Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers

Primary Pulmonary Hypertension with Severe Systemic Hypertension, Raynaud's Phenomenon and Relative Polycythemia.

“…Further investigation revealed that the levels of coagulation markers such as TATand fibrinopeptide A were increased, indicating that an increase of coagulation was present. Interestingly, the PAI-1 level was significantly increased, suggesting that activity of fibrinolysis would be decreased.The hemostatic states such as an increase of coagulation and decrease of fibrinolysis are similar to those of chronic disseminated intravascular coagulation (DIC) (9,10). The hyperviscosity state in the patient could affect those hemostatic states.…”

Effect of Combined Therapy of Danaparoid Sodium and Tranexamic Acid on Chronic Disseminated Intravascular Coagulation Associated With Abdominal Aortic Aneurysm

“…In a previous study, we reported that the degree to which the fibrinolytic system is activated varies according to the underlying disease responsible for DIC and we have named the condition involving a markedly enhanced fibrinolytic system as "fibrinolysis dominant DIC". 3 The fibrinolysis dominant DIC is characterized by the activation of both coagulation and fibrinolysis and according to our proposition, DIC associated with aortic aneurysm is fibrinolysis dominant DIC. The representative disease of fibrinolysis dominant DIC is acute promyelocytic leukemia (APL).…”

“…Furthermore, compared witht he normal range, FDP and D-dimer concentrations were elevated (Table 1). Based on his markedly increased plasma concentrations of thrombin -antithrombin complex (TAT) and plasminplasmin inhibitor complex (PIC), he was diagnosed as having fibrinolysis dominant DIC, 3 which is characterized by the activation of both coagulation and fibrinolysis. The usual level of PIC is above 4 g/ml.…”

No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats

“…which clinically resembles DIC due to sepsis. The other is a TF-induced model of DIC, which clinically resembles DIC in the setting of acute leukemia (5,21,22). The following features were common to both models examined in this study: Markedly increased plasma TAT levels were observed, as were significantly depressed plasma fibrinogen levels and platelet counts.…”