Study of the Efficacy of Korean Red Ginseng in the Treatment of Androgenic Alopecia

김재환,; 이상민,; 최재은,; 손상욱,

doi:10.5142/jgr.2009.33.3.223

Cited by 25 publications

(3 citation statements)

References 8 publications

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“…Many researchers believe that KRG has potential as a therapeutic modality for treatment of many dermatologic diseases. Our previous study showed that KRG may be helpful in treatment of androgenic alopecia [21]. However, there are no studies about the correlation between AA and KRG.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Korean Red Ginseng in the Treatment of Alopecia Areata

Son²

2012

Journal of Ginseng Research

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Alopecia areata (AA) is an autoimmune disease that can affect any hair-bearing area. AA is known to be caused by immunological disorder but still, the pathogenesis is not fully understood. Many therapeutic modalities have been used to treat alopecia areata, with variable efficacy and safety profiles. Unfortunately, none of these agents is definitely curative or preventive alone. We studied hair growth efficacy and safety of Korean red ginseng (KRG) in AA comparing corticosteroid intra-lesional injection (ILI) alone patient group with ILI with KRG taking patient group using Folliscope 2.5 for 12 wk. Herein, we would like to report the efficacy of KRG in the treatment of AA and recommend KRG as a useful complimentary food for gaining efficacy of treatment for AA.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Korean Red Ginseng in the Treatment of Alopecia Areata

Son²

2012

Journal of Ginseng Research

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“…Our previous study showed that KRG may be helpful in treatment of androgenic alopecia [25]. However, there are certain limitations of correlation between AD and KRG.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Korean Red Ginseng in the Treatment of Atopic Dermatitis

Lee

Son²

2011

Journal of Ginseng Research

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In order to determine the efficacy of functional foods, objective measurement of the severity of atopic dermatitis (AD) after taking foods is important. The aim of this study was to conduct an objective evaluation of whether Korean red ginseng (KRG) might be helpful for improvement of skin condition and serum IgE in patients with AD. Thirty atopic patients (18 females and 12 males) participated in this study. Patients took KRG for 16 weeks. Bioengineering methods, including the corneometer and evaporimeter, were used at the start of the study and after 8 weeks and 16 weeks. In addition, we assessed serum IgE levels and the severity scoring of the atopic dermatitis (SCORAD) index. Transepidermal water loss and skin hydration showed significant improvement after 16 weeks. A significant decrease in the SCORAD index, as well as in serum IgE level, was observed after 16 weeks. Our results demonstrated that KRG may be helpful as a functional food for patients with AD.

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“…In addition, ginseng rhizome and ginsenoside-Ro have been shown to exhibit inhibitory activity against 5α-reductase and enhance hair regrowth in a mouse model of androgenic alopecia ( Murata et al, 2012 ). Although clinical trials have found that consumption of Korean RGE improves hair density and thickness in patients with alopecia ( Kim et al, 2009 ; Oh and Son, 2012 ), the molecular mechanisms of red ginseng on anagen induction have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Hair Growth-Promoting Mechanisms of Red Ginseng Extract through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health

Truong

Jeong

2021

Prev. Nutr. Food Sci.

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This study aimed to investigate the underlying mechanisms of red ginseng extract (RGE) on regulating hair growth and hair follicle development. Results from in vitro studies showed that RGE treatment simultaneously enhanced viability and inhibited apoptosis in human hair dermal papilla cells. Moreover, RGE administration promoted telogen-toanagen transition, prolonged anagen in hair follicular cycling, and increased the size of hair follicles and skin thickness in a C57BL/6 mouse model. Furthermore, RGE treatment significantly upregulated the expression of β-catenin, phospho-glycogen synthase kinase 3β, cyclin D1, cyclin E, and Bcl-2, phospho-extracellular signal-regulated protein kinase, and phospho-Akt, which are associated with promoting hair growth. In addition, RGE enhanced skin health by activation of antioxidant defense systems. Our data demonstrates that hair regenerative mechanisms of RGE may be mediated by stimulating dermal papilla cell proliferation and enhancing skin functions.

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Study of the Efficacy of Korean Red Ginseng in the Treatment of Androgenic Alopecia

Cited by 25 publications

References 8 publications

Efficacy of Korean Red Ginseng in the Treatment of Alopecia Areata

Efficacy of Korean Red Ginseng in the Treatment of Alopecia Areata

Efficacy of Korean Red Ginseng in the Treatment of Atopic Dermatitis

Hair Growth-Promoting Mechanisms of Red Ginseng Extract through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health

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