Study of the Biocompatibility of Titanium-Niobium Implants by the Parameters of Their Osseointegration under Experimental Conditions

Olesova, V. N.; Шашмурина, В Р; Shugailov, I. A.; Olesov, Egor E.; Mirgazizov, M. Z.

doi:10.1007/s10517-019-04418-y

Cited by 5 publications

(3 citation statements)

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“…These results are consistent with findings reported earlier with respect to the compatibility of S_TiCp [ 9 , 25 , 30 , 31 , 32 ]. Recent studies have highlighted the biocompatibility of titanium-niobium alloys on various cell lines such as fibroblasts, osteoblasts, mesenchymal stem cells [ 33 , 34 , 35 , 36 ]. Other investigations have reported that the use of a Ti–26Nb (at.%) alloy not only reduces the Young module, but reveals high biocompatibility on osteoblast cells, comparable to control or cells growing onto TiCp [ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

et al. 2022

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Titanium dental implants have common clinical applications due to their biocompatibility, biophysical and biochemical characteristics. Although current titanium is thought to be safe and beneficial for patients, there are several indications that it may release toxic metal ions or metal nanoparticles from its alloys into the surrounding environment, which could lead to clinically relevant complications including toxic reactions as well as immune dysfunctions. Hence, an adequate selection and testing of medical biomaterial with outstanding properties are warranted. This study was designed to explore the biocompatibility of smooth titanium-niobium alloy (S_TiNb) versus smooth titanium commercially pure (S_TiCp)—a reference in implantology. All experiments were performed in vitro using human osteoblast-like SaOs-2 and monocyte THP-1 cell lines as models. Cell adhesion and growth morphology were determined by scanning electron microscopy, while cell viability was evaluated using WST-1 assay. Because niobate anions or niobium nanoparticles can be released from implants during biomaterial-cell interaction, potential immunotoxicity of potassium niobate (KNbO3) salt was evaluated by examining both metabolic activity and transcriptomic profiling of treated THP-1 monocytes. The main findings of this study are that S_TiCp and S_TiNb discs do not show an impact on the proliferation and viability of SaOs-2 cells compared to polystyrene surfaces, whereas a significant decrease in THP-1 cells’ viability and metabolic activity was observed in the presence of S_TiNb discs compared to the control group. However, no significant changes were found neeither at the metabolic activity nor at the transcriptomic level of THP-1 monocytes exposed to KNbO3 salt, suggesting that niobium has no effect on the immune system. Overall, these data imply a possible toxicity of S_TiNb discs toward THP-1 cells, which may not be directly related to niobium but perhaps to the manufacturing process of titanium- niobium alloy. Thus, this limitation must be overcome to make titanium alloy an excellent material for medical applications.

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Section: Discussionmentioning

confidence: 99%

In Vitro Molecular Study of Titanium-Niobium Alloy Biocompatibility

et al. 2022

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“…The Nb47Ti alloy used in this work presents a metastable b phase of body-centered cubic (BCC) structure (Ref 37 -43). It is widely used in the fabrication of superconducting materials, and due to its biocompatibility and low modulus of elasticity, it could be used in medical applications (Ref [43][44][45][46][47][48]. In this paper, samples manufactured by L-PBF using plasma atomized (PA) and hydride-dehydride (HDH) powders were compared.…”

Section: Introductionmentioning

confidence: 99%

Comparing Spherical and Irregularly Shaped Powders in Laser Powder Bed Fusion of Nb47Ti Alloy

Guzmán

Nobre

Júnior

et al. 2021

J. of Materi Eng and Perform

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Literature reports that irregularly shaped powder has lower flowability and apparent density than spherical shaped powder, factors that hinder its use in additive manufacturing, although its cost is potentially lower. In this study, four samples of Nb47Ti alloy manufactured by laser powder bed fusion from plasma atomized (PA) and hydride-dehydride (HDH) powders with different scanning strategies and interstitial element content were compared. Laser power levels of 200 W and 300 W were investigated. To keep a constant powder mass under the laser beam, the processing table displacement for samples from the HDH powder was twice larger than the 30 lm used for samples from the PA powder procedure, due to the lower apparent density of the HDH powder. It was possible to achieve porosity levels below 1% with both powders. However, the power of 200 W generated 13% of porosity in the HDH samples. A similar microstructure formed by melt pools and cellular dendritic structure in a b phase matrix of body-centered cubic (BCC) structure was obtained in all samples. Furthermore, the low interstitial element content of samples from PA powder resulted in lower microhardness when compared to the higher interstitial element content of samples from HDH powder. Keywords hydride-dehydride (HDH) powder, laser powder bed fusion (l-PBF), microstructure, Nb47Ti (Ti-53%Nb), plasma atomized (PA) powder, porosity This invited article is part of a special topical focus in the Journal of Materials Engineering and Performance on Additive Manufacturing.

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“…Its physical properties are very similar to those of Ti-6Al-4V (titanium-6-aluminum-4-vanadium). Increased corrosion resistance has been observed; moreover, the ions in niobium (Nb) have been reported to be less toxic than those of V. [6][7][8][9][10][11] In this experimental animal study, we aimed to investigate the bone-implant connections (BICs) of Ti-Al 6 V 4 and Ti-Al 6 Nb 7 implants histologically. Two types of surface morphology, RBM and SLA, were used for the implants.…”

Section: Introductionmentioning

confidence: 99%