Study of Severity of Hyponatraemia and Its Clinical Outcome in Patients Admitted to Tertiary Care Icu

Rangaswamaiah, Hareesh; Siddaraju, Jayakumar; Shivaraju, Rajdeepak Valagerahalli; Redrouthu, Ashok Kumar; Rahaman, Mohammed Zia Ur

doi:10.14260/jemds/2016/725

Cited by 1 publication

(8 citation statements)

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“…The incidence of severe hyponatremia reported in different studies was 2-3%, 28%, 16.4% and 9%. 4,6,23,28,25 In the present study, the incidence of euvolemic, hypovolemic and hypervolemic hyponatremia was 51%, 21% and 28% respectively which was one with few earlier studies. 21,28,29 The commonest CNS symptoms were disorientation (20%), drowsiness (22%), seizure (2%) and coma (0%).…”

Section: Discussionsupporting

confidence: 59%

“…The incidence of hyponatremia ranges from 1.40%, 22%, and 28.25% in different studies. 4,5,23 Prevalence of severe, moderate and mild hyponatremia in this study was 10%, 17% and 73% respectively. The incidence of severe hyponatremia reported in different studies was 2-3%, 28%, 16.4% and 9%.…”

Section: Discussionmentioning

confidence: 47%

“…Nausea was observed in 30% patients by Agrawal SM et al, while it was 12% in another study. 23,24 Fever was reported in 15.5% in a study. 23 The causes of hyponatremia were SIADH (34%), sepsis (13%), chronic liver disease (3%), pancreatitis (2%), endocrine (11%), CVS (6%), renal (15%), diuretic (11%), GI loss (5%) and CNS (2%).…”

Section: Discussionmentioning

confidence: 93%

“…Confusion followed by altered sensorium were major symptoms in severe hyponatremia while in another study altered sensorium followed by seizure were the major symptoms. 23,24 Maqbool M et al, observed confusion in 48%, lethargy in 20% and seizure in 10%. 21 Agrawal SM et al, observed confusion in 41.4%, altered sensorium in 17.1% and seizure in 29%.…”

Section: Discussionmentioning

confidence: 98%

“…Similar male dominance was reported in earlier studies. [23][24][25] Whereas, few literatures show higher incidence of hyponatremia in females than males. 26,27 The incidence of hyponatremia was 10.7% in this study.…”

Section: Discussionmentioning

confidence: 99%

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Aetiological evaluation of hyponatremia in hospitalised patients and its prognostic implication in disease outcome

et al. 2019

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Background: Hyponatremia is very common in clinical practice. Proper evaluation of hyponatremia is essential as causes are many and management of it depends on the aetiology and its long-term outcome. Aetiological evaluation of hyponatremia in hospitalised patients and its prognostic implication in disease outcome was undertaken as such studies were rare in this zone.Methods: One hundred patients whose serum sodium level was <135 mEq/L were studied. The serum sodium and osmolality and urinary sodium and osmolality were estimated in all. The degree of hyponatremia, outcome after treatment and duration of hospital stay were analysed.Results: The mean age was 60.5 years. There were 73% males and 27% females. The incidence of hyponatremia was 10.7%. The mean serum sodium was 129.96 mEq/L and urinary sodium was 40.3 mEq/lL while the mean serum osmolality was 272.8 mOsm/kg and urinary osmolality was 357.7 mOsm/kg. Euvolemia, hypervolemia and hypovolemia were observed in 51%, 28% and 21% respectively. The common clinical features were drowsiness (22%), disorientation (20%), fever (28%), nausea (24%), anorexia (15%), vomiting (14%), hiccup (10%). The common causes were SIADH (34%), renal causes (15%), sepsis (13%), endocrinopathy (11%) and diuretics (11%). The common comorbidities were hypertension (66%) and diabetes mellitus (41%). The mortality was 7%. No side effect was observed during management of hyponatremia.Conclusions: Proper management of hyponatremia irrespective of aetiology had a better prognosis. Factors which are modifiable should be searched and rectified.

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