Study of the Human Auditory Cortices Using a Whole-Head Magnetometer: Left vs. Right Hemisphere and Ipsilateral vs. Contralateral Stimulation

Pantev, Christo; Roß, Bernhard; Berg, Patrick; Elbert, Thomas; Rockstroh, Brigitte

doi:10.1159/000013789

Cited by 99 publications

(85 citation statements)

References 27 publications

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“…For example, right hemisphere N1m generators are of greater amplitude (Kanno et al, 1996) and cover a larger area (Zouridakis et al, 1998) in the auditory cortex than do left hemisphere N1m generators. In the present study, N1m source location was more anterior in the right than in the left hemisphere, which is in agreement with previous whole-head MEG studies (Mäkelä et al, 1993;Nakasato et al, 1995;Pantev et al, 1998). This observation can be explained by the fact that the left temporal plane of right-handed subjects is significantly more posterior than the right (Geschwind and Levitsky, 1968;Szikla et al, 1977).…”

Section: Differences Between Hemispheressupporting

confidence: 93%

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

et al. 2004

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The aim of the present study was to investigate the functional organization of the auditory cortex for pure tones of 1, 2, 4, 6, 8 and 12 kHz. Ten subjects were tested with a whole-head magnetometer (151 channels). The location, latency and amplitude of the generators of the N1m (the main component of the response, peaking approximately at 100 ms) were explored simultaneously in the right and left hemispheres under monaural stimulation. Our results revealed that tonotopy is a rather complex functional organization of the auditory cortex. From 1 to 12 kHz, tonotopic maps were found for contralateral as well as for ipsilateral stimulation: N1m generators were found to be tonotopically organized mainly in an anterior-posterior direction in both hemispheres, whatever the stimulated ear, but also in an inferior-superior direction in the right hemisphere. Furthermore, latencies were longer in the left than in the right hemisphere. Two different representations of spectral distribution were found in the right auditory cortex: one for ipsilateral and one for contralateral stimulation.

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Section: Differences Between Hemispheressupporting

confidence: 93%

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

et al. 2004

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“…Previous MEG and EEG studies have revealed that activation in the auditory cortices of both hemispheres is stronger for contralateral auditory stimulation [11,[32][33][34][35]37,51,52]. These findings are further corroborated by results obtained in animal models [14,18].…”

Section: Introductionsupporting

confidence: 69%

“…There is fairly good agreement that both hemispheres respond more vigorously to contralaterally presented auditory stimuli as shown by studies using monaural [34,35,37,51,52] and spatial stimulation using 3D audio [11,32,33]. However, for stimuli presented laterally via ITD, some studies have reported contralaterally larger responses [28], while others have found no significant differences between contra-and ipsilateral stimulation [51].…”

Section: Discussionmentioning

confidence: 60%

“…Similarly, for the ITD stimuli ( F[7,63] = 3.71, P b 0.01), post hoc analyses revealed that the ECDs for the 08 angle (À1.0 mm) were posterior to those of the 908 (4.1 mm), À908 (5.2 mm), and À458 (3.8 mm) direction angles ( P b 0.05 for all comparisons). In the left hemisphere, direction angle had a significant effect only on the ECD x-coordinate for the HRTF stimuli ( F [7,35] = 3.77, P b 0.01). Post hoc analyses revealed that the ECDs for the À1358 direction angle (À57.5 mm) were lateral to those of the 908 (À52.2 mm), 1358 (À52.4 mm), 1808 (À52.0 mm), and À458 (À55.1 mm) angles ( P b 0.05 for all comparisons).…”

Section: The N1m Source Location Analysismentioning

confidence: 95%

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Spatial processing in human auditory cortex: The effects of 3D, ITD, and ILD stimulation techniques

Palomäki

Tiitinen

Mäkinen

et al. 2005

Cognitive Brain Research

100

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Here, the perception of auditory spatial information as indexed by behavioral measures is linked to brain dynamics as reflected by the N1m response recorded with whole-head magnetoencephalography (MEG). Broadband noise stimuli with realistic spatial cues corresponding to eight direction angles in the horizontal plane were constructed via custom-made, individualized binaural recordings (BAR) and generic head-related transfer functions (HRTF). For comparison purposes, stimuli with impoverished acoustical cues were created via interaural time and level differences (ITDs and ILDs) and their combinations. MEG recordings in ten subjects revealed that the amplitude and the latency of the N1m exhibits directional tuning to sound location, with the amplitude of the right-hemispheric N1m being particularly sensitive to the amount of spatial cues in the stimuli. The BAR, HRTF, and combined ITD + ILD stimuli resulted both in a larger dynamic range and in a more systematic distribution of the N1m amplitude across stimulus angle than did the ITD or ILD stimuli alone. Further, the righthemispheric source loci of the N1m responses for the BAR and HRTF stimuli were anterior to those for the ITD and ILD stimuli. In behavioral tests, we measured the ability of the subjects to localize BAR and HRTF stimuli in terms of azimuthal error and front-back confusions. We found that behavioral performance correlated positively with the amplitude of the N1m. Thus, the activity taking place already in the auditory cortex predicts behavioral sound detection of spatial stimuli, and the amount of spatial cues embedded in the signal are reflected in the activity of this brain area. D

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“…Others undertaken more recently (typically utilizing fMRI) have demonstrated that the cortex is arranged into two mirror-symmetric gradients extending in an anterior-posterior orientation (Humphries et al, 2010). Our previous studies using MEG and those of other groups report the former finding that, at least for M100, the responses are arranged from high to low tones, medially to laterally or posteriorly to anteriorly along Heschl's gyrus (Pantev et al, 1988;Pantev et al, 1998;Huotilainen, 1995;Arlinger et al, 1982;Rosburg et al, 2000). Importantly, the methodological differences between these studies on tonotopy may explain the variability between studies.…”

Section: Discussionmentioning

confidence: 93%

Lack of tonotopic organization of the auditory cortex in schizophrenia

Ragole

Slason

Teale

et al. 2014

Preprint

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Background: Disorganization of tonotopy in the auditory cortex has been described in schizophrenia. Subjects with schizophrenia show little to no spatial organization of responses to different tone frequencies in the auditory cortex. Previous studies have called into question the use of MEG and the M100 response to assess tonotopy. This study seeks to replicate prior results of tonotopic disorganization in schizophrenia compared to healthy controls.

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Study of the Human Auditory Cortices Using a Whole-Head Magnetometer: Left vs. Right Hemisphere and Ipsilateral vs. Contralateral Stimulation

Cited by 99 publications

References 27 publications

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

Effect of stimulus frequency and stimulation site on the N1m response of the human auditory cortex

Spatial processing in human auditory cortex: The effects of 3D, ITD, and ILD stimulation techniques

Lack of tonotopic organization of the auditory cortex in schizophrenia

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