/MNPs powder) by electrospinning. The surface morphology of the nanofibrous membrane was characterized by scanning electron microscopy and the magnetic properties were measured by vibrating sample magnetometer. Macrophages (RAW 264.7) were co-cultured with the nanofibrous membranes for 12, 24, and 48 h and exhibited good cell viability (>95%). Results showed that the PVA fibers would be degraded and the embedded Fe3O4 nanoparticles would be released and delivered to cells.

Compare Analysis for the Nanotoxicity Effects of Different Amounts of Endocytic Iron Oxide Nanoparticles at Single Cell Level

“…Nanoparticles (NPs) have raised a broad interest in the field of material science or medicine [1] , [2] , [3] , [4] . Due to the larger surface area of NPs which increase the interactions between NPs and cell membrane, the internalization of NPs by cells is effective and which is attractive for delivering drugs, probes or proteins [5] , [6] , [7] . Among the NPs, magnetic iron oxide NPs are considered highly biocompatible and commonly used for biomedical applications as magnetic resonance imaging (MRI) contrast agents [8] , [9] , to magnetically label the cells for cell separation [10] and cell sorting [11] or as heat generators for magnetic hyperthermia (MH) [12] , [13] .…”

Machine learning-guided morphological property prediction of 2D electrospun scaffolds: the effect of polymer chemical composition and processing parameters

“…The jet solidies and collects on a grounded target in the form of nanobers. 12,13 The electrospun scaffolds possess a suitable surface for cell attachment due to a high surface area-to-volume ratio, high porosity, nano-topography, and close imitation of the natural ECM. 14,15 Electroconductive scaffolds are one of the most promising types of scaffolds, due to their electrical conductivity, which is a prerequisite for some tissues such as neural, cardiac, and muscle.…”

“…The jet solidifies and collects on a grounded target in the form of nanofibers. 12,13 The electrospun scaffolds possess a suitable surface for cell attachment due to a high surface area-to-volume ratio, high porosity, nano-topography, and close imitation of the natural ECM. 14,15…”

Magnetorheological behaviour and electrospinning of poly(ethylene oxide) suspensions with magnetic nanoparticles

“…At present, there are in principle two immediate basic ways to improve preparation and MR properties within a suspension. First, the 'classical' carrier liquids -such as Newtonian oils -are substituted by various polymers, and second, magnetic particles are coated (core-shell structures) by materials which contribute to reduced sedimentation under service of the corresponding suspensions (Bagheri et al, 2014;Cavaliere et al, 2010;Ger et al, 2014;Guo et al, 2009;Hong et al, 2013;Kannarkat et al, 2010;Khalil et al, 2013;Kim et al, 2013Kim et al, , 2014Li et al, 2013;Mrlik et al, 2013;Savva et al, 2014;Shahrivar and de Vicente, 2014;Sim et al, 2013;Singh et al, 2014;Sung et al, 2012;Ziyadi et al, 2014).…”