Study of the Effect of Nortriptyline and Fluvoxamine on Psychomotor Functions in Healthy Volunteers

Khade, Ajay; Bashir, Mohammed Shakeel Mohamemed; Kale, AS; Turankar, Avinash Vikram

doi:10.4103/0253-7176.78506

Cited by 6 publications

(10 citation statements)

References 11 publications

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“…In our study, nortriptyline was significantly associated with headache, dizziness, constipation, drowsiness, weakness, and aggression, which seems to be in line with other studies 10–13,23,24. Khade et al reported that drowsiness, tiredness, and dullness were related to this drug, and Uher et al further reported that dry mouth, constipation, and weight gain were associated with nortriptyline 10,12…”

Section: Discussionsupporting

confidence: 92%

“…In our study fluoxetine was associated with nausea, similar to other studies 10–13,23,24. Meanwhile, Khade et al and Otsubo et al reported that fluvoxamine was associated with nausea and Uher et al reported that escitalopram was associated with insomnia, diarrhea, and yawning 10,12,24. In our study, fluoxetine was significantly associated with nausea, whereas Bhurghri et al reported that nortriptyline was significantly associated with nausea and headache 18.…”

Section: Discussionsupporting

confidence: 88%

“…While some studies have shown that nortriptyline is more effective than fluoxetine, 13 – 16 others have shown fluoxetine to be more effective than nortriptyline. 12 , 17 , 18 On the other hand, some studies have shown that there was no significant difference between the two drugs, 19 – 21 although some researchers believe that there is a significant difference between the two drugs depending on age and gender. 22 SSRIs are believed to be better tolerated and to have a better safety profile than the tricyclic antidepressants.…”

Section: Introductionmentioning

confidence: 99%

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Nortriptyline versus fluoxetine in the treatment of major depressive disorder: a six-month, double-blind clinical trial

Hashemi

Hg²,

Mohammadi³

et al. 2012

CPAA

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BackgroundDepression is a common psychiatric disorder worldwide, including in Iran, and is estimated to affect 10%–15% of the population. Antidepressant drugs can have multiple side effects, so a good choice of drug is important for successful treatment. This study compared the efficacy of nortriptyline with that of fluoxetine in the treatment of patients with major depressive disorder and assessed related factors, including age, gender, and level of education.MethodsThe study was a double-blind, randomized clinical trial with a six-month follow-up period. Participants were 120 patients aged 15–60 years with a diagnosis of major depressive disorder based on a psychiatry interview and the Beck depression rating scale, which were performed at the beginning, middle, and end of the study. The patients were treated with nortriptyline or fluoxetine. The paired t-test, independent t-test, and the k chi-square test were used to analyze the data.ResultsTwenty-three patients dropped out and 97 remained in the trial. Before intervention, the mean depression score was 32.85 ± 6.23 in the nortriptyline group and 33.12 ± 6.50 in the fluoxetine group. The results of the independent t-test showed a significant difference between depression score means before and after treatment in both groups. Changes at the end of the trial compared with baseline scores were 13.4 ± 4.68 and 16.96 ± 4.96 for nortriptyline and fluoxetine, respectively. Paired t-testing showed a significant difference in the mean depression score for both the nortriptyline and fluoxetine groups. Age, gender, and level of education had no significant effects on the outcome of treatment in the two groups.ConclusionThe present study suggests that both nortriptyline and fluoxetine were effective in the treatment of depression, but that fluoxetine was more effective than nortriptyline after 3 and 6 months of treatment.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nortriptyline versus fluoxetine in the treatment of major depressive disorder: a six-month, double-blind clinical trial

Hashemi

Hg²,

Mohammadi³

et al. 2012

CPAA

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“…Journal of Psychiatry and Brain Science 14 of 33 (e.g., immunomodulators, anticonvulsants, and ATD (such as bupropion and nortriptyline)) are being excluded given the potential impact of DA, a neurotransmitter important to motor functioning [67][68][69]. Subjects periodically taking medications that impact dopamine or other compounds that may impact motor functioning (e.g., antibiotics, antihistaminic, or antiemetic) will undergo a withholding period of four weeks prior to assessments.…”

Section: Medicationmentioning

confidence: 99%

An Examination of Psychomotor Disturbance in Current and Remitted MDD: An RDoC Study

Shankman

Mittal

Walther

2020

J Psychiatry Brain Sci

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Major depressive disorder (MDD) is a serious public health problem that has, at best, modest treatment response-potentially due to its heterogeneous clinical presentation. One way to parse the heterogeneity is to investigate the role of particular features of MDD, an endeavor that can also help identify novel and focal targets for treatment and prevention efforts. Our R01 focuses on the feature of psychomotor disturbance (e.g., psychomotor agitation (PmA) and retardation (PmR)), a particularly pernicious feature of MDD, that has not been examined extensively in MDD. Aim 1 is comparing three groups of individuals-those with current MDD (n = 100), remitted MDD (n = 100), and controls (n = 50)-on multiple measures of PmR and PmA (assessed both in the lab and in the subjects' natural environment). Aim 2 is examining the structural (diffusion MRI) and functional (resting state fMRI) connectivity of motor circuitry of the three groups as well as the relation between motor circuitry and the proposed indicators of PmR and PmA. Aim 3 is following up with subjects three times over 18 months to evaluate whether motor symptoms change in tandem with overall depressive symptoms and functioning over time and/or whether baseline PmR/PmA predicts course of depression and functioning. Aim 3 is particularly clinically significant. Finding that motor functioning and overall depression severity co-vary over time, or that motor variables predict subsequent change in overall depression severity, would support the potential clinical utility of these novel, reliable, and easily administered motor assessments.

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“…3) Hand steadiness [11,12] The hand steadiness was tested on a steadiness tester. It is a device with a series of holes of varying sizes, a stylus and a digital counter.…”

Section: ) Reaction Timementioning

confidence: 99%

Effect of Power Posing on Psychomotor Performance in Healthy Volunteers- A Short Term Pilot Study

Turankar¹,

Thakre²,

Ajmera³

et al. 2019

jebmh

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BACKGROUND The emotional status of an individual can change the body language. However, off late researchers have evidenced that body poses can influence hormones like testosterone and cortisol on immediate basis. The positive power poses are more open, wider and of confident kind, whereas negative power poses are contractive and less confident kind of body postures. We hypothesized that positive power poses might increase testosterone and decrease cortisol and stress on immediate basis, thereby affecting psychomotor function. Hence, it was worthwhile to conduct this study to assess the effect of power poses on psychomotor function. METHODS 25 healthy participants were divided into 5 groups, each of 5. Group 1 performed positive power posing on 1st day and negative power posing on the next day i.e. the same group acted as positive and negative control on two different days. We did the procedure for the remaining four groups. During each session the participants were given information about the project and were first taught about the use of reaction time app and other instruments. After this we took the 1st set of readings followed by power posing. After power posing we took the 2nd set of readings. Each power pose was of 30 seconds and the total duration of procedure lasted for 4 minutes in each session. This was one time event only on the scheduled date. RESULTS The intra group analysis shows that positive power posing increases critical flicker fusion time by the magnitude of 0.73 (p= 0.0038), and has shown a drop in the reaction time by 34.22 seconds (p= 0.0926). The second intra group analysis on negative power posing demonstrated that there is a statistically and clinically relevant drop in the critical flicker fusion time by 1.7 (p= 0.0001) and there is a decrease in the hand steadiness performance which is shown by increased mistake by the performers by a magnitude of 14.57 (p= 0.1122). The reaction time has increased by a big margin of 50.75 seconds (p= 0.0004). The inter group analysis shows that the positive power posing performance statistically and significantly improved critical flicker fusion test compared to the negative posing. The positive power posing postures have a tendency to improve the performance in hand steadiness test, although the difference is non-significant, when compared to negative poses. The negative power posing adversely affects the reaction time and causes more slowness in reaction which may be very crucial and important in fine motor performance. CONCLUSIONS This study suggests that single act of positive power posing affects the various psychomotor performance tests like critical fusion test, hand steadiness test and reaction time, favorably and the negative power posing causes deterioration in above psychomotor performance parameters except hand steadiness performance.

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Study of the Effect of Nortriptyline and Fluvoxamine on Psychomotor Functions in Healthy Volunteers

Cited by 6 publications

References 11 publications

Nortriptyline versus fluoxetine in the treatment of major depressive disorder: a six-month, double-blind clinical trial

Nortriptyline versus fluoxetine in the treatment of major depressive disorder: a six-month, double-blind clinical trial

An Examination of Psychomotor Disturbance in Current and Remitted MDD: An RDoC Study

Effect of Power Posing on Psychomotor Performance in Healthy Volunteers- A Short Term Pilot Study

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