Study of Predictive Value of Pediatric Risk of Mortality (PRISM) Score in Children with End Stage Liver Disease and Fulminant Hepatic Failure

El‐Karaksy, Hanaa; El-Shabrawi, Mortada; Mohsen, Nabil; El-Koofy, Nehal; El-Akel, Wafaa; Fahmy, Mona; Yassin, Noha A.

doi:10.1007/s12098-010-0267-y

Cited by 9 publications

(5 citation statements)

References 11 publications

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“…Hasan ZE, et al 21 concluded that a PRISM-III score >8 was a significant predictor of mortality with an odd's ratio of 9.28 for mortality. An Egyptian study 22 done in patients with end stage liver disease and fulminant hepatic failure also got a PRISM cut-off score of 9.5.…”

Section: Discussionmentioning

confidence: 99%

Comparison between paediatric risk of mortality III and paediatric logistic organ dysfunction-2 as mortality predictor in paediatric intensive care

Shenoy¹,

Patil²,

Karunakar³

et al. 2023

Sri Lanka J Child Health

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Background: Scoring systems in an intensive care unit (ICU) help in monitoring the patient, evaluating the performance of the ICU and in determining the prognosis of the patient. Pediatric Logistic Organ Dysfunction-2 (PELOD-2) is a new scoring system describing organ dysfunction in paediatric intensive care unit (PICU) which has gained importance as a mortality predictor.Objectives: To assess the performance of PELOD-2 in predicting mortality and compare it with Pediatric Risk of Mortality-III (PRISM-III) scoring system.Method: This prospective observational study was carried out in a tertiary care PICU. All consecutive patients with critical illness were scored according to the 2 scoring systems within 24 hours of admission and followed up until discharge or death. Patients admitted for post-surgical care, PICU stay less than 2 hours, death within 8 hours of admission and patients leaving against medical advice were excluded from the study.Results: A total of 550 patients with critical illness was included in study with a median (IQR) age of 60 (12,132) months and a M: F ratio of 1.6. Predicted mortality using PELOD-2 and PRISM-III score was 62 and 63 patients respectively whereas actual mortality was 67 patients. Area under the ROC was 0.992 for PELOD-2 and 0.98 for PRISM-III with a mean difference of 0.0118 with 95% CI (0.00325 to 0.0204) p value of 0.007. Hosmer and Lemeshow goodness of fit test also showed good calibration in predicting mortality for both scoring systems (PELOD-2: ꭓ 2 = 6.051, p value of 0.301, PRISM-III -ꭓ 2 = 9.391, p value= 0.153

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Section: Discussionmentioning

confidence: 99%

Comparison between paediatric risk of mortality III and paediatric logistic organ dysfunction-2 as mortality predictor in paediatric intensive care

Shenoy¹,

Patil²,

Karunakar³

et al. 2023

Sri Lanka J Child Health

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“…In their study also, the observed mortality was significantly higher to PRISM score based expected mortality. The prospective study done on 30 patients with ESLD (End Stage Liver Disease) and FHF (Fulminant Hepatic Failure) by El-Karaksy et al [13] in Egypt have reported mortality of 56.7%. In their study PRISM score was calculated within 24 hrs of admission to PICU and outcome was recorded as deceased or survivors.…”

Section: Discussionmentioning

confidence: 99%

Use of PRISM III scoring for mortality prediction in a tertiary care centre of Rohilkhand region

Chauhan¹,

Kumar²,

Jaiswal³

2022

Int. J. Paediatrics Geriatrics

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Objective: Paediatric Risk of Mortality (PRISM III) score is a frequently used, physiologically based severity of illness measure, commonly used to control for severity of illness. It is significantly associated with morbidity and mortality and could be used to simultaneously estimate morbidity and mortality risk within the first 24 hours of admission in PICU. Predicting the outcome of any serious illness is of utmost importance for the planning and assessment of interventions in the health-care system, as well as for providing a prognosis for individual cases to the caregivers. Therefore, this study intends to evaluate the efficacy of PRISM III score in prediction of disease specific mortality rate in PICU. Methods: In this prospective, hospital based observational study, 107 children fulfilled the required criteria and were enrolled. PRISM III score was calculated using variables in the first 24 hours after admission. Outcome was noted as survivors and non-survivors. Results: A total of 107 patients were enrolled in the study. Out of 107 patients, 27 were non-survivors, with the mortality rate of 25%. The median PRISM III score was not found to be significantly different between survivors and non-survivors but the use of PRISM III score along with the need of mechanical ventilation and ionotropic support in the first 24 hrs of admission significantly predicted mortality. Overall, PRISM III score did help in severity assessment at the time of admission and the need of mechanical ventilation and ionotropic support. Conclusion:In patients with hepatobiliary and CNS dysfunction PRISM III -24 score could not predict mortality but it can be applied for severity assessment at the time of admission to PICU. PRISM III-24 score proved to be a good predictor of mortality for children admitted with septicaemia, nephrology, respiratory dysfunction.

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“…Also, the duration of this phase may be for many years and acute Hepatitis B is often unrecognized in children younger than five years old. Clinical acute Hepatitis B is more frequent in adults than children and probability of becoming chronic carrier of Hepatitis B is greater in children than adults [8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Assessment of factors affecting and causing Hepatitis B in Balochistan-Pakistan

Ullah¹

2020

PAB

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Hepatitis B infection caused by HBV is transmitted through HBV contaminated blood and body fluids, is a major communicable disease of vertical transmission. HBV infection is endemic in Asia pacific regions including Pakistan. The main objective of this study was to determine most common factors affecting and causing Hepatitis B. A cross sectional research study was conducted where blood samples were taken from suspected Hepatitis B individuals for diagnosis and confirmation of HBV. Social and demographical factors were studied with the help of questionnaire. Hepatitis B disease is promoted through sharing of equipment and environment with HBV infected individuals. Smoking either active or passive was significantly positively correlated with Hepatitis B disease whereas education and socioeconomic status were negatively correlated with Hepatitis B. The study conclude that unhygienic practices particularly in dental clinics substantially increase the risk of Hepatitis B. The present study serves as a primary data and will be helpful in future research on Hepatitis B in Balochistan.

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Study of Predictive Value of Pediatric Risk of Mortality (PRISM) Score in Children with End Stage Liver Disease and Fulminant Hepatic Failure

Abstract: PRISM score can be applied with an adequate degree of accuracy for severity assessment and mortality prediction to pediatric patients with ESLD or FHF.

Cited by 9 publications

References 11 publications

Comparison between paediatric risk of mortality III and paediatric logistic organ dysfunction-2 as mortality predictor in paediatric intensive care

Comparison between paediatric risk of mortality III and paediatric logistic organ dysfunction-2 as mortality predictor in paediatric intensive care

Use of PRISM III scoring for mortality prediction in a tertiary care centre of Rohilkhand region

Assessment of factors affecting and causing Hepatitis B in Balochistan-Pakistan

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