Study Of The General Pharmacological Properties Of A New Antiarrhythmic N-Deacetyllappaconitine With Oral Administration

Abstract

The aim of the present study was to study a new antiarrhythmic effect of N-deacetyllappaconitine on the general pharmacological irritant effect on the skin, when applied to the conjunctival sac of the eye, mucosal hyperemia and lacrimation, cumulative, allergenic and diuretic effects. At the same time, it does not cause changes, which makes it more secure.

Evaluation of Anticonvulsant Activity of Allapinine and N-Deacetylappaconitine in Experimental Animals.

“…Jahangirov, J. Rejepov, etc., conducted large-scale studies on the individual isolation of the substance N-Deacetylappaconitine and the study of its pharmacotoxicological properties and achieved scientific and practical success. Conducted preclinical experiments have shown that N-DAL in its individual form is low-toxic, several times superior in the breadth of therapeutic action, antiarrhythmic index compared to allapinin [15][16][17][18][19][20][21]. Despite the long-term use of allapinin in clinical practice and N-Deacetylappaconitin in preclinical research, information about the results of its study to date is few and often contradictory.…”