Study of Serum Biomarkers in Females Hemodialysis Patients

Abstract

The renal bone disease is one of the metabolic disorder in renal failure patients that causes morbidity. The aim was to study the biomarkers and the incidence of renal osteodystrophy (bone turnover diseases) in hemodialysis patients. Method: 50 females’ patients from Al Basra-Teaching hospital/ Iraq who maintenance on hemodialysis (at least 1 year) and healthy females (n=30) as comparing group were included. Serum vitamin D, parathyroid hormone, osteocalcin and some bone parameters were tested. Results: a significant decreasing in serum vitamin D in females patients under dialysis (12.770 ng/ml) comparing to control group (20.8167 ng/ml). Osteocalcin level was increased in patients (54.3114 ng/ml) compared to healthy group. In general the PTH level was elevated significantly in dialysis patients (262.211pg/ml), also elevation in ALP level (221.084IU/L) was found. The patients according to PTH level showed a renal bone disease. About 30 females’ patients (60%) revealed a high bone turnover followed by 20 patients (40%) with low bone turnover disease. Conclusion: deficiency in vitamin D with incidence of renal osteodystrophy in females’ hemodialysis patients.