2006
DOI: 10.1016/j.ijpharm.2005.12.012
|View full text |Cite
|
Sign up to set email alerts
|

Study of the critical points of HPMC hydrophilic matrices for controlled drug delivery

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
35
0
1

Year Published

2007
2007
2016
2016

Publication Types

Select...
6
3

Relationship

1
8

Authors

Journals

citations
Cited by 65 publications
(37 citation statements)
references
References 28 publications
1
35
0
1
Order By: Relevance
“…Diffusion is the predominant drug release mechanism from high molecular weight HPMC and PEO matrices which swell to a higher extent. Swelling phenomenon increases matrix size; therefore, diffusional path length is increased (28). Drug entity present in the matrix core may ultimately be requiring more time to travel towards the matrix surface.…”
Section: Drug Release Studymentioning
confidence: 99%
“…Diffusion is the predominant drug release mechanism from high molecular weight HPMC and PEO matrices which swell to a higher extent. Swelling phenomenon increases matrix size; therefore, diffusional path length is increased (28). Drug entity present in the matrix core may ultimately be requiring more time to travel towards the matrix surface.…”
Section: Drug Release Studymentioning
confidence: 99%
“…Although many materials can be used to modulate drug release from these systems, hydrophilic polymers are the most employed, especially the cellulose derivative hypromellose (1)(2)(3)(4).…”
Section: Introductionmentioning
confidence: 99%
“…Water soluble drugs are released from the polymer matrix primarily by diŠusion, while poorly watersoluble drugs are released predominantly by erosion mechanism. 28,29) The equations for the mathematical models employed in our study along with the results are shown in Table 5. The results suggest that PVP, being a hydrophilic polymer, has a major in‰uence on drug release, permeation and physical characteristics of theˆlms, as evidenced by an increase in the amount of drug release and permeation, with increase in the proportion of PVP in formulations MF-1 to MF-4.…”
Section: Resultsmentioning
confidence: 99%