Study of the effect of vitamin D supplementation on glycemic control in type 2 diabetic prevalent hemodialysis patients

Abstract

Vitamin D is claimed to have an adjuvant effect on glycemic control by dual action on pancreatic β-cells and insulin resistance. The aim of this study was to assess the possible effect of short-term alfacalcidol supply on glycemic control in type 2 diabetic hemodialysis (HD) patients. Twenty type 2 diabetic HD patients (using diet and oral drugs but not insulin) were randomly selected from our dialysis unit as well as 20 non-diabetic HD patients as control. A third group of 12 healthy subjects were studied as well. All three groups were similar in age, sex, and body mass index. Oral alfacalcidol therapy was administrated daily as recommended by Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines for 12 weeks guided by monthly serum phosphorus and Cax PO4 product. Corrected total calcium, phosphorus, intact parathyroid hormone, 25-hydroxy vitamin D (25[OH]D), and glucoparameters (fasting blood glucose, glycated hemoglobin [HbA1c%], insulin resistance by homeostatic model assessment, and β-cell function by HOMA-β%) were measured under basal conditions and after 3 months of therapy. 25(OH)D was non-significantly lower in diabetic than non-diabetic HD patients, but significantly lower than healthy subjects at the start of the study. However, vitamin D level increased significantly after 3 months of trial, although the levels did not reach normal values. This vitamin D rise was associated with highly significant improvement in concentrations of fasting blood sugar (FBS), fasting insulin, HbA1c%, and HOMA-β-cell function in diabetic and non-diabetic controls. However, there was a significant rise in insulin resistance after treatment. The percentage of change was evident more in diabetics regarding FBS and 25(OH)D concentration. Adjustment of 25(OH)D level in type 2 diabetic prevalent HD patients may improve, at least with short-term therapy, glycemic control mainly through improving β-cell function.

Effects of Topical 1,25 and 24,25 Vitamin D on Diabetic, Vitamin D Deficient and Vitamin D Receptor Knockout Mouse Corneal Wound Healing

“…It is estimated that 1 billion people worldwide are vitamin D (Vit D) insufficient or deficient [8]. Vit D insufficiency has been linked to numerous pathological conditions including immune/autoimmune disorders and diabetes [9][10][11][12]. Vit D supplementation may diminish the prevalence and adverse outcomes of these diseases and may reduce all-cause mortality [13][14][15].…”

Anti-proteinuria effect of active vitamin D in patients with type 2 diabetic nephropathy

“…Contrary to the results of the present study, Ibrahim et al . (2015)[ 28 ] showed that the taking vitamin D supplements for 6 months led to a significant increase in calcium level. One of the reasons for the difference between the results of this study and our results could be due to the differences in the statistical population.…”

Is There a Relation Between Serum Vitamin D Level and Microvascular Comlications in Type 2 Diabetes?

“…[22] Furthermore, recent studies suggest that vitamin D supplementation has beneficial effects on glucose homeostasis and glycemic control. [23,24] However, there are limited data on what the optimum vitamin D level might be, and still no consensus on the dose of vitamin D that should be administered to achieve a 25(OH) D concentration of 20 or 30 ng/mL. Different cutoff values for vitamin D have been suggested in literature.…”