Study of prevalence of end-stage renal disease in Assiut governorate, upper Egypt

El-Arbagy, Ahmed R; Yassin, Yassin S; Boshra, Boules N

doi:10.4103/1110-2098.192441

Cited by 16 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Egypt, ESRD has been estimated to affect 264 to 414 per million population [15]. Despite the availability of a number of reports on opportunistic parasitoses among HD patients in Egypt [16–18], there is a paucity of data on the association of CD4+ counts with such infections.…”

Section: Introductionmentioning

confidence: 99%

Opportunistic parasitoses among Egyptian hemodialysis patients in relation to CD4+ T-cell counts: a comparative study

2019

View full text Add to dashboard Cite

Background Some reports are available on the prevalence of opportunistic parasitoses among hemodialysis (HD) patients, yet there is a paucity of data on the association of CD4+ T-cell counts with such infections. Therefore, this study aimed to determine the prevalence of intestinal parasites and Toxoplasma gondii in relation to CD4+ counts among HD patients in Alexandria, Egypt. Methods A comparative cross-sectional study was conducted on 120 HD patients and 100 apparently healthy individuals between December 2014 and January 2016. Data and samples (stool and blood) were collected from the participants after obtaining their informed consent. Stool samples were examined for parasites after concentration and staining, EDTA-blood samples were used for CD4+ counting by flow cytometry, and sera were analyzed for anti- Toxoplasma IgM and IgG antibodies. Results A significantly higher prevalence rate of intestinal parasitoses was found among HD patients compared to apparently healthy individuals (52.5% vs. 12.0%, respectively), with absence of helminths. Cryptosporidium species (32.5%), B. hominis (24.2%) and microsporidia (11.7%) were the most frequent parasites among HD patients, while B. hominis (13.0%), Cryptosporidium species (11.0%) and G. lamblia (4.0%) were the most frequent parasites among their counterparts. Statistically significant differences in parasite infection rates between patients and their counterparts were found for Cryptosporidium species, B. hominis and microsporidia. However, parasite species were not significantly associated with diarrhea. On the other hand, the overall T. gondii seroprevalence rate among HD patients was significantly higher than that among their counterparts (33.3% vs. 8%, respectively). HD patients with CD4+ counts < 200 cells/μl were twice more exposed to intestinal parasitoses compared to those with counts ≥200 cells/μl, but the difference was not statistically significant. However, low CD4+ counts were significantly associated with higher rates of Cryptosporidium species, microsporidia and T. gondii . Conclusions Intestinal parasitoses and T. gondii infection rates are significantly higher among Egyptian HD patients compared to apparently healthy individuals, with Cryptosporidium species, B. hominis , microsporidia and T. gondii being the most frequent parasites. CD4+ counts < 200 cells/μl are significantly associated with Cryptosporidium species, microsporidia and T. gondii among HD patients. ...

show abstract

Section: Introductionmentioning

confidence: 99%

Opportunistic parasitoses among Egyptian hemodialysis patients in relation to CD4+ T-cell counts: a comparative study

2019

View full text Add to dashboard Cite

show abstract

“…In Assiut, El-Arbagy et al, 2016, found that ESRD resulted from unknown reasons and was prevalent in 25% of patients (the highest proportion) [23]. That might be because of an environmental factor(s), for example, physical (harmful rays), chemical (heavy metals, dyes, and hydrocarbons), biological (viral infection), genetic (chromosomal abnormality), and nutritional factors, such as deficiency of one or more vitamins or minerals, undiagnosed chronic HTN or inefficient control, and lack of awareness among the treating physicians of the proper time frame for a referral [23]. The second cause of ESRD was HTN (21.4%), followed by DM (14.9%), prevalent in 13.5% of patients [23].…”

Section: Discussionmentioning

confidence: 99%

“…That might be because of an environmental factor(s), for example, physical (harmful rays), chemical (heavy metals, dyes, and hydrocarbons), biological (viral infection), genetic (chromosomal abnormality), and nutritional factors, such as deficiency of one or more vitamins or minerals, undiagnosed chronic HTN or inefficient control, and lack of awareness among the treating physicians of the proper time frame for a referral [23]. The second cause of ESRD was HTN (21.4%), followed by DM (14.9%), prevalent in 13.5% of patients [23].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of End-Stage Renal Disease in Fayoum governorate (Egypt)

Zekry

Mashahit

Soud

et al. 2023

Fayoum University Medical Journal

View full text Add to dashboard Cite

Introduction: Chronic kidney disease represents a common health burden in Egypt and worldwide. Hemodialysis remains the main renal replacement modality in spite of the advent of kidney transplantation. Identification of the risk factors is the first line to control disease spread and decrease its prevalence. Aim of the work:To evaluate the main causes and risk factors for end-stage renal disease (ESRD) among the Egyptian population Subjects and Methods: This cross-sectional study was held on 1000 HD after the exclusion of patients below 18 or above 60 and residents outside the Fayoum governorate. Patients were recruited from Fayoum governmental hospitals and Fayoum university hospital, Egypt. Data were collected from patient medical records, and missed data were collected from the patients or their relatives.Results: Mean age of the included patients was 49±10.1 years. Most patients in the current study were males (68.5%) and nonsmokers. ESRD was caused by hypertension (HTN) (46.1%), Kidney stones (25.4%), unknown causes (10.3%), and a combination of HTN and diabetes mellitus (DM) (6.8%). There were statistically significant differences between males and females regarding the frequency of some original kidney diseases. There were no statistically significant effects of working on the frequency of different kidney diseases. Conclusion: HTN, followed by Kidney stones, was the commonest cause of ESRD among HD patients in Fayoum. Future epidemiological studies should be conducted to investigate the unknown causes of ESRD.

show abstract

“…Impairment of renal function leads to a host of maladaptive changes, including fluid retention (extracellular volume overload), anaemia, and disturbances of bone and mineral density, hyperlipidaemia ,and malnutrition 4 . In Egypt, the predictable annual incidence of ESRD was around 74 per million and the total prevalence of patients on dialysis is 264 per million 5 .The prevalence of dialysis patients is supposed to be increasing and the main causes of ESRD in Egypt are not limited to diabetic nephropathy but also include hypertensive kidney disease, chronic glomerulonephritis(GN),chronic pyelonephritis, and obstructive uropathy 6 . Oxidative stress is known to be involved in many pathological processes, such as hypertension, atherosclerosis ,and neurological disorders with much evidences that CKD is also associated with increased oxidant production and decreased antioxidant protection 7 .…”

Section: Introductionmentioning

confidence: 99%

Relation between Hemodialysis and Oxidative Stress Markers’ blood levels in End Stage Renal Disease on Regular Dialysis

Hossam Arafat,

Safwat Elaraby,

Wahid Elsaid

et al. 2023

The Egyptian Journal of Geriatrics and Gerontology

View full text Add to dashboard Cite

Background: Chronic kidney disease (CKD) is a common medical problem in elderly. The progressive worsening of renal function in CKD induces numerous biological and clinical dysfunctions including augmentation of synthesis of inflammation and oxidative stress mediators. Aim of the Work:The aim was to study relation between frequency of hemodialysis and oxidative stress markers' blood levels in end stage renal disease (ESRD) patients on regular dialysis. Patients and Methods: This is a cross-sectional study that was done on a convenience sample of 80 cases of elderly patients,60years and older, who had ESRD and on regular dialysis. The study was conducted in the hemodialysis unit at Ain Shams University Hospital (El-Demerdash).The study period was from the first of May 2021to the end ofNovember2021. Results: We found a statistically significant positive correlation between hemodialysis related factors, namely duration of hemodialysis, number of sessions, and duration of each session and the blood levels of oxidative stress markers. Conclusion:Patients with ESRD on regular hemodialysis are at increased risk of oxidative stress risks as they are shown to have higher oxidative stress biological markers which are directly related to duration of being on hemodialysis, number of hemodialysis sessions and the duration of each session.

show abstract

Study of prevalence of end-stage renal disease in Assiut governorate, upper Egypt

Cited by 16 publications

References 0 publications

Opportunistic parasitoses among Egyptian hemodialysis patients in relation to CD4+ T-cell counts: a comparative study

Opportunistic parasitoses among Egyptian hemodialysis patients in relation to CD4+ T-cell counts: a comparative study

Epidemiology of End-Stage Renal Disease in Fayoum governorate (Egypt)

Relation between Hemodialysis and Oxidative Stress Markers’ blood levels in End Stage Renal Disease on Regular Dialysis

Contact Info

Product

Resources

About