Study of the electrochemical properties of Pd(II) and Pt(II) complexes containing ferrocenyl ligands and their interaction with DNA

Complexes of dichloro[2-(dimethylaminomethyl)phenyl-C1,N]gold(III), [Au(damp-C1,N)Cl2], with formylferrocene thiosemicarbazones: synthesis, structure and cytotoxicity

“…The shift towards more positive values suggests that the inductive effect of gold, when bound to the TSC chain, is transferred to the iron atom, thus reducing the proclivity of Fe(II) to oxidize. A similar situation was observed previously when other ferrocene derivatives were metallated [19]. This change in the redox behaviour of the ferrocenyl group could be relevant for the in vivo effects of these compounds.…”

Pd(II) and Pt(II) complexes with aromatic diamines: study of their interaction with DNA

“…This sort of transformation indicates the beginning of B ! C forms transformation with increasing winding of the DNA helix by rotation of the bases [30][31][32][33][34][35]. The destabilization of the B form may be produced by a bifunctional covalent DNA interaction with the complexes similar to that of cisplatin.…”

The importance of the length of the –(CH2)n– chain on the cycloplatination of the [(η5-C5H5)Fe{(η5-C5H4)–CHN–(CH2)n–NMe2}] (n=2 or 3) ligands and the properties of the platinacycles

“…For 2b and 4b, the waves were shifted to the more cathodic region than for the free ligand, 1b [7] and the magnitude of the shift was greater for 2b than for 4b 1 Preparation and characterisation data for 2b. cis-[PtCl 2 (dmso) 2 ] (0.225 g, 5.3 · 10 À4 mol) and 1b (0.151 g, 5.3 · 10 À4 mol) were suspended in toluene (20 mL).…”

“…Besides that, the differences observed in the electrochemical data for 2a and 2b (Table 1) do not clearly exceed 3r, thus, suggesting that the length of the -(CH 2 ) n -backbone does not affect significantly the electrochemical behaviour of the two platinacycles. Table 1 Summary of electrochemical data: anodic and cathodic potentials (E pa and E pc , respectively) [referred to the ferrocene/ferricinium couple] together with the separation between peaks (DE) (in mV) for: 1b, [7]. b This work.…”