Study of retinal structure and function in patients with major depressive disorder, bipolar disorder or schizophrenia: A review of the literature

Tan, A.; Schwitzer, Thomas; Conart, Jean‐Baptiste; Angioï-Duprez, K.

doi:10.1016/j.jfo.2020.04.004

Cited by 14 publications

(7 citation statements)

References 58 publications

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“…MDD severely affects the patients themselves and their families. Negative emotions have a negative impact on patients, and patients may lose their enthusiasm, immerse themselves in negative emotions, and fail to live a normal life [ 15 , 16 ]. With the continuous progress of science and technology, imaging is also developing rapidly.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Neural Activity among Abnormal Brain Regions in Patients with Major Depressive Disorder by Magnetic Resonance Imaging Features

Wang

Jia

Zhao

et al. 2022

Computational and Mathematical Methods in Medicine

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In order to explore the diagnostic value of magnetic resonance imaging (MRI) for neural activity among abnormal brain regions in patients with major depressive disorder (MDD), thirty patients with MDD (observation group) were selected for comparison with 30 healthy people without MDD (control group). The included subjects were examined by MRI to compare the MRI features and were analyzed for regional homogeneity (ReHo) and amplitude low-frequency fluctuations (ALFF). The results showed that compared with the control group, the brain regions with increased ReHo and ALFF in the observation group were medial frontal gyrus (right), middle temporal lobe (left), inferior parietal lobe (left), and posterior cerebellar lobe (right); the brain region with increased ReHo and ALFF in the observation group was the middle temporal gyrus (right). Compared with the control group, there were significant differences in ReHo and ALFF in the observation group. It was found that the brain function of patients with MDD was abnormal compared with that of the normal subjects, and the brain network activity was also abnormal. MRI features can be used to explore abnormal brain regions in patients with MDD and have positive guiding value.

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Section: Discussionmentioning

confidence: 99%

Diagnosis of Neural Activity among Abnormal Brain Regions in Patients with Major Depressive Disorder by Magnetic Resonance Imaging Features

Wang

Jia

Zhao

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Responding to the rapidly expanding body of research linking ocular pathology and AD brain lesions, the American Alzheimer’s Association convened a ‘think tank’ in mid-2019 aimed at establishing the foundations for population-based detection and monitoring of mild cognitive impairment and AD [ 37 ]. Other disorders for which retinal imaging is being explored as a screening/prognostic tool include Parkinson’s disease [ 20 ], psychiatric diseases including schizophrenia, bipolar disorder and major depressive disorder [ 39 ] and multiple sclerosis [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Is the eye a window to the brain in Sanfilippo syndrome?

Beard

Chidlow

Neumann

et al. 2020

acta neuropathol commun

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Sanfilippo syndrome is an untreatable form of childhood-onset dementia. Whilst several therapeutic strategies are being evaluated in human clinical trials including i.v. delivery of AAV9-based gene therapy, an urgent unmet need is the availability of non-invasive, quantitative measures of neurodegeneration. We hypothesise that as part of the central nervous system, the retina may provide a window through which to ‘visualise’ degenerative lesions in brain and amelioration of them following treatment. This is reliant on the age of onset and the rate of disease progression being equivalent in retina and brain. For the first time we have assessed in parallel, the nature, age of onset and rate of retinal and brain degeneration in a mouse model of Sanfilippo syndrome. Significant accumulation of heparan sulphate and expansion of the endo/lysosomal system was observed in both retina and brain pre-symptomatically (by 3 weeks of age). Robust and early activation of micro- and macroglia was also observed in both tissues. There was substantial thinning of retina and loss of rod and cone photoreceptors by ~ 12 weeks of age, a time at which cognitive symptoms are noted. Intravenous delivery of a clinically relevant AAV9-human sulphamidase vector to neonatal mice prevented disease lesion appearance in retina and most areas of brain when assessed 6 weeks later. Collectively, the findings highlight the previously unrecognised early and significant involvement of retina in the Sanfilippo disease process, lesions that are preventable by neonatal treatment with AAV9-sulphamidase. Critically, our data demonstrate for the first time that the advancement of retinal disease parallels that occurring in brain in Sanfilippo syndrome, thus retina may provide an easily accessible neural tissue via which brain disease development and its amelioration with treatment can be monitored.

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“…The bioelectrical function of these cells can be measured using pattern electroretinography (PERG) [10], while their structure can be measured by optical coherent tomography (OCT). In the available literature, only a few study results have described changes in PERG recordings [11][12][13][14][15] and OCT [16] in individuals with MD. That is why we decided to analyze the retinal function and thickness in a newly diagnosed, untreated group of individuals with major depression.…”

Section: Introductionmentioning

confidence: 99%

Pattern electroretinography in individuals with major depression

Lubiński¹,

Grabek-Kujawa²,

Samochowiec³

et al. 2023

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Aim of the study: Investigation of pattern electroretinography in individuals with major depression (MD). Material and methods:In 25 untreated individuals with MD (mean age 46.8 years) and in 25 of age-and sex-matched healthy controls (mean age 46.9 years) the following examinations were performed: visual acuity (Snellen), intraocular pressure, biomicroscopy of anterior and posterior segment of eye, macular structure (SD-OCT-Zeiss) and pattern electroretinogram (PERG-ISCEV standards). An analysis of correlation between the parameters of PERG and depression severity (the Hamilton Scale) was performed. To estimate the diagnostic power of the PERG test a receiver operating characteristics (ROC) curve was used. Obtained data were used to analyze the significance level p < 0.05. Results: In both groups the clinical results and macular structure were normal. In the PERG test in the MD group a signifi-

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Study of retinal structure and function in patients with major depressive disorder, bipolar disorder or schizophrenia: A review of the literature

Cited by 14 publications

References 58 publications

Diagnosis of Neural Activity among Abnormal Brain Regions in Patients with Major Depressive Disorder by Magnetic Resonance Imaging Features

Diagnosis of Neural Activity among Abnormal Brain Regions in Patients with Major Depressive Disorder by Magnetic Resonance Imaging Features

Is the eye a window to the brain in Sanfilippo syndrome?

Pattern electroretinography in individuals with major depression

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