Study of the first antibacterial agent pipemidic acid modifying Keggin polyoxometalate

Metal Complexes of Quinolone Antibiotics and Their Applications: An Update

“…Starting to polyoxometalates (POMs) and the quinolone antibacterial drug pipemidic acid (HPPA), complexes as {[Co(PPA) 2 ]H 2 [SiW 12 O 40 ]}∙HPP∙3H 2 O [113], [Cu(PPA) 2 ] 2 ·[PW 12 O 40 ]∙6H 2 O [114], {[Ni(PPA) 2 ]H 4 [SiW 12 O 40 ]}∙HPPA∙3H2O, and {[Zn(PPA) 2 ] 2 H 4 [SiW 12 O 40 ]}∙3H 2 O [115] were obtained. By introducing different quinolone antibacterial drugs into the octamolybdate POMs new compounds have been isolated, such as [Cu II (L 1 ) 2 (H 2 O) 2 ]H 2 [β-Mo 8 O 26 ]∙4H 2 O (1), [Cu II 2 (L 2 ) 4 ][δ-Mo 8 O 26 ]∙4H 2 O (2), [Cu II 2 (L 3 ) 2 (H 2 O) 2 ][β-Mo 8 O 26 ] (3), [Cu II 2 (L 4 ) 2 (H 2 O) 4 ][β-Mo 8 O 26 ]∙2H 2 O (4) (where L 1 = enrofloxacin; L 2 = pipemidic acid; L 3 = norfloxacin; L 4 = enoxacin) [111].…”

“…The inhibitory effect against MCF-7 cells lines showed that the complex and pipemidic acid have shown high antitumor activity to MCF-7, whereas the parent compound SiW 12 exhibits no antitumor activity to MCF-7. Furthermore, the antitumor activity of complex was higher that that of its parent compounds, and this superiority could be explained from the synergism of POMs and Co-PPA [113]. Other complexes of pipemidic acid, [Cu(PPA) 2 ] 2 ∙[PW 12 O 40 ]∙6H 2 O), [HPPA] 5 ∙[PW 11 CdO 39 ]∙2H 2 O, and [HPPA] 3 ∙[PW 12 O 40 ]∙2H 2 O showed a stronger antitumor activity than that of the parent anion against PC-3, Hela and HepG2 cells [114].…”

Towards anticancer fluoroquinolones: A review article

“…Formulation of polyoxometalates constituting a growing class of metal ion complexes in chemistry can serve as a valuable approach for designing effective anticancer agents . Enrofloxacin, norfloxacin, enoxacin, and pipemidic acid as complexes with copper and octamolybdates (Figure ) were tested for the antitumor activity using a human gastric cancer cell line, SGC‐7901.…”

Preparation of a cobalt mono-substituted silicotungstic acid doped with aniline for the selective adsorption of ovalbumin

“…1,2,7 The unique surface charge distribution, diverse compositional/ structural varieties and favorable stability of POMs have been demonstrated in the fields of catalysis, medicine, materials science, surface chemistry, biology, photochromism and electrochromism. [8][9][10][11][12][13] In particular, POMs exhibit well-documented biological activities, and thus have found promising applications as anti-tumor, -viral and -bacterial inorganic medicinal agents. [14][15][16] The antibacterial activity of POMs could be controlled by regulating their structures or morphologies.…”

“…[14][15][16] The antibacterial activity of POMs could be controlled by regulating their structures or morphologies. 11,17 Nanocomposites based on Keggin-type polyoxometalates and porous bamboo charcoal can exhibit excellent antibacterial performance. 18 The application of polyoxometalate-based materials in biological fields is mostly based on their following features, e.g., polarity, morphology, acidity, redox properties, and electron donating and accepting capability, which can be easily modulated.…”