The first synthesized derivative of (3¢,4¢-methylenedioxyphenyl)-6,7-methylenedioxy-1,2,3,4tetrahydroquinoline, conventionally designated F-29, showed neuroleptic properties-they have hypothermic, cataleptogenic, less pronounced suppression of motor activity, lack of central αadreno-and M-anticholinergic action and less toxic in severity comparable to the activity of a more close analogue of the neuroleptic haloperidol, which has motor and autonomic disorders [1], which F-29 lacks.

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In chronic experiments in laboratory animals, studied toxicological perspective new antiarrhythmic effect of N-deacetyllappaconitine for the treatment of arrhythmic states, an original herbal preparation based on Aconitum leucostonum, Ac.Septentrionale was created. During 2,5 months of intragastric administration in animals exposed to all doses of N-deacetyllappaconitine, no deviations in the parameters of the functioning of the nervous system were found, therefore, this value is the lowest effective (threshold) dose in a chronic experiment.

The aim of the present study was to study a new antiarrhythmic effect of N-deacetyllappaconitine on the general pharmacological irritant effect on the skin, when applied to the conjunctival sac of the eye, mucosal hyperemia and lacrimation, cumulative, allergenic and diuretic effects. At the same time, it does not cause changes, which makes it more secure.

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