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Background:Today, many antidepressants are available, but they often cause adverse effects, particularly psychomotor and cognitive. It leads to patient maladjustment and may impair psychomotor performance. Fluvoxamine is a newer antidepressant and hence the present study was planned to investigate its effect on psychomotor functions and compare with nortriptyline and record their adverse reactions.Materials and Methods:A total of 26 healthy volunteers were included in this double-blind, placebocontrolled, crossover study. Single oral doses of fluvoxamine 50 mg, nortriptyline 50 mg and placebo were administered following a Latin square design. The objective parameters-six digit cancellation test, digit symbol substitution test, critical flicker fusion test, arithmetic ability test, hand steadiness test and subjective parameters such as visual analogue scale 1, 2, 3 were tested at 0, 2 and 4 h. The side-effects were also investigated.Results:Nortriptyline impaired all subjective and objective psychomotor functions while fluvoxamine did not show any significant effect on objective tests. However, on subjective parameters, there was a significant effect. The side-effects observed were dryness of mouthwith the nortriptyline and nausea and headache with fluvoxamine.Conclusion:Fluvoxamine is a better antidepressant drug in comparison with nortriptyline as it causes a less impairment of psychomotor functions.

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BACKGROUND It is a known fact that giving the blood helps the other in more than one way. One pint of blood given by the donor can save the lives of as many as three individuals. The aim of the study was to estimate the effect of lipid profile after 7 th , 30 th and 90 th days of blood donation. MATERIALS AND METHODS This is a descriptive study. 30 healthy volunteers were included in the study without any major illness. Total cholesterol was estimated by CHOD-POD method. HDLc was estimated by phosphotungstic acid method. TG was estimated by GPO-POD method. LDLc was estimated by using formula of Friedewald et al. RESULTS All the parameters of lipid profile, e.g. TC, LDL, VLDL except HDL was highly significantly decreased (p < 0.001) after 7 th and the effects continued till 30 th day after blood donation, which was highly significantly decreased (p < 0.05, HDL). It was significantly increased (p < 0.05) after 7 th and 30 th day of blood donation. At 90 th day, all values were normalised. CONCLUSION The act of blood donation has favourable hypolipidaemic effect even in normal healthy volunteers, which starts as early as 7 days and gets normalised by 90 days with continued raised levels of HDL.