Study of Silica Nanoparticle Composite on Silica-Hydrogen Peroxide Complexations and Their Effects in Catechol Based Adhesives

Pinnaratip, Rattapol

doi:10.37099/mtu.dc.etdr/1044

Cited by 1 publication

(1 citation statement)

References 102 publications

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“…An L 9 orthogonal array was used to determine the contribution of four factors and their relative contributions to the performance of the composite adhesive (Table 1) [28][29][30]. These factors were: (A) the PEG architecture, (B) the PEG precursor concentration, (C) the PBS concentration, and (D) the SiP concentration.…”

Section: Robust Design Experimentsmentioning

confidence: 99%

Utilizing Robust Design to Optimize Composite Bioadhesive for Promoting Dermal Wound Repair

et al. 2023

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Catechol-modified bioadhesives generate hydrogen peroxide (H2O2) during the process of curing. A robust design experiment was utilized to tune the H2O2 release profile and adhesive performance of a catechol-modified polyethylene glycol (PEG) containing silica particles (SiP). An L9 orthogonal array was used to determine the relative contributions of four factors (the PEG architecture, PEG concentration, phosphate-buffered saline (PBS) concentration, and SiP concentration) at three factor levels to the performance of the composite adhesive. The PEG architecture and SiP wt% contributed the most to the variation in the results associated with the H2O2 release profile, as both factors affected the crosslinking of the adhesive matrix and SiP actively degraded the H2O2. The predicted values from this robust design experiment were used to select the adhesive formulations that released 40–80 µM of H2O2 and evaluate their ability to promote wound healing in a full-thickness murine dermal wound model. The treatment with the composite adhesive drastically increased the rate of the wound healing when compared to the untreated controls, while minimizing the epidermal hyperplasia. The release of H2O2 from the catechol and soluble silica from the SiP contributed to the recruitment of keratinocytes to the wound site and effectively promoted the wound healing.

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Section: Robust Design Experimentsmentioning

confidence: 99%