Study of Seroconversion of Antibody to Human T‐Cell Lymphotropic Virus Type‐I in Children of Okinawa, Japan

Kajiyama, Wataru; Kashiwagi, Seizaburo; Hayashi, J; Nomura, Hideyuki; Ikematsu, Hideyuki; Noguchi, Akinori; Nakashima, Kouya; Okochi, Kazuo

doi:10.1111/j.1348-0421.1990.tb01008.x

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…In fact, recent genetic studies based on mitochondrial DNA indicated that only Pygmy-to-Bantu maternal gene flow occurred [38]. As HTLV-1 and -2 seem preferentially transmitted from men to women [4,39], such rare contacts are likely not to spread HTLVs outside the Pygmy community.…”

Section: Why Is the Level Of Htlv-1 And Htlv-2 Infection Much Higher mentioning

confidence: 99%

HTLV-2B Strains, Similar to Those Found in Several Amerindian Tribes, Are Endemic in Central African Bakola Pygmies

Mauclère¹,

Afonso²,

Meertens³

et al. 2011

The Journal of Infectious Diseases

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Section: Why Is the Level Of Htlv-1 And Htlv-2 Infection Much Higher mentioning

confidence: 99%

HTLV-2B Strains, Similar to Those Found in Several Amerindian Tribes, Are Endemic in Central African Bakola Pygmies

Mauclère¹,

Afonso²,

Meertens³

et al. 2011

The Journal of Infectious Diseases

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“…Several investigators have described the presence of seronegative HTLV-I carriers (Saito et al, 1989;Kajiyama et al, 1990). Some HTLV-I carriers have been reported to be negative for serum anti-HTLV-I antibodies against viral structural proteins on screening examinations (Ehrlich et al, 1989).…”

mentioning

confidence: 99%

Absence of HTLV‐I infection among seronegative subjects in an endemic area of Japan

Kinoshita¹,

Imamura²,

Nagai³

et al. 1993

Intl Journal of Cancer

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To examine the prevalence of infection by human T-cell leukemia virus type I (HTLV-I) among seronegative subjects, healthy subjects on Tsushima Island, Japan, where the infection is endemic, were evaluated. A total of 209 healthy adults were examined for HTLV-I provirus in peripheral blood mononuclear cells by the polymerase chain reaction (PCR), as well as for anti-HTLV-I antibodies by the particle agglutination (PA) method, the enzyme-linked immunosorbent assay (ELISA) and by immunofluorescence analysis (IF). A total of 76 subjects were positive and 133 were negative for the provirus, showing a close correlation with the results of 3 assays for anti-HTLV-I serum antibodies. None of the seronegative subjects reacted positively on PCR analysis. These observations indicate that seronegative HTLV-I carriers are rare in an area of Japan in which this viral infection is endemic.

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HTLV-I Maternal Transmission in Martinique, Using Serology and Polymerase Chain Reaction

Monplaisir

Neisson-Vernant²,

Bouillot³

et al. 1993

AIDS Research and Human Retroviruses

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We have investigated HTLV-I and HTLV-II infection in children born to HTLV-I-seropositive or indeterminate Western blot mothers in Martinique by using the polymerase chain reaction (PCR). Only HTLV-I and no HTLV-II-positive samples were found in this study. All the samples from HTLV-I-seropositive children and adults were PCR positive, whereas the four HIV-I-seropositive and Western blot HTLV-I-negative mothers and their eight children were all PCR negative. Therefore, PCR and serology were in complete agreement in these patients. However, two of the six mothers who were first indeterminate by Western blot, and who later became seronegative, were found positive by PCR. Of the 27 children (ages 2-12 years), born to HTLV-I-seropositive and PCR-positive mothers, 2 were seropositive and PCR positive, 5 were seronegative and PCR positive with 2 primer pairs in gag and pol, and 4 were seronegative and PCR positive with only 1 of the primer pairs. In contrast to an initial rate of transmission of 7% estimated by serology we found a rate of transmission of 28 to 41% (whether or not children who were positive with only one of the primer pairs were included). Thus, our study confirms that PCR is useful in detecting HTLV-I infection in children before seroconversion and underlines the potential lack of sensitivity of serology to detect contaminating HTLV-I blood units in endemic areas.

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Study of Seroconversion of Antibody to Human T‐Cell Lymphotropic Virus Type‐I in Children of Okinawa, Japan

Cited by 7 publications

References 16 publications

HTLV-2B Strains, Similar to Those Found in Several Amerindian Tribes, Are Endemic in Central African Bakola Pygmies

HTLV-2B Strains, Similar to Those Found in Several Amerindian Tribes, Are Endemic in Central African Bakola Pygmies

Absence of HTLV‐I infection among seronegative subjects in an endemic area of Japan

HTLV-I Maternal Transmission in Martinique, Using Serology and Polymerase Chain Reaction

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