Study of Renal Profile in Babies with Perinatal Asphyxia in a Tertiary Care Hospital: A Prospective Case Control Study

Roy, Banasree; Mondal, Gobinda

doi:10.3126/jnps.v33i3.8385

Cited by 3 publications

(5 citation statements)

References 16 publications

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“…In this study, 36 (60%) of 60 asphyxiated babies were hyponatremic. In the current investigation, hyponatremia was the most common electrolyte anomaly, which was consistent with the findings of Roy et al 18 Hypernatremia is most common in extremely preterm infants due to high transepidermal water loss, which may be exacerbated by excessive sodium administration. The current investigation excluded extremely preterm newborns.…”

Section: Discussionsupporting

confidence: 92%

“…This pattern of hyperkalemia among moderate and severe case group members matched earlier research findings. 18,19 Only 1.6% of participants in the control group developed hyperkalemia, compared to 18.3% of people in the case group. Blood urea and serum creatinine were considerably higher among case study participants among the various serum electrolyte mean values.…”

Section: Discussionmentioning

confidence: 93%

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Electrolyte abnormalities in patients with perinatal asphyxia

Prodhan

Azad²,

Shormin³

et al. 2022

Int J Contemp Pediatr

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Background: Perinatal hypoxia is still a major cause of death and disability in developing countries. The infant mortality rate fell from 92 per 1000 live births in 1991 to 43 per 1000 live births in 2011. The aim of the study was to study the electrolyte abnormalities in perinatal asphyxia cases.Methods: This cross-sectional descriptive study was conducted at the Department of Obstetrics and Pediatrics, Rangpur Medical College, and Hospital, Rangpur, Bangladesh. The study duration was 2 years, from January 2012 to December 2013. The study was conducted with a total of 120 neonates admitted in the neonatal ward of the study hospital, among which, 60 neonates who had perinatal asphyxia were selected for the case group, and the remaining 60 were age and gender-matched control group participants.Results: In 70% of cases, the mother was Primipara. Among the neonates, 61.67% were male, and 38.33% were female. Only 33% of the case neonates had received regular antenatal check-ups, while 55% had irregular check-ups, and 11.67% had no antenatal checkups. According to the grading of asphyxia, 51.67% of neonates had moderate asphyxia, 20% had mild asphyxia, and 28.33% had severe asphyxia. The comparison of mean values between the case, and control groups showed that both blood urea, and serum creatinine levels were significantly higher among the case group participants, compared to control group values. The mean serum sodium value in mild, moderate, and severe asphyxia were 135.33, 123.42, and 121.53 mmol/l respectively. Mean serum potassium values were 4.11, 4.86, and 5.51 mmol/l respectively. Mean serum creatinine 0.72, 1.00, and 1.83 mg/dl respectively. Mean blood urea levels were 36.17, 58.97, and 88.06 mg/dl respectively. A significant difference was observed between the mean values of serum electrolytes and patients’ asphyxia grade.Conclusions: The study findings can conclude that electrolyte abnormalities are common among perinatal asphyxia patients, and babies with perinatal asphyxia developed hyponatremia, and hyperkalemia at a higher frequency, and significant raises of serum creatinine, and blood urea was also observed, which was proportionate to the severity of asphyxia.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 93%

Electrolyte abnormalities in patients with perinatal asphyxia

Prodhan

Azad²,

Shormin³

et al. 2022

Int J Contemp Pediatr

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“…Mean crea nine value was raised in the second day of life of studied neonates. According to the study done15 by Roy et al serum crea nine on day 1 was 1.14±0.57 and rd on 3 day of life 1.24±0.5 which is nearly similar to the present study. The mean serum crea nine value in the6…”

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confidence: 92%

Incidence of Acute Renal Failure in Full Term Neonates with Birth Asphyxia

Jha

Tamrakar

2019

Birat J. Health Sci.

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Introduction: Birth asphyxia is an eventuality having far reaching consequences in the neonatal period. Hypoxia and ischemia can cause damage to almost every tissue and organ in the body and various target organs involved. Renal insult is a recognized complication of birth asphyxia and carries a poor prognosis. Timely detection of renal dysfunction and appropriate management may favorably alter the prognosis in many neonates with birth asphyxia. Objective: The present study was done to find out the incidence of acute renal failure in the full term neonates with birth asphyxia. Methodology: A cross sectional study was conducted at Birat Medical College Teaching Hospital, Morang, Nepal from 1st September 2017 to 28th February 2018. Fifty full term neonates born with Apgar score of <6 at 5 minutes and fulfilling inclusion criteria were enrolled in the study. Asphyxiated neonates having Serum creatinine >1.5gm/dl or urine output<1ml/kg/hr were labeled as cases of Acute Renal Failure. Blood sample for serum creatinine was collected at 24hrs, 48 hrs and 72 hrs of life. Results A total of 50 term asphyxiated neonates were enrolled in the present study. Among them 54% and 46% were males and females respectively with male to female ratio of 1.2:1. In the present study 62% of cases developed acute renal failure in either of the first three days of life with mean urine output 1.02±0.27ml/kg/hr and mean serum creatinine of 1.49±0.32 mg/dL. The incidence of oliguric renal failure was 52% and non oliguric renal failure was 48%.The association between serum creatinine and urine output was statistically significant. Conclusion: In the present study birth asphyxia has been an important cause of neonatal acute renal injury, revealing 31 (62%) cases. Monitoring urine output and serum creatinine has helped in detecting the asphyxiated neonates with acute renal injury in the early stage.

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“…5 In a study by Roy et al the mean urine volume gradually decreased as HIE grading increased and it was statistically significant (p<0.05). 13 Also Rai et al in their study stated that mean urinary output in severely asphyxiated babies was significantly lower as compared to mildly and moderately asphyxiated babies (p<0.01). 18 Similar to the present study where mean urine output in HIE Grade I neonates was 1.5±0.38 ml/kg/ hour whereas in Grade II and Grade III mean urine output was 1.3±0.53 ml/kg/hour and 1.1±0.39 ml/kg/hour respectively.…”

Section: Discussionmentioning

confidence: 90%

“…11 Also in the study by Roy et al 31.25% cases had HIE Grade I, 40.62% had Grade II, and 28.12% patients had HIE Grade III. 13 Panthee et al observed 24.4%cases developed HIE Grade I, 23.17% developed HIE Grade II and the remaining 9.75% cases developed HIE Grade III. 14 In the present study, Grade I HIE was seen in 68.0% neonates, Grade II was seen in 22.70% and 9.30% cases had Grade III HIE.…”

Section: Discussionmentioning

confidence: 96%

Acute Renal Failure in Newborns with Birth Asphyxia

Kanodia

Sah

et al. 2022

J. Nepalgunj Med. College

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Introduction: Perinatal asphyxia is one of the common causes of neonatal morbidity and mortality. It can affect almost all the body organs and most frequently affected organs are kidneys. Acute Renal Failure is the commonest renal complication, manifested by changes in urine output and blood chemistries. Aims: To evaluate the renal function in asphyxiated newborns. Methods: This cross-sectional study was conducted, from August 2021 to February 2022, on 95 term neonates admitted in Neonatal Intensive Care Unit of Nepalgunj Medical College, Kohalpur for birth asphyxia as per World Health Organization definition. All neonates with Hypoxic Ischemic Encephalopathy were staged by Sarnat and Sarnat staging. After 48 hours of life, blood sample was sent for investigations. Urine output was monitored and neonates were managed according to the hospital protocol. Results: Male to female ratio was M:F 1.90:1. Percentage of acute renal failure was higher in babies with higher Hypoxic Ischemic Encephalopathy grades. It was seen in 12% in Grade I, 82% in Grade II and 100% in Grade III. Renal failure had significant association with Hypoxic Ischemic Encephalopathy staging(p<0.05).The means of serum creatinine significantly increased with the increase in Hypoxic Ischemic Encephalopathy grades (p<0.05). Mean serum creatinine among Grade I, Grade II and Grade III newborns were 0.9±0.44, 2.2±.93and 2.9±0.38 mg/dl respectively. Mean urinary output significantly decreased as the grades of Hypoxic Ischemic Encephalopathy increased (p<0.05) with mean urine output 1.5±0.38, 1.3±0.53and 1.1±0.39 ml/kg/hour respectively in Grade I, Grade II and Grade III. Conclusion: Neonates with higher grades of Hypoxic Ischemic Encephalopathy had higher values of serum creatinine. Urine output decreased as the grading of asphyxia increased

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Study of Renal Profile in Babies with Perinatal Asphyxia in a Tertiary Care Hospital: A Prospective Case Control Study

Cited by 3 publications

References 16 publications

Electrolyte abnormalities in patients with perinatal asphyxia

Electrolyte abnormalities in patients with perinatal asphyxia

Incidence of Acute Renal Failure in Full Term Neonates with Birth Asphyxia

Acute Renal Failure in Newborns with Birth Asphyxia

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