Pharmacological Activity Of The Possessing New Atypical Neuroleptics 1-Phenyltetrahydroisoquinoline Structure

Abstract

The first synthesized derivative of (3¢,4¢-methylenedioxyphenyl)-6,7-methylenedioxy-1,2,3,4tetrahydroquinoline, conventionally designated F-29, showed neuroleptic properties-they have hypothermic, cataleptogenic, less pronounced suppression of motor activity, lack of central αadreno-and M-anticholinergic action and less toxic in severity comparable to the activity of a more close analogue of the neuroleptic haloperidol, which has motor and autonomic disorders [1], which F-29 lacks.

Experimental Study of the Psychopharmacological Activity of 1-Aryl-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline

“…Юнусова [7]. Ushbu sintez qilingan birikmalar orasidan atipik neyroleptik [8,9], sedativ anksiolitik [10,11] faollikka эga bo'lgan moddalar aniqlandi. Shu maqsadda 1-aril-6,7dimetoksi-1,2,3,4-tetragidroizoxinolin alkaloidi sintezlanib, psixofarmakologik izlanishlar olib borildi.…”

Efficiency of Disinfection of Dental Instruments and Products Contaminated With Various Microorganisms

“…Subsequently, the introduction of more effective and less toxic drugs into medical practice led to the fact that phenothiazine remained in the arsenal of veterinary medicine (for the treatment of helminthic infestations) and disinfection services (a remedy for the destruction of mosquito larvae) [9]. And also in the study of new psychotropic and neuroleptic drugs, atypical antipsychotic [10,11,12], psychotropic properties [13,14,15] were studied and the study of antiseptic and disinfectant action was provided.…”

Study of Acute Toxicity and Psychopharmacological Activity of 1-(2-Hydroxyphenyl)-6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline

“…Шу сабабли Ўсимлик моддалари кимёси институти алкалоидлар кимёси лабораториясида изохинолин алкалоидлари асосида янги бирикмаларнинг синтези амалга оширилмоқда [6]. Ушбу синтез қилинган бирикмалар орасидан атипик нейролептик [7,8], седатив анксиолитик [9,10] тажрибаларда [12] 1 мг/кг дан то 100 мг/кг дозагача оғиз орқали юборилганда ўткир заҳарлилиги, ҳаракатланиш активлиги, этаминал-натрий 40 мг/кг дозада қорин бўшлиғига юбориш ёрдамида чақирилган уйқу давомийлигига ва Sanberg [13] усули ёрдамида ахлат ажратишлар сонига таъсири, стрихнин, коразол таъсирида чақирилган тутқаноққа таъсири, галоперидолдан юзага келадиган каталепсия довомийлигини ҳамда Porsolt [14] усули бўйича мажбурий сузиш давомийлигига таъсири ўрганиб чиқилди. Ўрганилувчи модда ва референс препаратлар анализаторлардан 60 дақиқа олдин юборилди.…”